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Literature DB >> 20338204

Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates.

Jung Heon Lee¹, Mehmet V Yigit, Debapriya Mazumdar, Yi Lu.

Abstract

Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents. Copyright 2010 Elsevier B.V. All rights reserved.

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Year: 2010 PMID： 20338204 PMCID： PMC2924639 DOI： 10.1016/j.addr.2010.03.003

Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470

160 in total

1. Shape control of CdSe nanocrystals

Authors:
Journal: Nature Date: 2000-03-02 Impact factor: 49.962

2. Detection of single-base DNA mutations by enzyme-amplified electronic transduction.

Authors: F Patolsky; A Lichtenstein; I Willner
Journal: Nat Biotechnol Date: 2001-03 Impact factor: 54.908

3. Adenine-aptamer complexes: a bipartite RNA site that binds the adenine nucleic base.

Authors: Marc Meli; Jacques Vergne; Jean-Luc Décout; Marie-Christine Maurel
Journal: J Biol Chem Date: 2001-11-08 Impact factor: 5.157

4. Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization.

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Journal: Chem Rev Date: 1999-07-14 Impact factor: 60.622

6. Systematic evolution of a DNA aptamer binding to rat brain tumor microvessels. selective targeting of endothelial regulatory protein pigpen.

Authors: M Blank; T Weinschenk; M Priemer; H Schluesener
Journal: J Biol Chem Date: 2001-02-13 Impact factor: 5.157

7. Magnetic relaxation switches capable of sensing molecular interactions.

Authors: J Manuel Perez; Lee Josephson; Terrence O'Loughlin; Dagmar Högemann; Ralph Weissleder
Journal: Nat Biotechnol Date: 2002-07-22 Impact factor: 54.908

8. Aptamer-based colorimetric probe for cocaine.

Authors: Milan N Stojanovic; Donald W Landry
Journal: J Am Chem Soc Date: 2002-08-21 Impact factor: 15.419

9. In vitro selection of DNA aptamers to anthrax spores with electrochemiluminescence detection.

Authors: J G Bruno; J L Kiel
Journal: Biosens Bioelectron Date: 1999-05-31 Impact factor: 10.618

10. Antiproliferative activity of G-rich oligonucleotides correlates with protein binding.

Authors: P J Bates; J B Kahlon; S D Thomas; J O Trent; D M Miller
Journal: J Biol Chem Date: 1999-09-10 Impact factor: 5.157

57 in total

Review 1. Responsive theranostic systems: integration of diagnostic imaging agents and responsive controlled release drug delivery carriers.

Authors: Mary E Caldorera-Moore; William B Liechty; Nicholas A Peppas
Journal: Acc Chem Res Date: 2011-09-20 Impact factor: 22.384

Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates.

1. Shape control of CdSe nanocrystals

2. Detection of single-base DNA mutations by enzyme-amplified electronic transduction.

3. Adenine-aptamer complexes: a bipartite RNA site that binds the adenine nucleic base.

4. Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization.

5. Nanotubes from Carbon.

6. Systematic evolution of a DNA aptamer binding to rat brain tumor microvessels. selective targeting of endothelial regulatory protein pigpen.

7. Magnetic relaxation switches capable of sensing molecular interactions.

8. Aptamer-based colorimetric probe for cocaine.

9. In vitro selection of DNA aptamers to anthrax spores with electrochemiluminescence detection.

10. Antiproliferative activity of G-rich oligonucleotides correlates with protein binding.

Review 1. Responsive theranostic systems: integration of diagnostic imaging agents and responsive controlled release drug delivery carriers.

2. Direct optical detection of viral nucleoprotein binding to an anti-influenza aptamer.

3. Cell targeting with hybrid Qβ virus-like particles displaying epidermal growth factor.

Review 4. Aptamer-based fluorescent biosensors.

Review 5. Tumor-targeted drug delivery with aptamers.

Review 6. Molecular imaging with nucleic acid aptamers.

7. Can nanotechnology potentiate photodynamic therapy?

8. Transfer of molecular recognition information from DNA nanostructures to gold nanoparticles.

9. A Broadly Applicable Assay for Rapidly and Accurately Quantifying DNA Surface Coverage on Diverse Particles.

Review 10. Functional DNA nanomaterials for sensing and imaging in living cells.