Literature DB >> 30869656

Double-headed nanosystems for oral drug delivery.

G Kaur1, M Arora, R Ganugula, M N V Ravi Kumar.   

Abstract

We demonstrate a novel strategy to engineer double-headed nanosystems by chemical modification of the carboxyl terminal polyester with a linker that offers tripodal arrangement of ligands on the particle surfaces. The in vivo results suggest that the bioavailability of encapsulated curcumin is proportional to the ligand density rendered by double-headed nanosystems.

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Year:  2019        PMID： 30869656      PMCID： PMC6472980          DOI： 10.1039/c8cc10021g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  33 in total

Review 1.  The potential use of receptor-mediated endocytosis for oral drug delivery.

Authors:  G J Russell-Jones
Journal:  Adv Drug Deliv Rev       Date:  2001-03-01       Impact factor: 15.470

2.  Tripodal transmembrane transporters for bicarbonate.

Authors:  Nathalie Busschaert; Philip A Gale; Cally J E Haynes; Mark E Light; Stephen J Moore; Christine C Tong; Jeffery T Davis; William A Harrell
Journal:  Chem Commun (Camb)       Date:  2010-08-06       Impact factor: 6.222

3.  Tripodal, cooperative, and allosteric transphosphorylation metallocatalysts.

Authors:  Alessandro Scarso; Giovanni Zaupa; Florence Bodar Houillon; Leonard J Prins; Paolo Scrimin
Journal:  J Org Chem       Date:  2007-01-19       Impact factor: 4.354

4.  Materials science: supramolecular polymers.

Authors:  Tom F A de Greef; E W Meijer
Journal:  Nature       Date:  2008-05-08       Impact factor: 49.962

5.  Molecular understanding and modern application of traditional medicines: triumphs and trials.

Authors:  Timothy W Corson; Craig M Crews
Journal:  Cell       Date:  2007-09-07       Impact factor: 41.582

Review 6.  Functional supramolecular polymers.

Authors:  T Aida; E W Meijer; S I Stupp
Journal:  Science       Date:  2012-02-17       Impact factor: 47.728

7.  Absolute configuration of (-)-gambogic acid, an antitumor agent.

Authors:  Yulin Ren; Chunhua Yuan; Hee-byung Chai; Yuanqing Ding; Xing-Cong Li; Daneel Ferreira; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2010-11-10       Impact factor: 4.050

8.  Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers.

Authors:  Frank Gu; Liangfang Zhang; Benjamin A Teply; Nina Mann; Andrew Wang; Aleksandar F Radovic-Moreno; Robert Langer; Omid C Farokhzad
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-13       Impact factor: 11.205

9.  TREN (Tris(2-aminoethyl)amine): an effective scaffold for the assembly of triple helical collagen mimetic structures.

Authors:  Juliann Kwak; Antonia De Capua; Elsa Locardi; Murray Goodman
Journal:  J Am Chem Soc       Date:  2002-11-27       Impact factor: 15.419

10.  Multivalent scaffolds for affinity maturation of small molecule cell surface binders and their application to prostate tumor targeting.

Authors:  Valerie Humblet; Preeti Misra; Kumar R Bhushan; Khaled Nasr; Yao-Sen Ko; Takashi Tsukamoto; Nadine Pannier; John V Frangioni; Wolfgang Maison
Journal:  J Med Chem       Date:  2009-01-22       Impact factor: 7.446
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  4 in total

1.  Oral Drug Delivery Technologies-A Decade of Developments.

Authors:  G Kaur; M Arora; M N V Ravi Kumar
Journal:  J Pharmacol Exp Ther       Date:  2019-04-22       Impact factor: 4.030

2.  Next-Generation Noncompetitive Nanosystems Based on Gambogic Acid: In silico Identification of Transferrin Receptor Binding Sites, Regulatory Shelf Stability, and Their Preliminary Safety in Healthy Rodents.

Authors:  M Arora; R Ganugula; N Kumar; G Kaur; J-P Pellois; P Garg; M N V Ravi Kumar
Journal:  ACS Appl Bio Mater       Date:  2019-07-04

3.  Nanoparticles that do not compete with endogenous ligands - Molecular characterization in vitro, acute safety in canine, and interspecies pharmacokinetics modeling to humans.

Authors:  Dianxiong Zou; Meenakshi Arora; Raghu Ganugula; Mokshada Kumar; Erin M Scott; Dhaval Shah; M N V Ravi Kumar
Journal:  J Control Release       Date:  2021-02-16       Impact factor: 9.776

4.  Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation.

Authors:  R Ganugula; M Arora; M A Lepiz; Y Niu; B K Mallick; S C Pflugfelder; E M Scott; M N V Ravi Kumar
Journal:  Sci Adv       Date:  2020-08-26       Impact factor: 14.136
  4 in total

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