| Literature DB >> 32814862 |
Jessa Marie V Makabenta1, Ahmed Nabawy1, Cheng-Hsuan Li1, Suzannah Schmidt-Malan2, Robin Patel2, Vincent M Rotello3.
Abstract
Antibiotic-resistant bacterial infections arising from acquired resistance and/or through biofilm formation necessitate the development of innovative 'outside of the box' therapeutics. Nanomaterial-based therapies are promising tools to combat bacterial infections that are difficult to treat, featuring the capacity to evade existing mechanisms associated with acquired drug resistance. In addition, the unique size and physical properties of nanomaterials give them the capability to target biofilms, overcoming recalcitrant infections. In this Review, we highlight the general mechanisms by which nanomaterials can be used to target bacterial infections associated with acquired antibiotic resistance and biofilms. We emphasize design elements and properties of nanomaterials that can be engineered to enhance potency. Lastly, we present recent progress and remaining challenges for widespread clinical implementation of nanomaterials as antimicrobial therapeutics.Entities:
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Year: 2020 PMID： 32814862 PMCID： PMC8559572 DOI： 10.1038/s41579-020-0420-1
Source DB: PubMed Journal: Nat Rev Microbiol ISSN： 1740-1526 Impact factor: 60.633