| Literature DB >> 29709168 |
Ryan F Landis1, Cheng-Hsuan Li1, Akash Gupta1, Yi-Wei Lee1, Mahdieh Yazdani1, Nipaporn Ngernyuang1,2, Ismail Altinbasak3, Sanaa Mansoor1, Muhammadaha A S Khichi1, Amitav Sanyal3, Vincent M Rotello1.
Abstract
Infections caused by multidrug-resistant (MDR) bacteria are a rapidly growing threat to human health, in many cases exacerbated by their presence in biofilms. We report here a biocompatible oil-in-water cross-linked polymeric nanocomposite that degrades in the presence of physiologically relevant biomolecules. These degradable nanocomposites demonstrated broad-spectrum penetration and elimination of MDR bacteria, eliminating biofilms with no toxicity to cocultured mammalian fibroblast cells. Notably, serial passaging revealed that bacteria were unable to develop resistance toward these nanocomposites, highlighting the therapeutic promise of this platform.Entities:
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Year: 2018 PMID： 29709168 PMCID： PMC6044909 DOI： 10.1021/jacs.8b03575
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419