BACKGROUND: Inflammatory processes are putative mechanisms underlying the cardioprotective effects of physical activity. An inverse association between physical activity and inflammation has been demonstrated, but no long-term prospective data are available. We therefore examined the association between physical activity and inflammatory markers over a 10-year follow-up period. METHODS AND RESULTS: Participants were 4289 men and women (mean age, 49.2 years) from the Whitehall II cohort study. Self-reported physical activity and inflammatory markers (serum high-sensitivity C-reactive protein and interleukin-6) were measured at baseline (1991) and follow-up (2002). Forty-nine percent of the participants adhered to standard physical activity recommendations for cardiovascular health (2.5 h/wk moderate to vigorous physical activity) across all assessments. Physically active participants at baseline had lower C-reactive protein and interleukin-6 levels, and this difference remained stable over time. Compared with participants who rarely adhered to physical activity guidelines over the 10-year follow-up, the high-adherence group displayed lower log(e) C-reactive protein (β=-0.07; 95% confidence interval, -0.12 to -0.02) and log(e) interleukin-6 (β=-0.07; 95% confidence interval, -0.10 to -0.03) at follow-up after adjustment for a range of covariates. Compared with participants who remained stable, those who reported an increase in physical activity of at least 2.5 h/wk displayed lower log(e) C-reactive protein (β coefficient=-0.05; 95% confidence interval, -0.10 to -0.001) and log(e) interleukin-6 (β coefficient=-0.06; 95% confidence interval, -0.09 to -0.03) at follow-up. CONCLUSIONS: Regular physical activity is associated with lower markers of inflammation over 10 years of follow-up and thus may be important in preventing the proinflammatory state seen with aging.
BACKGROUND: Inflammatory processes are putative mechanisms underlying the cardioprotective effects of physical activity. An inverse association between physical activity and inflammation has been demonstrated, but no long-term prospective data are available. We therefore examined the association between physical activity and inflammatory markers over a 10-year follow-up period. METHODS AND RESULTS: Participants were 4289 men and women (mean age, 49.2 years) from the Whitehall II cohort study. Self-reported physical activity and inflammatory markers (serum high-sensitivity C-reactive protein and interleukin-6) were measured at baseline (1991) and follow-up (2002). Forty-nine percent of the participants adhered to standard physical activity recommendations for cardiovascular health (2.5 h/wk moderate to vigorous physical activity) across all assessments. Physically active participants at baseline had lower C-reactive protein and interleukin-6 levels, and this difference remained stable over time. Compared with participants who rarely adhered to physical activity guidelines over the 10-year follow-up, the high-adherence group displayed lower log(e) C-reactive protein (β=-0.07; 95% confidence interval, -0.12 to -0.02) and log(e) interleukin-6 (β=-0.07; 95% confidence interval, -0.10 to -0.03) at follow-up after adjustment for a range of covariates. Compared with participants who remained stable, those who reported an increase in physical activity of at least 2.5 h/wk displayed lower log(e) C-reactive protein (β coefficient=-0.05; 95% confidence interval, -0.10 to -0.001) and log(e) interleukin-6 (β coefficient=-0.06; 95% confidence interval, -0.09 to -0.03) at follow-up. CONCLUSIONS: Regular physical activity is associated with lower markers of inflammation over 10 years of follow-up and thus may be important in preventing the proinflammatory state seen with aging.
Authors: Tina Wenz; Susana G Rossi; Richard L Rotundo; Bruce M Spiegelman; Carlos T Moraes Journal: Proc Natl Acad Sci U S A Date: 2009-11-16 Impact factor: 11.205
Authors: Gary O'Donovan; Anthony J Blazevich; Colin Boreham; Ashley R Cooper; Helen Crank; Ulf Ekelund; Kenneth R Fox; Paul Gately; Billie Giles-Corti; Jason M R Gill; Mark Hamer; Ian McDermott; Marie Murphy; Nanette Mutrie; John J Reilly; John M Saxton; Emmanuel Stamatakis Journal: J Sports Sci Date: 2010-04 Impact factor: 3.337
