Prevalence, Demographic, and Clinical Correlates of Comorbid Depressive Symptoms in Chinese Psychiatric Patients With Alcohol Dependence.

BACKGROUND: Depressive symptoms are common among psychiatric patients with alcohol dependence (AD). However, the prevalence and clinical correlates of comorbid depressive symptoms are less well studied in Chinese Han patients.
METHODS: In this hospital-based survey, we recruited 378 psychiatric patients diagnosed with AD according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV). All patients completed the Beck Depression Inventory (BDI) to evaluate depressive symptoms and the Alcohol Use Disorders Identification Test (AUDIT) to assess the severity of drinking.
RESULTS: Compared to patients without depressive symptoms, 48.9% (185/378) of the patients with comorbid depressive symptoms were younger, had a more unstable marital status, had a higher AUDIT total score, and had a higher adverse consequences subscore (all P < 0.05). Further logistic regression analysis showed that unstable marital status (Odds ratios [OR] = 2.20, 95% confidence interval [CI] 1.21-3.99) and AUDIT total score (OR=1.07, 95% CI 1.03-1.11) were significantly associated with depressive symptoms.
CONCLUSIONS: Our findings indicate high comorbidity between AD and depressive symptoms in Chinese psychiatric patients. Moreover, some variables are correlates of comorbid depressive symptoms. Particular attention should be paid to the early detection and intervention for this comorbid condition and its risk factors.

Introduction

Alcohol dependence (AD) and depression commonly co-occur (1, 2). The prevalence of their co-occurrence in individuals with AD fluctuates markedly, according to how depressive symptoms are measured or defined. Epidemiologic data showed that the comorbidity rate in the general population varied between 15% and 28% (1, 3–5), whereas in clinical samples, this rate was much higher, ranging from 43% to 48% (6, 7). Moreover, AD is significantly associated with depression. For example, Lai et al. conducted a meta-analysis of 22 community-based studies and found that the pooled odds ratio for AD and major depression was 3.09 (95% confidence interval [CI] 2.38–4.03) (8). In another hospital-based survey, alcohol abuse was strongly associated with depressive symptoms (OR 2.58, 95% CI 1.51–4.40) (9).

Comorbid depression in AD patients is associated with an increased risk of suicide attempts, relapse, treatment dropouts, and life dissatisfaction (10–12). For instance, earlier studies reported that compared with subjects with depression only, AD patients with depression had a suicide-specific standardized mortality ratio that was approximately two times higher, as well as more frequent episodes and more severe depression symptomatology (13–15). A more recent study showed that the co-occurrence of AD and depression negatively impacted quality of life and worsened physical functioning (16). Furthermore, AD aggravated the symptoms and prolonged the course of depression (17, 18). Two longitudinal studies revealed that problematic alcohol use increased the likelihood of persistent depression (19), and a reduction in drinking decreased the risk of depression (20). In turn, depressive symptoms heightened problem drinking and the risk of a relapse of AD (21). In summary, AD poses a potent risk for the development of depression and vice versa (22–24).

However, previous studies regarding comorbid depressive symptoms in AD patients were conducted in Western or African countries (6, 7, 25). To date, no published data on the prevalence and clinical correlates of comorbid depressive symptoms in AD patients in the Chinese Han population are available. Therefore, we conducted the present study to investigate the prevalence of and factors associated with depressive symptoms in AD patients in China.

Materials and Methods

Subjects

This study was conducted in eight hospitals with the psychiatric department in China. These eight hospitals are as follows: the Second Xiangya Hospital of Central South University, Henan Mental Hospital, Peking University Sixth Hospital, Shanghai Mental Health Center, West China Hospital of Sichuan University, Nanjing Brain Hospital, Hubei General Hospital, and the First Affiliated Hospital of Xian Jiaotong University. They are located in northern, northwestern, southwestern, central-southern, and eastern China. Therefore, our sample can represent Chinese hospitals to some extent. Patients were recruited from consecutive admissions to the psychiatric department of these eight hospitals in China. The inclusion criteria for the study were that the patients aged≥18 years, and the patients had the diagnosis of AD which was made by trained psychiatrists according to the DSM-IV criterion for alcohol dependence. A total of 413 patients met the inclusion criteria. However, 35 patients were excluded because they refused to participate in the whole study and could not complete the whole interview. Finally, 378 patients were enrolled and interviewed. These patients completed our self-developed questionnaire for demographic characteristics and drinking patterns, the BDI for depressive symptoms and the AUDIT for the severity of drinking.

