| Literature DB >> 31941836 |
Jeffrey A Haspel1, Ron Anafi2, Marishka K Brown3, Nicolas Cermakian4, Christopher Depner5, Paula Desplats6,7, Andrew E Gelman8, Monika Haack9, Sanja Jelic10, Brian S Kim11,12,13,14,15, Aaron D Laposky3, Yvonne C Lee16, Emmanuel Mongodin17, Aric A Prather18, Brian J Prendergast19, Colin Reardon20, Albert C Shaw21, Shaon Sengupta22,23, Éva Szentirmai24, Mahesh Thakkar25,26, Wendy E Walker27, Laura A Solt28.
Abstract
Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses - ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation -are mediated in a time of day-dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, "Sleep Insufficiency, Circadian Misalignment, and the Immune Response," to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.Entities:
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Year: 2020 PMID： 31941836 PMCID： PMC7030790 DOI： 10.1172/jci.insight.131487
Source DB: PubMed Journal: JCI Insight ISSN： 2379-3708