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Literature DB >> 25857211

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution.

Charles N Serhan¹, Nan Chiang², Jesmond Dalli².

Abstract

Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro-resolving mediators (SPM) including lipoxins, resolvins, protectins and maresins that are each temporally produced by resolving-exudates with distinct actions for return to homeostasis. SPM evoke potent anti-inflammatory and novel pro-resolving mechanisms as well as enhance microbial clearance. While born in inflammation-resolution, SPM are conserved structures with functions discovered in microbial defense, pain, organ protection and tissue regeneration, wound healing, cancer, reproduction, and neurobiology-cognition. This review covers these SPM mechanisms and other new omega-3 PUFA pathways that open their path for functions in resolution physiology.

Entities: CellLine Chemical Disease Gene Species

Keywords: Essential fatty acids; Host defense; Infection; Inflammation; Lipid mediator

Mesh：

Substances：

Year: 2015 PMID： 25857211 PMCID： PMC4515371 DOI： 10.1016/j.smim.2015.03.004

Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130

197 in total

1. Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production.

Authors: Marion Man-Ying Chan; Andrea Rossi Moore
Journal: J Immunol Date: 2010-04-30 Impact factor: 5.422

2. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception.

Authors: S Bang; S Yoo; T J Yang; H Cho; Y G Kim; S W Hwang
Journal: Br J Pharmacol Date: 2010-10 Impact factor: 8.739

3. Regulatory expression of lipoxin A4 receptor in physiologically estrus cycle and pathologically endometriosis.

Authors: E Motohashi; H Kawauchi; H Endo; H Kondo; H Kitasato; H Kuramoto; M Majima; N Unno; I Hayashi
Journal: Biomed Pharmacother Date: 2005-07 Impact factor: 6.529

Review 4. The isoprostanes: unique bioactive products of lipid peroxidation.

Authors: J D Morrow; L J Roberts
Journal: Prog Lipid Res Date: 1997-03 Impact factor: 16.195

5. Neuroprotective effect of lipoxin A4 methyl ester in a rat model of permanent focal cerebral ischemia.

Authors: Yan Wu; Xi-Hong Ye; Pei-Pei Guo; San-Peng Xu; Jie Wang; Shi-Ying Yuan; Shang-Long Yao; You Shang
Journal: J Mol Neurosci Date: 2010-04-17 Impact factor: 3.444

6. Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice.

Authors: Tomohiro Yamada; Yukako Tani; Hiroki Nakanishi; Ryo Taguchi; Makoto Arita; Hiroyuki Arai
Journal: FASEB J Date: 2010-10-19 Impact factor: 5.191

7. Tonic inhibition of chemotaxis in human plasma.

Authors: Stephen E Malawista; Anne de Boisfleury Chevance; Jo van Damme; Charles N Serhan
Journal: Proc Natl Acad Sci U S A Date: 2008-11-07 Impact factor: 11.205

8. Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1.

Authors: Gabrielle Fredman; Sungwhan F Oh; Srinivas Ayilavarapu; Hatice Hasturk; Charles N Serhan; Thomas E Van Dyke
Journal: PLoS One Date: 2011-09-14 Impact factor: 3.240

Review 9. Role of basic science in the development of new medicines: examples from the eicosanoid field.

Authors: Bengt Samuelsson
Journal: J Biol Chem Date: 2012-02-08 Impact factor: 5.157

10. Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor.

Authors: Fabricio A Pamplona; Juliano Ferreira; Octávio Menezes de Lima; Filipe Silveira Duarte; Allisson Freire Bento; Stefânia Forner; Jardel G Villarinho; Luigi Bellocchio; Luigi Bellochio; Carsten T Wotjak; Raissa Lerner; Krisztina Monory; Beat Lutz; Claudio Canetti; Isabelle Matias; João Batista Calixto; Giovanni Marsicano; Marilia Z P Guimarães; Reinaldo N Takahashi
Journal: Proc Natl Acad Sci U S A Date: 2012-11-12 Impact factor: 11.205

202 in total

1. Resolvin D1, resolvin D2 and maresin 1 activate the GSK3β anti-inflammatory axis in TLR4-engaged human monocytes.

Authors: Zhen Gu; Gwyneth J Lamont; Richard J Lamont; Silvia M Uriarte; Huizhi Wang; David A Scott
Journal: Innate Immun Date: 2016-02-15 Impact factor: 2.680

Review 2. Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction.

Authors: Alan J Mouton; Osvaldo J Rivera Gonzalez; Amanda R Kaminski; Edwin T Moore; Merry L Lindsey
Journal: Pharmacol Res Date: 2018-10-28 Impact factor: 7.658

Review 3. Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms.

Authors: Charles N Serhan
Journal: FASEB J Date: 2017-01-13 Impact factor: 5.191

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution.

1. Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production.

2. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception.

3. Regulatory expression of lipoxin A4 receptor in physiologically estrus cycle and pathologically endometriosis.

Review 4. The isoprostanes: unique bioactive products of lipid peroxidation.

5. Neuroprotective effect of lipoxin A4 methyl ester in a rat model of permanent focal cerebral ischemia.

6. Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice.

7. Tonic inhibition of chemotaxis in human plasma.

8. Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1.

Review 9. Role of basic science in the development of new medicines: examples from the eicosanoid field.

10. Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor.

1. Resolvin D1, resolvin D2 and maresin 1 activate the GSK3β anti-inflammatory axis in TLR4-engaged human monocytes.

Review 2. Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction.

Review 3. Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms.

Review 4. Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation.

Review 5. Mechanisms and Therapeutic Relevance of Neuro-immune Communication.

Review 6. Advances in Biomaterials for Drug Delivery.

Review 7. Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain.

Review 8. Bioactive lipids and pathological retinal angiogenesis.

Review 9. Can Specialized Pro-resolving Mediators Deliver Benefit Originally Expected from Fish Oil?

Review 10. Carbon monoxide in the treatment of sepsis.