The Institutional Review Board at the Second Xiangya Hospital of Central South University approved this study and all patients gave informed consent for participating in the study.

Instruments

We used a self-developed questionnaire to assess 378 patients for demographic characteristics (gender, age, years of education, marital status, employment status, and monthly family income), and drinking patterns (age at first drink, daily consumption of pure alcohol, types of alcoholic beverages, and frequency of drinking).The Beck Depression Inventory (BDI) is a 21-item inventory that measures symptoms of depression. Based on the BDI total score, patients were classified into two groups: ≤13 = not depressed and ≥14 = depressed. Mild depression was defined as a total score of 14–19. Moderate depression was defined as a total score of 20–28, and severe depression was defined as a total score of 29 or above on the BDI (26). Suicidal ideation was measured using item I about suicide of the BDI (I don't have any thoughts of killing myself; I have thoughts of killing myself, but I would not carry them out; I would like to kill myself; I would kill myself if I had the chance). The Alcohol Use Disorders Identification Test (AUDIT) is a screening tool with 10 items about recent alcohol use, alcohol dependence symptoms, and alcohol-related problems. The maximum score of the AUDIT is 40 points. The AUDIT consists of two factors: a consumption factor (items 1–3) and an adverse consequence of drinking factor (items 4–10) (27, 28). The AUDIT has been standardized and validated for the Chinese population (29). The 10-item AUDIT-Chinese version was used in this study. Both the BDI and AUDIT were administered by trained and experienced psychiatrists. The diagnosis of AD was made for each participant by two trained psychiatrists according to the DSM-IV criterion for alcohol dependence, which requires three or more dependence items in twelve months (30).

Statistical Analysis

All data were analyzed by SPSS version 20.0 for Windows. Testing for normality was accomplished by Kolmogorov-Smirnov one-sample test. Continuous data were presented as the mean ± standard deviation. The daily consumption data of pure alcohol were described as the median and interquartile range because these data were non-normally distributed. Categorical data were shown as frequencies and percentages. Differences in continuous variables were compared using Student's t-test, and categorical variables were compared using the chi-squared test. Logistic regression analysis with backward Wald method was used to compare depression and non-depression among the AD patients after controlling for the related variables (gender, age, marital status, years of education, employment status, monthly family income, age at first drink, and AUDIT total score). The significance level was set at P < 0.05.

Results

The Prevalence of Comorbid Depressive Symptoms in AD Patients

A total of 185 (48.9%, 95% CI: 43.9–54.0%) of 378 AD patients met the criteria for depressive symptoms (BDI total score ≥14), and 193 (52.1%) did not. Eighty (43.2%) of the 185 patients met the criteria for mild depressive symptoms, and 105 (56.8%) of the 185 patients met the criteria for moderate or severe depressive symptoms. Importantly, 19.6% (74/378) of the sample reported the presence of suicidal ideation. A total of 37.3% (69/185) of patients with comorbid depressive symptoms had suicidal ideation; the rate was 2.6% in patients without depressive symptoms. The difference in suicidal ideation between these two groups was significant (χ2 = 72.379, P < 0.001) ().

Table 1

Demographic and clinical features between the alcohol dependence (AD) patients with and without depression.

Characteristics	Depression(n= 185)	Non-depression(n= 193)	t/χ2	P
Males/females	171/14	187/6	3.747	0.053
Age (years)	41.8 ± 9.9	44.1 ± 10.0	2.182	0.030
Education (years)	11.0 ± 3.5	11.0 ± 3.6	0.127	0.899
Marital status			10.233	0.001
Stable	137 (74.1%)	168 (87.0%)
Unstable	48 (25.9%)	25 (13.0%)
Employment status			0.508	0.476
Employed	134 (72.4%)	146 (75.6%)
Unemployed	51 (27.6%)	47 (24.4%)
Monthly family income(US$)			3.193	0.203
<$446	82 (44.6%)	102 (53.7%)
$446~$744	77 (41.8%)	68 (35.8%)
>$744	25 (13.6%)	20 (10.5%)
Age at first drink (years)	18.6 ± 4.9	18.4 ± 4.7	0.395	0.693
BDI- suicidal ideation	69 (37.3%)	5 (2.6%)	72.379	<0.001
AUDIT score
Consumption subscore	11.2 ± 1.4	11.0 ± 1.6	0.802	0.423
Adverse consequences subscore	18.1 ± 5.6	15.8 ± 6.0	3.713	<0.001
Total score	29.3 ± 6.2	26.9 ± 6.6	3.575	<0.001

