| Literature DB >> 29607181 |
Mario Mascalchi1, Camilla E Comin2, Elena Bertelli1, Lapo Sali1, Cristina Maddau3, Stefania Zuccherelli1, Giulia Picozzi3, Laura Carrozzi4, Michela Grazzini5, Gabriella Fontanini6, Luca Voltolini7, Alessandra Vella8, Francesca Castiglione2, Francesca Carozzi3, Eugenio Paci3, Maurizio Zompatori9, Andrea Lopes Pegna10, Fabio Falaschi11.
Abstract
Occurrence of multiple primary lung cancers (MPLC) in individuals undergoing low-dose computed tomography (LDCT) screening has not been thoroughly addressed. We investigated MPLC in subjects recruited in the ITALUNG randomized clinical trial. Cases of cytologically/histologically proven MPLC detected at screening LDCT or follow-up CT were selected and pathologically re-evaluated according to the WHO 2015 classification. Overall 16 MPLC were diagnosed at screening LDCT (n=14, all present at baseline) or follow-up CT (n=2) in six subjects (4 in one subject, 3 in two and 2 in three subjects), representing 0.43% of the 1,406 screenees and 15.8% of the 38 subjects with at least one screen-detected primary lung cancer. MPLC included 9 adenocarcinomas in three subjects and a combination of 7 different tumour histotypes in three subjects. MPLC, mostly adenocarcinomas, are not uncommon in smokers and ex-smokers with at least one LDCT screen detected primary lung cancer.Entities:
Keywords: Multiple primary lung cancer; adenocarcinoma; low-dose CT screening; lung cancer
Year: 2018 PMID： 29607181 PMCID： PMC5864678 DOI： 10.21037/jtd.2018.01.95
Source DB: PubMed Journal: J Thorac Dis ISSN： 2072-1439 Impact factor: 2.895