Sally Chiu1,2, Kathleen Mulligan1,3,4, Jean-Marc Schwarz1,3,4. 1. College of Osteopathic Medicine, Touro University California, Vallejo. 2. Children's Hospital Oakland Research Institute, Oakland. 3. Department of Medicine, University of California, San Francisco. 4. Division of Endocrinology, Zuckerberg San Francisco General Hospital, San Francisco, California, USA.
Abstract
PURPOSE OF REVIEW: To review recent evidence for the role of dietary carbohydrate in de novo lipogenesis (DNL) and nonalcoholic fatty liver disease (NAFLD). RECENT FINDINGS: A large body of evidence suggests that increased hepatic DNL is a significant pathway contributing to the development of NAFLD. Dietary carbohydrates, in particular, fructose, have been shown to stimulate DNL and increase liver fat, although it is debated whether this is due to excess energy or fructose per se. Recent dietary intervention studies conducted in energy balance show that high-fructose diets increase DNL and liver fat, whereas fructose restriction decreases DNL and liver fat. SUMMARY: The association of high-carbohydrate and high-sugar diets with NAFLD may in part be explained by the effect of sugar on increasing hepatic DNL.
PURPOSE OF REVIEW: To review recent evidence for the role of dietary carbohydrate in de novo lipogenesis (DNL) and nonalcoholic fatty liver disease (NAFLD). RECENT FINDINGS: A large body of evidence suggests that increased hepatic DNL is a significant pathway contributing to the development of NAFLD. Dietary carbohydrates, in particular, fructose, have been shown to stimulate DNL and increase liver fat, although it is debated whether this is due to excess energy or fructose per se. Recent dietary intervention studies conducted in energy balance show that high-fructose diets increase DNL and liver fat, whereas fructose restriction decreases DNL and liver fat. SUMMARY: The association of high-carbohydrate and high-sugar diets with NAFLD may in part be explained by the effect of sugar on increasing hepatic DNL.
Authors: Catherine C Cohen; Kelvin W Li; Adina L Alazraki; Carine Beysen; Carissa A Carrier; Rebecca L Cleeton; Mohamad Dandan; Janet Figueroa; Jack Knight-Scott; Cynthia J Knott; Kimberly P Newton; Edna M Nyangau; Claude B Sirlin; Patricia A Ugalde-Nicalo; Jean A Welsh; Marc K Hellerstein; Jeffrey B Schwimmer; Miriam B Vos Journal: J Clin Invest Date: 2021-12-15 Impact factor: 19.456
Authors: Jeffrey B Schwimmer; Patricia Ugalde-Nicalo; Jean A Welsh; Jorge E Angeles; Maria Cordero; Kathryn E Harlow; Adina Alazraki; Janis Durelle; Jack Knight-Scott; Kimberly P Newton; Rebecca Cleeton; Cynthia Knott; Juna Konomi; Michael S Middleton; Curtis Travers; Claude B Sirlin; Albert Hernandez; Ahlia Sekkarie; Courtney McCracken; Miriam B Vos Journal: JAMA Date: 2019-01-22 Impact factor: 56.272