Demographic Characteristics and Drinking Patterns of AD Patients

The whole sample consisted of 358 (94.7%) men and 20 (5.3%) women (male: female ratio=17.9:1.0). The mean age was 43.0 ± 10.0 years (men: 43.2 ± 9.7; women: 38.4 ± 13.4; t = 2.140, P=0.033), and the mean years of education was 11.0 ± 3.6 years (men: 11.0 ± 3.6; women: 11.9 ± 2.7; t = 1.193, P = 0.234). A total of 80.7% of the patients had a stable marital status, and 74.1% were employed.

Two hundred sixty-five (70.1%) of the patients drank alcoholic beverages at least once a day, 59 (15.6%) consumed 4–6/week, and 32 (8.5%) consumed 2–3/week. The median (interquartile range) daily consumption of pure alcohol was 100.8 g (59.4–168.0 g). A total of 378 patients consumed 61.4% of their alcohol in the form of strong distilled spirits (50% ethanol or above), 25.4% in the form of weaker distilled spirits (32%–45% ethanol), 9.8% in the form of beer, 2.1% in the form of rice wine, and 1.4% in the form of “other” beverages.

Mean scores on the AUDIT were as follows: consumption subscore, 11.1 ± 1.5; adverse consequences subscore, 17.0 ± 5.9; and total AUDIT score, 28.1 ± 6.5.

Factors Associated With Comorbid Depressive Symptoms in AD Patients

As presented in , compared with those patients without depressive symptoms, those with depressive symptoms were younger, had more unstable marital status, had higher scores for the adverse consequences factor and had higher AUDIT total score (all P < 0.05). After adjustments were made for related factors (gender, age, marital status, years of education, employment status, monthly family income, age at first drink, and AUDIT total score), further logistic regression analysis with backward Wald method indicated that unstable marital status (OR=2.20, 95% CI 1.21–3.99, Waldχ2 = 6.670, P=0.010) and AUDIT total score (OR=1.07, 95% CI 1.03–1.11, Waldχ2 = 12.207, P < 0.001) remained significantly associated with comorbid depressive symptoms ().

Table 2

Risk factors generated by logistic regression analysis with depression as dependent variable.

	B	SE	Waldχ2	P	OR	95% CI
Marital status	0.786	0.304	6.670	0.010	2.20	1.21-3.99
AUDIT total score	0.068	0.019	12.207	<0.001	1.07	1.03-1.11
(Constant)	-0.601	1.165	0.266	0.606	–	–

Discussion

To the best of our knowledge, the present study is the first national hospital-based survey to investigate the prevalence and demographic and clinical correlates of comorbid depressive symptoms in patients with AD in a Chinese Han population. We found that 48.9% of AD patients were depressed and that 56.8% of those depressed patients were moderate or severe depressed, suggesting a highly prevalent and serious depressive symptoms among AD patients. We also observed that the significant risk factors for depression in this population were unstable marital status and the AUDIT total score.

Our finding that the co-occurrence prevalence of depressive symptoms was 48.9% in AD patients closely corresponds with the findings of hospital-based studies conducted in other countries. For example, Ugochukwu et al. reported that the prevalence of major depression among 470 patients with alcohol use disorder was 45.8% in a tertiary hospital in Nigeria (6). Another study conducted by Odlaug and colleagues showed that the rate of depression among 2,979 AD patients was 43.1% in eight European countries (7). This consistency of results across multiple countries indicates a stable and high comorbidity of AD and depression. However, one recent survey employing the BDI revealed a much lower prevalence (24.7%) of depressive symptoms, with a cut-off of 21 points in Serbian patients with harmful alcohol use (31). This variation may be attributed to the inconsistent definitions of depression and alcohol use.

