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Literature DB >> 34416106

Biodegradable Poly(lactic acid) Stabilized Nanoemulsions for the Treatment of Multidrug-Resistant Bacterial Biofilms.

Yavuz Oz^1,2, Ahmed Nabawy², Stefano Fedeli², Aarohi Gupta², Rui Huang², Amitav Sanyal^1,3, Vincent M Rotello².

Abstract

Biofilm infections caused by multidrug-resistant (MDR) bacteria are an urgent global health threat. Incorporation of natural essential oils into biodegradable oil-in-water cross-linked polymeric nanoemulsions (X-NEs) provides effective eradication of MDR bacterial biofilms. The X-NE platform combines the degradability of functionalized poly(lactic acid) polymers with the antimicrobial activity of carvacrol (from oregano oil). These X-NEs exhibited effective penetration and killing of biofilms formed by pathogenic bacteria. Biofilm-fibroblast coculture models demonstrate that X-NEs selectively eliminate bacteria without harming mammalian cells, making them promising candidates for antibiofilm therapeutics.

Entities: Chemical

Keywords: antimicrobials; biodegradable polymers; biofilm infections; multidrug resistance; nanoemulsions

Mesh：

Substances：

Year: 2021 PMID： 34416106 PMCID： PMC8573728 DOI： 10.1021/acsami.1c11265

Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 10.383

43 in total

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2. Self-Assembled Cationic Nanoparticles Combined with Curcumin against Multidrug-Resistant Bacteria.

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