AIM: Shift workers have a high risk of cardiovascular disease (CVD). Systemic inflammation measured has been associated with the risk of CVD onset, in addition to classical risk factors. However, the association between work schedule and inflammatory cytokine levels remains unclear. The purpose of this study was to examine the association between work schedule and interleukin-6 (IL-6)/high-sensitivity C-reactive protein (hs-CRP) levels among Japanese workers. METHODS: The present cross-sectional study was a part of the Japanese Study of Health, Occupation and Psychosocial Factors Related Equity (J-HOPE). A total of 5259 persons who measured inflammatory cytokine were analyzed in this study. One-way analysis of variance was used to test log-transformed IL-6/hs-CRP differences by work schedule. Multiple regression analysis was used to examine the difference adjusted for other possible CVD risk factors. RESULTS: There were 3660 participants who had a regular work schedule; the remaining schedules were shift work without night work for 181 participants, shift work with night work for 1276 participants, and only night work for 142 participants. The unadjusted model showed that only night workers were significantly related to high levels of IL-6 compared with regular workers. Even in the multiple regression analysis, the higher level of IL-6 among only night workers remained significant (β=0.058, P=0.01). On the contrary, hs-CRP was not. CONCLUSION: The present study revealed that only night shift work is significantly associated with high levels of IL-6 in Japanese workers. These observations help us understand the mechanism for the association between work schedule and CVD onset.
AIM: Shift workers have a high risk of cardiovascular disease (CVD). Systemic inflammation measured has been associated with the risk of CVD onset, in addition to classical risk factors. However, the association between work schedule and inflammatory cytokine levels remains unclear. The purpose of this study was to examine the association between work schedule and interleukin-6 (IL-6)/high-sensitivity C-reactive protein (hs-CRP) levels among Japanese workers. METHODS: The present cross-sectional study was a part of the Japanese Study of Health, Occupation and Psychosocial Factors Related Equity (J-HOPE). A total of 5259 persons who measured inflammatory cytokine were analyzed in this study. One-way analysis of variance was used to test log-transformed IL-6/hs-CRP differences by work schedule. Multiple regression analysis was used to examine the difference adjusted for other possible CVD risk factors. RESULTS: There were 3660 participants who had a regular work schedule; the remaining schedules were shift work without night work for 181 participants, shift work with night work for 1276 participants, and only night work for 142 participants. The unadjusted model showed that only night workers were significantly related to high levels of IL-6 compared with regular workers. Even in the multiple regression analysis, the higher level of IL-6 among only night workers remained significant (β=0.058, P=0.01). On the contrary, hs-CRP was not. CONCLUSION: The present study revealed that only night shift work is significantly associated with high levels of IL-6 in Japanese workers. These observations help us understand the mechanism for the association between work schedule and CVD onset.
Entities:
Keywords:
CVD; Interleukin-6; J-HOPE; Night work; Work schedule
Authors: M Maes; C Song; A Lin; R De Jongh; A Van Gastel; G Kenis; E Bosmans; I De Meester; I Benoy; H Neels; P Demedts; A Janca; S Scharpé; R S Smith Journal: Cytokine Date: 1998-04 Impact factor: 3.861
Authors: Céline Vetter; Elizabeth E Devore; Lani R Wegrzyn; Jennifer Massa; Frank E Speizer; Ichiro Kawachi; Bernard Rosner; Meir J Stampfer; Eva S Schernhammer Journal: JAMA Date: 2016-04-26 Impact factor: 56.272
Authors: L M Biasucci; A Vitelli; G Liuzzo; S Altamura; G Caligiuri; C Monaco; A G Rebuzzi; G Ciliberto; A Maseri Journal: Circulation Date: 1996-09-01 Impact factor: 29.690
Authors: Mark Hamer; Severine Sabia; G David Batty; Martin J Shipley; Adam G Tabák; Archana Singh-Manoux; Mika Kivimaki Journal: Circulation Date: 2012-08-13 Impact factor: 29.690
Authors: Manav V Vyas; Amit X Garg; Arthur V Iansavichus; John Costella; Allan Donner; Lars E Laugsand; Imre Janszky; Marko Mrkobrada; Grace Parraga; Daniel G Hackam Journal: BMJ Date: 2012-07-26
Authors: Jeffrey A Haspel; Ron Anafi; Marishka K Brown; Nicolas Cermakian; Christopher Depner; Paula Desplats; Andrew E Gelman; Monika Haack; Sanja Jelic; Brian S Kim; Aaron D Laposky; Yvonne C Lee; Emmanuel Mongodin; Aric A Prather; Brian J Prendergast; Colin Reardon; Albert C Shaw; Shaon Sengupta; Éva Szentirmai; Mahesh Thakkar; Wendy E Walker; Laura A Solt Journal: JCI Insight Date: 2020-01-16
Authors: Marit Skogstad; Asgeir Mamen; Lars-Kristian Lunde; Bente Ulvestad; Dagfinn Matre; Hans Christian D Aass; Reidun Øvstebø; Pia Nielsen; Kari N Samuelsen; Øivind Skare; Per Anton Sirnes Journal: Int J Environ Res Public Health Date: 2019-02-12 Impact factor: 3.390
Authors: Dagfinn Matre; Per Anton Sirnes; Elisabeth Goffeng; Øivind Skare; Marit Skogstad Journal: Int J Environ Res Public Health Date: 2022-02-10 Impact factor: 3.390