Louise Carton1, Baptiste Pignon2, Alexandre Baguet3, Imane Benradia4, Jean-Luc Roelandt4, Guillaume Vaiva5, Pierre Thomas5, Ali Amad5, Philippe De Timary6, Mickaël Naassila7, Pierre A Geoffroy8, Benjamin Rolland9. 1. Univ Lille, Inserm, CHU de Lille, UMR_S1171 and Service de Pharmacologie Médicale, F-59000 Lille, France; CHU Lille Service d'Addictologie et de Psychiatrie, France. Electronic address: louise.carton@univ-lille2.fr. 2. AP-HP, DHU PePSY, Hôpitaux Universitaires Henri-Mondor, Pôle de Psychiatrie, Créteil, 94000, France; INSERM, U955, Team 15, Créteil, 94000, France; Fondation FondaMental, Créteil, 94000, France; UPEC, Université Paris-Est, Faculté de Médecine, Créteil, 94000, France. 3. Service d'Addictologie, CHU de Rouen, Rouen, France, INSERM, U1073, Rouen, France, Institut de Recherche et d'Innovation en Biomedecine, Université de Normandie, Rouen, France. 4. Centre Collaborateur de l'Organisation Mondiale de la Santé-CCOMS (Lille, France), EPSM Lille Métropole, France; Inserm, UMR 1123-ECEVE-Université Paris Diderot, France. 5. Univ. Lille, CNRS UMR 9193-PsyCHIC-SCALab & CHU Lille, Department of Psychiatry, F-59000 Lille, France. 6. Service Psychiatrie Adulte et Institut de Neurosciences, Clinique universitaire Saint Luc, Université catholique de Louvain, Avenue Hippocrate 10, B1200 Bruxelles, Belgium. 7. Univ Picardie Jules Verne, Centre Universitaire de Recherche en Santé, INSERM U1247 Unit, Research Group on Alcohol and Pharmacodependences (GRAP), Amiens, France. 8. Fondation FondaMental, Créteil, 94000, France; Inserm, U1144, Paris F-75006, France; Université Paris Diderot, Sorbonne Paris Cité, UMR-S 1144, Paris F-75013, France; AP-HP, GH Saint-Louis-Lariboisière-F. Widal, Pôle de Psychiatrie et de Médecine Addictologique, 75475 Paris Cedex 10, France. 9. Service Universitaire d'Addictologie de Lyon (SUAL), Pôle MOPHA, CH Le Vinatier, 69500 Bron, France; Univ Lyon; UCBL; CRNL; Inserm U1028; CNRS UMR5292, 69678 Bron, France.
Abstract
BACKGROUND: To compare the symptom patterns of major depressive disorder (MDD) among subjects with MDD and 1) no alcohol use disorder (AUD), 2) alcohol abuse and 3) alcohol dependence, respectively. METHODS: In a general population survey of 38,694 French individuals, MDD and AUDs were assessed using the Mini International Neuropsychiatric Interview 5.0.0 (MINI). A total of 4339 subjects (11.2%) in the sample met the criteria for MDD. Among them, 413 (9.5%) AUD subjects were identified: 138 (3.2%) for alcohol abuse and 275 (6.3%) for alcohol dependence. The associations of each of the ten MDD criteria of the MINI and psychiatric clinical features were compared among the three groups. The relative profiles of 'MDD + AUD' vs. 'MDD alone' were determined using a multivariable stepwise regression model. RESULTS: With the noAUD group as the reference, sadness (OR = 0.46; 95%CI, 0.29-0.74) and anhedonia (OR = 1.66; 95%CI, 1.06-2.73) were only associated with alcohol abuse. Sleep disorders (OR = 2.07; 95%CI, 1.51-2.88), feelings of guilt (OR = 1.41; 95%CI, 1.05-1.90), diminished concentration/indecisiveness (OR = 1.52; 95%CI, 1.12-2.07) and thoughts of death (OR = 1.95; 95%CI 1.49-2.55) were only associated with alcohol dependence. Weight or appetite variations were both associated with alcohol abuse (OR = 1.7; 95%CI, 1.15-2.53) and dependence (OR = 1.41; 95%CI, 1.06-1.88). Bipolar disorder and PTSD were only associated with alcohol dependence. Psychotic features, previous suicide attempts, and panic disorder were more frequent in the MDD-AUD group. CONCLUSION: MDD-AUD subjects displayed a more severe profile with specific symptomatology and comorbidity profiles compared to MDD-only subjects.
BACKGROUND: To compare the symptom patterns of major depressive disorder (MDD) among subjects with MDD and 1) no alcohol use disorder (AUD), 2) alcohol abuse and 3) alcohol dependence, respectively. METHODS: In a general population survey of 38,694 French individuals, MDD and AUDs were assessed using the Mini International Neuropsychiatric Interview 5.0.0 (MINI). A total of 4339 subjects (11.2%) in the sample met the criteria for MDD. Among them, 413 (9.5%) AUD subjects were identified: 138 (3.2%) for alcohol abuse and 275 (6.3%) for alcohol dependence. The associations of each of the ten MDD criteria of the MINI and psychiatric clinical features were compared among the three groups. The relative profiles of 'MDD + AUD' vs. 'MDD alone' were determined using a multivariable stepwise regression model. RESULTS: With the noAUD group as the reference, sadness (OR = 0.46; 95%CI, 0.29-0.74) and anhedonia (OR = 1.66; 95%CI, 1.06-2.73) were only associated with alcohol abuse. Sleep disorders (OR = 2.07; 95%CI, 1.51-2.88), feelings of guilt (OR = 1.41; 95%CI, 1.05-1.90), diminished concentration/indecisiveness (OR = 1.52; 95%CI, 1.12-2.07) and thoughts of death (OR = 1.95; 95%CI 1.49-2.55) were only associated with alcohol dependence. Weight or appetite variations were both associated with alcohol abuse (OR = 1.7; 95%CI, 1.15-2.53) and dependence (OR = 1.41; 95%CI, 1.06-1.88). Bipolar disorder and PTSD were only associated with alcohol dependence. Psychotic features, previous suicide attempts, and panic disorder were more frequent in the MDD-AUD group. CONCLUSION:MDD-AUD subjects displayed a more severe profile with specific symptomatology and comorbidity profiles compared to MDD-only subjects.
Authors: Jennifer B Dwyer; Argyris Stringaris; David A Brent; Michael H Bloch Journal: J Child Psychol Psychiatry Date: 2020-02-04 Impact factor: 8.982
Authors: Honghuang Lin; Fan Wang; Andrew J Rosato; Lindsay A Farrer; David C Henderson; Huiping Zhang Journal: Epigenomics Date: 2020-06-04 Impact factor: 4.778