Raïssa Lotte1, Alexandre Lafourcade2, Pierre Mozer3, Pierre Conort3, Eric Barret4, Eva Comperat5, Malek Ezziane6, Paul-Hugo Jouve de Guibert6, Sebastian Tavolaro7, Lisa Belin2, Franck Boudghene7, Olivier Lucidarme6, Raphaële Renard-Penna8,9,10. 1. Academic Department of Radiology, Hopital Pitié-Salpétrière, AP-HP, Sorbonne University, Paris, France. raissalotte@hotmail.com. 2. Academic Department of Statistic, Hopital Pitié-Salpétrière, AP-HP, Sorbonne University, Paris, France. 3. Academic Department of Urology, Hopital Pitié-Salpétrière, AP-HP, Sorbonne University, Paris, France. 4. Urology Department, Montsouris Institute, F-75014, Paris, France. 5. Academic Department of Pathology, Hopital Pitié-Salpétrière, AP-HP, Sorbonne University, Paris, France. 6. Academic Department of Radiology, Hopital Pitié-Salpétrière, AP-HP, Sorbonne University, Paris, France. 7. Academic Department of Radiology, Hopital Tenon, AP-HP, Sorbonne University, Paris, France. 8. Academic Department of Radiology, Hopital Pitié-Salpétrière, AP-HP, Sorbonne University, Paris, France. raphaele.renardpenna@gmail.com. 9. Academic Department of Radiology, Hopital Tenon, AP-HP, Sorbonne University, Paris, France. raphaele.renardpenna@gmail.com. 10. GRC5, ONCOTYPE-Uro, Institut Universitaire de Cancérologie, F-75020, Paris, France. raphaele.renardpenna@gmail.com.
Abstract
PURPOSE: To assess the added value of the dynamic contrast-enhanced sequence (DCE) to combination T2-weighted imaging (T2w) + diffusion-weighted imaging (DWI) in detecting prostate cancer (PCa) recurrence after HIFU (high-intensity focused ultrasound). METHODS: Forty-five males with clinical and biological suspected PCa recurrence were retrospectively selected. All underwent multi-parametric MRI (mpMRI) before biopsies. Two readers independently assigned a Likert score of cancer likelihood on T2w + DWI + DCE and T2w + DWI images. Prostatic biopsies were taken as the gold standard. RESULTS: Recurrent PCa was identified at biopsy for 37 patients (82%). Areas under the receiver-operating curve of T2w + DWI and T2w + DWI + DCE imaging were not significantly different for both readers. Using a Likert score ≥ 3 for the PCa diagnosis threshold, sensitivity at the lobe level for the (1) senior and (2) junior reader for T2w +DWI +DCE sensitivity was (1) 0.97 and (2) 0.94 vs. (1) 0.94 and (2) 0.97 for T2w + DWI. CONCLUSION: Accuracy of mpMRI was not significantly improved by adding DCE to T2w + DWI. Sensitivity was high for T2w + DWI + DCE and T2w + DWI with no significant difference for either the junior or senior reader. KEY POINTS: • MpMRI has the capability to detect PCa recurrence in post-HIFU monitoring. • The sensitivity of T2w and DWI for detecting PCa recurrence was not improved by DCE. • Readers with different degrees of experience did not improve their performance with DCE.
PURPOSE: To assess the added value of the dynamic contrast-enhanced sequence (DCE) to combination T2-weighted imaging (T2w) + diffusion-weighted imaging (DWI) in detecting prostate cancer (PCa) recurrence after HIFU (high-intensity focused ultrasound). METHODS: Forty-five males with clinical and biological suspected PCa recurrence were retrospectively selected. All underwent multi-parametric MRI (mpMRI) before biopsies. Two readers independently assigned a Likert score of cancer likelihood on T2w + DWI + DCE and T2w + DWI images. Prostatic biopsies were taken as the gold standard. RESULTS: Recurrent PCa was identified at biopsy for 37 patients (82%). Areas under the receiver-operating curve of T2w + DWI and T2w + DWI + DCE imaging were not significantly different for both readers. Using a Likert score ≥ 3 for the PCa diagnosis threshold, sensitivity at the lobe level for the (1) senior and (2) junior reader for T2w +DWI +DCE sensitivity was (1) 0.97 and (2) 0.94 vs. (1) 0.94 and (2) 0.97 for T2w + DWI. CONCLUSION: Accuracy of mpMRI was not significantly improved by adding DCE to T2w + DWI. Sensitivity was high for T2w + DWI + DCE and T2w + DWI with no significant difference for either the junior or senior reader. KEY POINTS: • MpMRI has the capability to detect PCa recurrence in post-HIFU monitoring. • The sensitivity of T2w and DWI for detecting PCa recurrence was not improved by DCE. • Readers with different degrees of experience did not improve their performance with DCE.
Entities:
Keywords:
Contrast media; Diffusion magnetic resonance imaging; High-intensity focused ultrasound ablation; Neoplasm recurrence, local; Prostate cancer
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