Authors: Robert Dantzer; Jason C O'Connor; Gregory G Freund; Rodney W Johnson; Keith W Kelley Journal: Nat Rev Neurosci Date: 2008-01 Impact factor: 34.870
Authors: Karla M Pou; Joseph M Massaro; Udo Hoffmann; Ramachandran S Vasan; Pal Maurovich-Horvat; Martin G Larson; John F Keaney; James B Meigs; Izabella Lipinska; Sekar Kathiresan; Joanne M Murabito; Christopher J O'Donnell; Emelia J Benjamin; Caroline S Fox Journal: Circulation Date: 2007-08-20 Impact factor: 29.690
Authors: Tina E Brinkley; Xiaoyan Leng; Michael E Miller; Dalane W Kitzman; Marco Pahor; Michael J Berry; Anthony P Marsh; Stephen B Kritchevsky; Barbara J Nicklas Journal: J Gerontol A Biol Sci Med Sci Date: 2009-02-04 Impact factor: 6.053
Authors: Daniel I Swerdlow; Michael V Holmes; Karoline B Kuchenbaecker; Jorgen E L Engmann; Tina Shah; Reecha Sofat; Yiran Guo; Christina Chung; Anne Peasey; Roman Pfister; Simon P Mooijaart; Helen A Ireland; Maarten Leusink; Claudia Langenberg; Ka Wah Li; Jutta Palmen; Philip Howard; Jackie A Cooper; Fotios Drenos; John Hardy; Michael A Nalls; Yun Rose Li; Gordon Lowe; Marlene Stewart; Suzette J Bielinski; Julian Peto; Nicholas J Timpson; John Gallacher; Malcolm Dunlop; Richard Houlston; Ian Tomlinson; Ioanna Tzoulaki; Jian'an Luan; Jolanda M A Boer; Nita G Forouhi; N Charlotte Onland-Moret; Yvonne T van der Schouw; Renate B Schnabel; Jaroslav A Hubacek; Ruzena Kubinova; Migle Baceviciene; Abdonas Tamosiunas; Andrzej Pajak; Roman Topor-Madry; Sofia Malyutina; Damiano Baldassarre; Bengt Sennblad; Elena Tremoli; Ulf de Faire; Luigi Ferrucci; Stefania Bandenelli; Toshiko Tanaka; James F Meschia; Andrew Singleton; Gerjan Navis; Irene Mateo Leach; Stephan J L Bakker; Ron T Gansevoort; Ian Ford; Stephen E Epstein; Mary Susan Burnett; Joe M Devaney; J Wouter Jukema; Rudi G J Westendorp; Gert Jan de Borst; Yolanda van der Graaf; Pim A de Jong; Anke-Hilse Mailand-van der Zee; Olaf H Klungel; Anthonius de Boer; Pieter A Doevendans; Jeffrey W Stephens; Charles B Eaton; Jennifer G Robinson; JoAnn E Manson; F Gerry Fowkes; Timonthy M Frayling; Jackie F Price; Peter H Whincup; Richard W Morris; Debbie A Lawlor; George Davey Smith; Yoav Ben-Shlomo; Susan Redline; Leslie A Lange; Meena Kumari; Nick J Wareham; W M Monique Verschuren; Emelia J Benjamin; John C Whittaker; Anders Hamsten; Frank Dudbridge; J A Chris Delaney; Andrew Wong; Diana Kuh; Rebecca Hardy; Berta Almoguera Castillo; John J Connolly; Pim van der Harst; Eric J Brunner; Michael G Marmot; Christina L Wassel; Steve E Humphries; Philippa J Talmud; Mika Kivimaki; Folkert W Asselbergs; Mikhail Voevoda; Martin Bobak; Hynek Pikhart; James G Wilson; Hakon Hakonarson; Alex P Reiner; Brendan J Keating; Naveed Sattar; Aroon D Hingorani; Juan Pablo Casas Journal: Lancet Date: 2012-03-14 Impact factor: 79.321
Authors: Stephen Kaptoge; Emanuele Di Angelantonio; Gordon Lowe; Mark B Pepys; Simon G Thompson; Rory Collins; John Danesh Journal: Lancet Date: 2009-12-22 Impact factor: 79.321
Authors: Jennifer A Sumner; Qixuan Chen; Andrea L Roberts; Ashley Winning; Eric B Rimm; Paola Gilsanz; M Maria Glymour; Shelley S Tworoger; Karestan C Koenen; Laura D Kubzansky Journal: Biol Psychiatry Date: 2017-06-27 Impact factor: 13.382
Authors: Heather M Derry; Avelina C Padin; Jennifer L Kuo; Spenser Hughes; Janice K Kiecolt-Glaser Journal: Curr Psychiatry Rep Date: 2015-10 Impact factor: 5.285
Authors: Martina Luchetti; James M Barkley; Yannick Stephan; Antonio Terracciano; Angelina R Sutin Journal: Psychoneuroendocrinology Date: 2014-09-02 Impact factor: 4.905
Authors: Priya Palta; Gerardo Heiss; A Richey Sharrett; Kelley Pettee Gabriel; Keenan Walker; Kelly R Evenson; David Knopman; Thomas H Mosley; Dean F Wong; Rebecca F Gottesman Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472
Authors: James A Blumenthal; Patrick J Smith; Stephanie Mabe; Alan Hinderliter; Kathleen Welsh-Bohmer; Jeffrey N Browndyke; Pao-Hwa Lin; William Kraus; P Murali Doraiswamy; James Burke; Andrew Sherwood Journal: Psychosom Med Date: 2017 Jul/Aug Impact factor: 4.312
Authors: Sarah C Van Alsten; Charles S Rabkin; Norie Sawada; Taichi Shimazu; Hadrien Charvat; Taiki Yamaji; Manami Inoue; Troy J Kemp; Ligia A Pinto; M Constanza Camargo; Shoichiro Tsugane; Minkyo Song Journal: Cancer Epidemiol Biomarkers Prev Date: 2020-05-28 Impact factor: 4.254