PURPOSE: The aim of this study was to assess the clinical feasibility, image quality, and radiation dose implications of 0.25-mm imaging mode in a cohort of humans, achieved by dividing the photon-counting detector (PCD) size in half compared with standard-resolution photon-counting computed tomography (CT) (0.5 mm). METHODS: In this technical feasibility study, a whole-body prototype PCD-CT scanner was studied in the 0.25 mm detector mode (measured at isocenter). A high-resolution PCD-CT protocol was first tested in phantom and canine studies in terms of image noise and spatial resolution. Then, 8 human subjects (mean age, 58 ± 8 years; 2 men) underwent axial PCD 0.25-mm scans of the brain, the thorax, and at the level of the upper left kidney. Filtered backprojection reconstruction was performed with a sharp kernel (B70) for standard-resolution and high-resolution data at 0.5-mm isotropic image voxel. High-resolution data, in addition, were reconstructed with an ultrasharp kernel (U70) at 0.25-mm isotropic voxels. RESULTS: Image reconstructions from the PCD 0.25-mm detector system led to an improvement in resolution from 9 to 18 line pairs/cm in a line pair phantom. Modulation transfer function improved from 9.5 to 15.8 line pairs/cm at 10% modulation transfer function. When fully exploiting this improvement, image noise increased by 75% compared with dose-matched 0.5-mm slice PCD standard-resolution acquisition. However, when comparing with standard-resolution data at same in-plane resolution and slice thickness, the PCD 0.25-mm detector mode showed 19% less image noise in phantom, animal, and human scans. CONCLUSION: High-resolution photon-counting CT in humans showed improved image quality in terms of spatial resolution and image noise compared with standard-resolution photon-counting.
PURPOSE: The aim of this study was to assess the clinical feasibility, image quality, and radiation dose implications of 0.25-mm imaging mode in a cohort of humans, achieved by dividing the photon-counting detector (PCD) size in half compared with standard-resolution photon-counting computed tomography (CT) (0.5 mm). METHODS: In this technical feasibility study, a whole-body prototype PCD-CT scanner was studied in the 0.25 mm detector mode (measured at isocenter). A high-resolution PCD-CT protocol was first tested in phantom and canine studies in terms of image noise and spatial resolution. Then, 8 human subjects (mean age, 58 ± 8 years; 2 men) underwent axial PCD 0.25-mm scans of the brain, the thorax, and at the level of the upper left kidney. Filtered backprojection reconstruction was performed with a sharp kernel (B70) for standard-resolution and high-resolution data at 0.5-mm isotropic image voxel. High-resolution data, in addition, were reconstructed with an ultrasharp kernel (U70) at 0.25-mm isotropic voxels. RESULTS: Image reconstructions from the PCD 0.25-mm detector system led to an improvement in resolution from 9 to 18 line pairs/cm in a line pair phantom. Modulation transfer function improved from 9.5 to 15.8 line pairs/cm at 10% modulation transfer function. When fully exploiting this improvement, image noise increased by 75% compared with dose-matched 0.5-mm slice PCD standard-resolution acquisition. However, when comparing with standard-resolution data at same in-plane resolution and slice thickness, the PCD 0.25-mm detector mode showed 19% less image noise in phantom, animal, and human scans. CONCLUSION: High-resolution photon-counting CT in humans showed improved image quality in terms of spatial resolution and image noise compared with standard-resolution photon-counting.
Authors: Ehsan Abadi; Brian Harrawood; Jayasai R Rajagopal; Shobhit Sharma; Anuj Kapadia; William Paul Segars; Karl Stierstorfer; Martin Sedlmair; Elizabeth Jones; Ehsan Samei Journal: Biomed Phys Eng Express Date: 2019-08-09
Authors: N R van der Werf; P A Rodesch; S Si-Mohamed; R W van Hamersvelt; M J W Greuter; T Leiner; L Boussel; M J Willemink; P Douek Journal: Eur Radiol Date: 2022-01-08 Impact factor: 5.315
Authors: Kishore Rajendran; Martin Petersilka; André Henning; Elisabeth R Shanblatt; Bernhard Schmidt; Thomas G Flohr; Andrea Ferrero; Francis Baffour; Felix E Diehn; Lifeng Yu; Prabhakar Rajiah; Joel G Fletcher; Shuai Leng; Cynthia H McCollough Journal: Radiology Date: 2021-12-14 Impact factor: 11.105
Authors: Francis I Baffour; Kishore Rajendran; Katrina N Glazebrook; Jamison E Thorne; Nicholas B Larson; Shuai Leng; Cynthia H McCollough; Joel G Fletcher Journal: Eur Radiol Date: 2022-06-11 Impact factor: 7.034
Authors: E Wehrse; L Klein; L T Rotkopf; W L Wagner; M Uhrig; C P Heußel; C H Ziener; S Delorme; S Heinze; M Kachelrieß; H-P Schlemmer; S Sawall Journal: Radiologe Date: 2021-02-17 Impact factor: 0.635
Authors: Jayasai R Rajagopal; Pooyan Sahbaee; Faraz Farhadi; Justin B Solomon; Juan Carlos Ramirez-Giraldo; William F Pritchard; Bradford J Wood; Elizabeth C Jones; Ehsan Samei Journal: IEEE Trans Radiat Plasma Med Sci Date: 2020-08-27