Literature DB >> 2961677

Issues in analysis of data on paternal age and 47,+21: implications for genetic counseling for Down syndrome.

E B Hook1.   

Abstract

Data and analyses on paternal age and 47,+21 are reviewed. It is concluded that there are few, if any, grounds to justify the inference of a paternal age effect independent of maternal age for those paternal age-maternal age combinations on which there are prenatal diagnostic data. It is suggested that genetic counseling as to increased (or decreased) risk of Down syndrome associated with various paternal ages is not justified at present.

Mesh：

Year:  1987        PMID： 2961677     DOI： 10.1007/bf00291414

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  22 in total

1.  Differences in maternal age-specific rates of Down syndrome between Jews of European origin and of North African or Asian origin.

Authors:  E B Hook; S Harlap
Journal:  Teratology       Date:  1979-10

2.  An analysis of paternal age and 47,+21 in 35,000 new prenatal cytogenetic diagnosis data from the New York State Chromosome Registry: no significant effect.

Authors:  P K Cross; E B Hook
Journal:  Hum Genet       Date:  1987-12       Impact factor: 4.132

3.  A reanalysis of the New York State prenatal diagnosis data on Down's syndrome and paternal age effects.

Authors:  E Stene; J Stene; S Stengel-Rutkowski
Journal:  Hum Genet       Date:  1987-12       Impact factor: 4.132

Review 4.  The genetic control of meiosis.

Authors:  B S Baker; A T Carpenter; M S Esposito; R E Esposito; L Sandler
Journal:  Annu Rev Genet       Date:  1976       Impact factor: 16.830

5.  Parental age and unbalanced Robertsonian translocations associated with Down syndrome and Patau syndrome: comparison with maternal and paternal age effects for 47, +21 and 47, +13.

Authors:  E B Hook
Journal:  Ann Hum Genet       Date:  1984-10       Impact factor: 1.670

6.  An analysis for paternal-age effect in Ohio's Down syndrome births, 1970-1980.

Authors:  G O Roecker; C A Huether
Journal:  Am J Hum Genet       Date:  1983-11       Impact factor: 11.025

7.  Paternal age and Down's syndrome genotypes diagnosed prenatally: no association in New York state data.

Authors:  E B Hook; P K Cross
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

8.  Evidence for genetic control of nondisjunction in man.

Authors:  O S Alfi; R Chang; S P Azen
Journal:  Am J Hum Genet       Date:  1980-07       Impact factor: 11.025

9.  Paternal age and Down syndrome.

Authors:  J D Erickson
Journal:  Am J Hum Genet       Date:  1979-07       Impact factor: 11.025

10.  Maternal-age effect in aneuploidy: does altered embryonic selection play a role?

Authors:  S Aymé; A Lippman-Hand
Journal:  Am J Hum Genet       Date:  1982-07       Impact factor: 11.025
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  9 in total

1.  Controversy concerning paternal age effect in 47,+21 Down's syndrome.

Authors:  E Stene; J Stene
Journal:  Hum Genet       Date:  1989-02       Impact factor: 4.132

2.  Parental age and the origin of trisomy 21. A study of 302 families.

Authors:  F Dagna Bricarelli; M Pierluigi; M Landucci; A Arslanian; D A Coviello; M A Ferro; P Strigini
Journal:  Hum Genet       Date:  1989-04       Impact factor: 4.132

3.  Parental-age effects in Down syndrome.

Authors:  Santhosh Girirajan
Journal:  J Genet       Date:  2009-04       Impact factor: 1.166

4.  Factual, statistical and logical issues in the search for a paternal age effect for Down syndrome.

Authors:  E B Hook; P K Cross; R R Regal
Journal:  Hum Genet       Date:  1990-08       Impact factor: 4.132

5.  An analysis of paternal age and 47,+21 in 35,000 new prenatal cytogenetic diagnosis data from the New York State Chromosome Registry: no significant effect.

Authors:  P K Cross; E B Hook
Journal:  Hum Genet       Date:  1987-12       Impact factor: 4.132

6.  On methodological issues regarding 47,+21 paternal age data.

Authors:  E Stene; J Stene; S Stengel-Rutkowski
Journal:  Hum Genet       Date:  1987-12       Impact factor: 4.132

7.  Controversy concerning paternal age effect in 47, + 21 Down's syndrome.

Authors:  A D Carothers
Journal:  Hum Genet       Date:  1988-04       Impact factor: 4.132

8.  Periodic health examination, 1996 update: 1. Prenatal screening for and diagnosis of Down syndrome. Canadian Task Force on the Periodic Health Examination.

Authors:  P T Dick
Journal:  CMAJ       Date:  1996-02-15       Impact factor: 8.262

Review 9.  The male biological clock.

Authors:  Sarah M Lambert; Puneet Masson; Harry Fisch
Journal:  World J Urol       Date:  2006-12       Impact factor: 3.661
  9 in total

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