| Literature DB >> 29712059 |
Lee Josephson1, J Manuel Perez1, Ralph Weissleder1.
Abstract
Superparamagnetic nanoparticles conjugated to oligonucleotides exert sensitive and reversible effects on the spin-spin relaxation rates of adjacent water protons when the conjugates hybridize to target oligonucleotides (see temperature cycle in the picture). The fluid-phase magnetic sensors provide the basis for detecting specific nucleic acid sequences in turbid media and potentially in tissues in vivo.Entities:
Keywords: DNA recognition; magnetic properties; nanostructures; oligonucleotides
Year: 2001 PMID: 29712059 DOI: 10.1002/1521-3773(20010903)40:17<3204::AID-ANIE3204>3.0.CO;2-H
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN: 1433-7851 Impact factor: 15.336