Literature DB >> 30685833

The Ambivalent Role of lncRNA Xist in Carcinogenesis.

Yung-Kang Chen1,2, Yun Yen3,4,5,6.   

Abstract

Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice. However, this phenomenon is not consistent in humans as growing evidence suggests Xist can suppress or promote cancer growth in different organs of the human body. In this review, we discuss recent advances of XCI in human embryonic stem cells and provide an explanation for the seemingly contradictory roles of Xist in development of human cancer.

Entities:  

Keywords:  Cancer stem cell; Competing endogenous RNA; Exosomes; Long non-coding RNA; MicroRNAs; X Chromosome inactivation; XACT non-coding RNA; XIST non-coding RNA

Mesh：

Substances：

Year:  2019        PMID： 30685833     DOI： 10.1007/s12015-019-9871-z

Source DB:  PubMed          Journal:  Stem Cell Rev Rep        ISSN： 2629-3277            Impact factor:   5.739


  82 in total

1.  Chromosomal silencing and localization are mediated by different domains of Xist RNA.

Authors:  Anton Wutz; Theodore P Rasmussen; Rudolf Jaenisch
Journal:  Nat Genet       Date:  2002-01-07       Impact factor: 38.330

2.  Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse.

Authors:  N Takagi; M Sasaki
Journal:  Nature       Date:  1975-08-21       Impact factor: 49.962

3.  BRCA1 supports XIST RNA concentration on the inactive X chromosome.

Authors:  Shridar Ganesan; Daniel P Silver; Roger A Greenberg; Dror Avni; Ronny Drapkin; Alexander Miron; Samuel C Mok; Voahangy Randrianarison; Steven Brodie; Jennifer Salstrom; Theodore P Rasmussen; Ann Klimke; Christine Marrese; York Marahrens; Chu Xia Deng; Jean Feunteun; David M Livingston
Journal:  Cell       Date:  2002-11-01       Impact factor: 41.582

4.  Epigenetic dynamics of imprinted X inactivation during early mouse development.

Authors:  Ikuhiro Okamoto; Arie P Otte; C David Allis; Danny Reinberg; Edith Heard
Journal:  Science       Date:  2003-12-11       Impact factor: 47.728

Review 5.  Sex determination: where environment and genetics meet.

Authors:  David Crews
Journal:  Evol Dev       Date:  2003 Jan-Feb       Impact factor: 1.930

6.  Species differences in TSIX/Tsix reveal the roles of these genes in X-chromosome inactivation.

Authors:  Barbara R Migeon; Catherine H Lee; Ashis K Chowdhury; Heather Carpenter
Journal:  Am J Hum Genet       Date:  2002-05-21       Impact factor: 11.025

7.  Gene action in the X-chromosome of the mouse (Mus musculus L.).

Authors:  M F LYON
Journal:  Nature       Date:  1961-04-22       Impact factor: 49.962

8.  The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.

Authors:  Isaiah J Fidler
Journal:  Nat Rev Cancer       Date:  2003-06       Impact factor: 60.716

9.  Gene expression profiles of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers.

Authors:  Amir A Jazaeri; Cindy J Yee; Christos Sotiriou; Kelly R Brantley; Jeff Boyd; Edison T Liu
Journal:  J Natl Cancer Inst       Date:  2002-07-03       Impact factor: 13.506

10.  Skewing X chromosome choice by modulating sense transcription across the Xist locus.

Authors:  Tatyana B Nesterova; Colette M Johnston; Ruth Appanah; Alistair E T Newall; Jonathan Godwin; Maria Alexiou; Neil Brockdorff
Journal:  Genes Dev       Date:  2003-09-01       Impact factor: 11.361
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  8 in total

Review 1.  Emerging role of competing endogenous RNA and associated noncoding RNAs in thyroid cancer.

Authors:  Qian Bai; Zhenjie Pan; Ghulam Nabi; Farooq Rashid; Yang Liu; Suliman Khan
Journal:  Am J Cancer Res       Date:  2022-03-15       Impact factor: 6.166

2.  Identification and functional analysis of LncRNA-XIST ceRNA network in prostate cancer.

Authors:  Jie Wang; Jie Huang; Yingxue Guo; Yuli Fu; Yifang Cao; Kang Zhou; Jianxiong Ma; Bodong Lv; Wenjie Huang
Journal:  BMC Cancer       Date:  2022-08-29       Impact factor: 4.638

Review 3.  The Emerging Role of Major Regulatory RNAs in Cancer Control.

Authors:  Xiaofeng Dai; Aman Chandra Kaushik; Jianying Zhang
Journal:  Front Oncol       Date:  2019-09-24       Impact factor: 6.244

4.  Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma.

Authors:  Kasper Thystrup Karstensen; Aleks Schein; Andreas Petri; Martin Bøgsted; Karen Dybkær; Shizuka Uchida; Sakari Kauppinen
Journal:  Noncoding RNA       Date:  2020-12-28

5.  Extracellular vesicle expansion of PMIS-miR-210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism.

Authors:  Steven Eliason; Liu Hong; Yan Sweat; Camille Chalkley; Huojun Cao; Qi Liu; Hank Qi; Hongwei Xu; Fenghuang Zhan; Brad A Amendt
Journal:  Clin Transl Med       Date:  2022-09

Review 6.  The role of lncRNAs and XIST in oral cancer.

Authors:  Huimin Liu; Dongxu Wang; Shaoning Kan; Ming Hao; Lu Chang; Pengxu Lu; Yangyang Liu; Ye Jin; Weiwei Liu
Journal:  Front Cell Dev Biol       Date:  2022-08-10

7.  Identification and Validation of a Potential Prognostic 7-lncRNA Signature for Predicting Survival in Patients with Multiple Myeloma.

Authors:  Yun Zhong; Zhe Liu; Dangchi Li; Qinyuan Liao; Jingao Li
Journal:  Biomed Res Int       Date:  2020-11-05       Impact factor: 3.411

Review 8.  Sex Dimorphism in Pulmonary Hypertension: The Role of the Sex Chromosomes.

Authors:  Daria S Kostyunina; Paul McLoughlin
Journal:  Antioxidants (Basel)       Date:  2021-05-14
  8 in total

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