Stijn Verwulgen1, Koen Beyers2,3, Timothi Van Mulder2,4,5, Thomas Peeters6, Steven Truijen7, Francis Dams6, Vanessa Vankerckhoven2,5. 1. Department of Product Development, Faculty of Design Sciences, University of Antwerp, Campus Mutsaard, Ambtmanstraat 1, 2000, Antwerpen, Belgium. Stijn.verwulgen@uantwerpen.be. 2. Novosanis, Wijnegem, Belgium. 3. Voxdale, Wijnegem, Belgium. 4. Department of Nursing and Midwifery, University of Antwerp, Wilrijk, Belgium. 5. Vaccine & Infectious Disease Institute, University of Antwerp, Wilrijk, Belgium. 6. Department of Product Development, Faculty of Design Sciences, University of Antwerp, Campus Mutsaard, Ambtmanstraat 1, 2000, Antwerpen, Belgium. 7. Department Rehabilitation Sciences and Physiotherapy, University of Antwerp, Wilrijk, Belgium.
Abstract
PURPOSE: The force that has to be exerted on the plunger for administering a given amount of fluid in a given time, has an important influence on comfort for the subject and usability for the administrator in intradermal drug delivery. The purpose of this study is to model those forces that are subject-independent, by linking needle and syringe geometry to the force required for ejecting a given fluid at a given ejection rate. MATERIAL AND METHODS: We extend the well-known Hagen-Poiseuille formula to predict pressure drop induced by a fluid passing through a cylindrical body. The model investigates the relation between the pressure drop in needles and the theoretic Hagen-Poiseuille prediction and is validated in fifteen needles from 26G up to 33G suited for intradermal drug delivery. We also provide a method to assess forces exerted by operators in real world conditions. RESULTS: The model is highly linear in each individual needle with R-square values ranging from 75% up to 99.9%. Ten out of fifteen needles exhibit R-square values above 99%. A proof-of-concept for force assessment is provided by logging forces in operators in real life conditions. CONCLUSIONS: The force assessment method and the model can be used to pinpoint needle geometry for intradermal injection devices, tuning comfort for subjects and usability for operators.
PURPOSE: The force that has to be exerted on the plunger for administering a given amount of fluid in a given time, has an important influence on comfort for the subject and usability for the administrator in intradermal drug delivery. The purpose of this study is to model those forces that are subject-independent, by linking needle and syringe geometry to the force required for ejecting a given fluid at a given ejection rate. MATERIAL AND METHODS: We extend the well-known Hagen-Poiseuille formula to predict pressure drop induced by a fluid passing through a cylindrical body. The model investigates the relation between the pressure drop in needles and the theoretic Hagen-Poiseuille prediction and is validated in fifteen needles from 26G up to 33G suited for intradermal drug delivery. We also provide a method to assess forces exerted by operators in real world conditions. RESULTS: The model is highly linear in each individual needle with R-square values ranging from 75% up to 99.9%. Ten out of fifteen needles exhibit R-square values above 99%. A proof-of-concept for force assessment is provided by logging forces in operators in real life conditions. CONCLUSIONS: The force assessment method and the model can be used to pinpoint needle geometry for intradermal injection devices, tuning comfort for subjects and usability for operators.
Authors: V Burckbuchler; G Mekhloufi; A Paillard Giteau; J L Grossiord; S Huille; F Agnely Journal: Eur J Pharm Biopharm Date: 2010-08-16 Impact factor: 5.571
Authors: T J S Van Mulder; M de Koeijer; H Theeten; D Willems; P Van Damme; M Demolder; G De Meyer; K C L Beyers; V Vankerckhoven Journal: Vaccine Date: 2016-08-03 Impact factor: 3.641