| Literature DB >> 29550489 |
Ruinian Zheng1, Shunhuan Lin1, Ling Guan2, Huiling Yuan3, Kejun Liu4, Chun Liu1, Weibiao Ye4, Yuting Liao4, Jun Jia5, Ruopeng Zhang6.
Abstract
Long non-coding RNA (lncRNA) is an important member of non-coding RNA family and emerging evidence has indicated that it plays a pivotal role in many physiological and pathological processes. The lncRNA X inactive specific transcript (XIST) is a potential tumour suppressor in some types of cancers. However, the expression and function of XIST in breast cancer remain largely unclear. The objective of this study was to evaluate the expression and biological role of XIST in breast cancer. The results showed that XIST was significantly down-regulated in breast cancer tissues and cell lines. Further functional analysis indicated that overexpression of XIST remarkably inhibited breast cancer cell growth, migration, and invasion. The results of luciferase reporter assays verified that miR-155 was a direct target of XIST in breast cancer. Moreover, caudal-type homeobox 1 (CDX1) was identified as a direct target of miR-155 and miR-155/CDX1 rescued the effects of XIST in breast cancer cells. Taken together, our results suggest that XIST is down-regulated in breast cancer and suppresses breast cancer cell growth, migration, and invasion via the miR-155/CDX1 axis.Entities:
Keywords: Breast cancer; Caudal-type homeobox 1; X inactive specific transcript; miRNA-155
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Year: 2018 PMID： 29550489 DOI： 10.1016/j.bbrc.2018.03.104
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575