Importantly, many studies conducted in individuals from community populations also reported the comorbidity rate between AD and depression. For instance, according to the National Comorbidity Survey Replication, the prevalence of the co-occurrence of AD and major depression was 21.0% (1). In the Australian National Survey of Mental Health and Well Being, Burns and Teesson discovered that the prevalence of depression among residents with AD was 28% (5). One study conducted by Caetano in Puerto Rico reported that among those with alcohol use disorder, the rate of major depression was 23% (25). Another survey showed that the prevalence of depression in Nigerian college students with AD was 23.8% (4). In a prospective study, Briere et al. reported that the rate of cumulative alcohol use disorder and major depression comorbidity was 21% (12). The prevalence of depressive symptoms in AD patients was significantly higher than that in the general population, which might be explained by the greater severity of AD in hospital-based populations than in community-based populations. AD patients in psychiatric settings have more severe dependence symptoms, more life dissatisfaction, fewer family bonds, and worse social functioning and support than do community dwelling individuals (16). Therefore, the likelihood of AD patients developing depression is much higher than that of the general population. Further research conducted in both hospitals and communities at the same time is needed.

Recent evidence suggests that AD is associated with a significant risk of developing depression. According to Grant et al., the association between AD and depression was strong (OR=4.24, 95% CI 3.51–5.13) (3). Grant and colleagues updated this result in the National Epidemiologic Survey on Alcohol and Related Conditions, and found that the DSM-5 based alcohol use disorder was significantly correlated with major depression (OR=1.3, 95% CI 1.15–1.39) (32). Moreover, one study performed by Bazargan-Hejazi in a hospital in Los Angeles showed that alcohol abuse was associated with depressive symptoms, with an OR of 2.58(95% CI 1.51–4.40) (9). Furthermore, a meta-analysis of 22 studies conducted in non-clinical populations found that the pooled odds ratio for AD and major depression was 3.09 (95% CI 2.38–4.03) (8). Boden reviewed the literature and revealed that the presence of alcohol use disorder doubled the risk of major depression (33). Although the phenomenon of AD and depression comorbidity has been widely reported, the potential mechanisms underlying their association remain a controversial topic. Several possible explanations might account for the comorbidity between AD and depression. First, AD may precipitate the depressive symptoms caused by the pharmacological effects of alcohol. Moreover, AD patients may experience depressive symptoms as a result of a prolonged period of abstinence (31). Second, depression may occur as an emotional reaction to the adverse consequences of AD, such as unemployment (33–35). Third, individuals with depression drink alcohol for self-medication to alleviate depressive symptoms and eventually develop AD (36, 37). Finally, AD and depressive symptoms may occur simultaneously or develop independently due to shared biopsychosocial or genetic predisposition factors, such as poverty, genetic predisposition, or neuroimmune mechanisms (34). Many studies (38–42) found genetic overlap between AD and depression, suggesting that shared genetic liability possibly explains their comorbidity. For instance, Muench reported that the risk variant rs10514299 of major depressive disorder predicts the reward process of AD (39). Moreover, according to the survey from Zhou et al., SEMA3A variation was correlated with comorbid AD and major depression (41). Furthermore, studies have also found a neuroimmune interface in AD and depression comorbidity (43, 44). The mechanisms of comorbidity between AD and depression merit further investigation with a large sample size.

Previous studies (9, 25, 45–47) have revealed female gender, younger age, divorced or single status, unemployment, age at first drink, and severity of drinking problems to be independent predictors of comorbid depressive symptoms among patients with AD. In our study, gender, age, educational attainment, employment status, monthly family income, and age at first drink were not significantly associated with comorbid depression in logistic regression analysis. The potential reasons might be due to the relatively small sample size or recall bias, which need to be further studied. Consistent with other research, we found that unstable marital status and AUDIT total score were risk factors for the comorbidity of AD and depressive symptoms. For instance, according to the survey from Caetano et al., the severity of alcohol use disorder was positively correlated with the likelihood of major depression, and the AUDIT total score indicates the severity of drinking problems (25). Regarding marital status, studies report that marriage disruption was a powerful risk factor for major depression (48). Moreover, Hasin et al. observed that being widowed, separated, and divorced increased the risk of depression (46). The present study indicates an urgent need to provide psychotherapy to AD patients who are unstable in marriage or drinking too much to prevent the development of depression.

The present study found that gender had no significant relationship with AD patients with and without depression due to the relatively small sample size of female patients. Earlier studies showed that male gender is a protective factor against depression (25). One survey in patients with AD indicated that female patients showed more depressive symptoms than male patients did (45). Moreover, Cornelius et al. reported that the proportion of women was greater among depressed patients with AD than among non-depressed patients with AD (49). Another study discovered that among individuals with AD, women reported more depression than men did (50). The meta-analysis conducted by Conner concluded that among individuals with alcohol use disorder, women experienced more severe depressive symptoms than men did (47). In the general population, the rate of depression was higher among women than that among men (46, 51). We will enlarge the sample size to better illustrate the gender difference between AD patients with and without depression in the future.

We found that 19.6% of AD patients had suicidal ideation, and the rate (37.3%) was much higher in patients with comorbid depressive symptoms. Our result was consistent with previous studies. For example, Ziolkowski et al. reported that 12% of 510 patients with AD had suicidal ideation, and comorbidity with depressive symptoms increased the likelihood of suicidal thoughts (52). According to the study from Cornelius et al., depressed alcoholics had a much higher risk of suicidality than non-depressed alcoholics (49). Furthermore, one survey revealed that more than half of the patients with alcohol use disorder had engaged in at least one suicide attempt (53). Hence, clinicians should pay particular attention to AD patients with depression and offer a variety of interventions to prevent potential suicidal behaviors.

We observed that AD patients were more common among males than females, and the male/female ratio of AD patients (17.9) was especially striking. Our findings corresponded to those of earlier studies (32, 54, 55). For example, Hasin et al. reported that AD was significantly more prevalent in male adults (55). Furthermore, men consumed more alcohol and were more likely than women to drink harmfully (56, 57). Interestingly, we also observed that female AD patients were younger than male AD patients. Many studies have confirmed that although women had later onset of drinking, they developed AD more rapidly than men (58–60). The possible explanations for such gender differences in AD patients are biological factors, such as different alcohol pharmacokinetics and their effects on the brain and different levels of sex hormones (57). Moreover, sociocultural factors might also play an important role, including different tolerances of social drinking, socioeconomic status and social networks (61, 62).

The strength of our study is that it is multi-centered and was conducted in eight hospitals in China. Therefore, it could represent hospitals at different levels from diverse parts of China. This study also has several limitations. First, although the DSM-IV criterion for alcohol dependence was used, the diagnosis of major depressive disorder was not established. Depressive symptoms were identified only based on the BDI. Second, this study was cross-sectional. Therefore, the potential causality and direction between AD and depression could not be ascertained. Longitudinal studies are needed to elucidate this relationship. Third, some of our data were abstained by self-report. Hence, recall bias was unavoidable. Fourth, information about clinical factors, such as psychiatric comorbidity, duration of treatment and history of hospitalization, were not collected. Further research on these clinical factors and their association with depressive symptoms will be needed.

In conclusion, comorbid depressive symptoms are quite common among AD patients in China. Moreover, depression is associated with unstable marital status and the AUDIT total score. Considering the potential adverse consequences, particularly the high rate of suicidal ideation in patients with depressive symptoms, more attention needs to be devoted to the early detection and intervention of comorbid depressive symptoms in patients with AD.

Data Availability Statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

Ethics Statement

The studies involving human participants were reviewed and approved by The Institutional Review Board at the Second Xiangya Hospital of Central South University. The patients/participants provided their written informed consent to participate in this study.

Author Contributions

WH designed the study. HH, ZZ, HC, KN, RuZ, WS, BL, HJ, WW, JD, MZ, ZY, JL, RoZ, SL, SX, XW, WF, and CG collected the sample and performed the literature review. HH and ZZ conducted the analyses and wrote the initial version of this manuscript. All authors edited, read, and approved the last version of this manuscript.

Funding

This study was supported by the National Natural Science Foundation of China (Grant No.81901351), the Natural Science Foundation of Hubei Province of China (Grant No. 2019CFB269), the Health Commission of Hubei Province scientific research project (Grant No. WJ2019H352), and the Wuhan Municipal Health Commission scientific research project (Grant No. WX19Q05).

Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.