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Literature DB >> 29535137

LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3.

Buqing Ye¹, Benyu Liu^1,2, Liuliu Yang^1,2, Xiaoxiao Zhu^3,4, Dongdong Zhang⁴, Wei Wu^2,4, Pingping Zhu¹, Yanying Wang¹, Shuo Wang¹, Pengyan Xia¹, Ying Du¹, Shu Meng^3,4, Guanling Huang^1,2, Jiayi Wu^1,2, Runsheng Chen⁵, Yong Tian^6,4, Zusen Fan^7,2.

Abstract

Divergent long noncoding RNAs (lncRNAs) represent a major lncRNA biotype in mouse and human genomes. The biological and molecular functions of the divergent lncRNAs remain largely unknown. Here, we show that lncKdm2b, a divergent lncRNA for Kdm2b gene, is conserved among five mammalian species and highly expressed in embryonic stem cells (ESCs) and early embryos. LncKdm2b knockout impairs ESC self-renewal and causes early embryonic lethality. LncKdm2b can activate Zbtb3 by promoting the assembly and ATPase activity of Snf2-related CREBBP activator protein (SRCAP) complex in trans Zbtb3 potentiates the ESC self-renewal in a Nanog-dependent manner. Finally, Zbtb3 deficiency impairs the ESC self-renewal and early embryonic development. Therefore, our findings reveal that lncRNAs may represent an additional layer of the regulation of ESC self-renewal and early embryogenesis.

Entities: Disease Gene Species

Keywords: zzm321990LncKdm2bzzm321990; zzm321990SRCAPzzm321990; ESC pluripotency; Zbtb3; embryogenesis

Mesh：

Substances：

Year: 2018 PMID： 29535137 PMCID： PMC5897780 DOI： 10.15252/embj.201797174

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

46 in total

Review 1. POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function.

Authors: Sung-Uk Lee; Takahiro Maeda
Journal: Immunol Rev Date: 2012-05 Impact factor: 12.988

2. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses.

Authors: Moran N Cabili; Cole Trapnell; Loyal Goff; Magdalena Koziol; Barbara Tazon-Vega; Aviv Regev; John L Rinn
Journal: Genes Dev Date: 2011-09-02 Impact factor: 11.361

3. Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.

Authors: Bin Shen; Wensheng Zhang; Jun Zhang; Jiankui Zhou; Jianying Wang; Li Chen; Lu Wang; Alex Hodgkins; Vivek Iyer; Xingxu Huang; William C Skarnes
Journal: Nat Methods Date: 2014-03-02 Impact factor: 28.547

4. Functional Divergence of the Nuclear Receptor NR2C1 as a Modulator of Pluripotentiality During Hominid Evolution.

Authors: Jennifer L Baker; Katherine A Dunn; Joseph Mingrone; Bernard A Wood; Beverly A Karpinski; Chet C Sherwood; Derek E Wildman; Thomas M Maynard; Joseph P Bielawski
Journal: Genetics Date: 2016-04-13 Impact factor: 4.562

Review 5. lincRNAs: genomics, evolution, and mechanisms.

Authors: Igor Ulitsky; David P Bartel
Journal: Cell Date: 2013-07-03 Impact factor: 41.582

6. Local regulation of gene expression by lncRNA promoters, transcription and splicing.

Authors: Jesse M Engreitz; Jenna E Haines; Elizabeth M Perez; Glen Munson; Jenny Chen; Michael Kane; Patrick E McDonel; Mitchell Guttman; Eric S Lander
Journal: Nature Date: 2016-10-26 Impact factor: 49.962

Review 7. Long noncoding RNAs: cellular address codes in development and disease.

Authors: Pedro J Batista; Howard Y Chang
Journal: Cell Date: 2013-03-14 Impact factor: 41.582

8. Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.

Authors: Alessandro Tosi; Caroline Haas; Franz Herzog; Andrea Gilmozzi; Otto Berninghausen; Charlotte Ungewickell; Christian B Gerhold; Kristina Lakomek; Ruedi Aebersold; Roland Beckmann; Karl-Peter Hopfner
Journal: Cell Date: 2013-09-12 Impact factor: 41.582

9. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.

Authors: Thomas Derrien; Rory Johnson; Giovanni Bussotti; Andrea Tanzer; Sarah Djebali; Hagen Tilgner; Gregory Guernec; David Martin; Angelika Merkel; David G Knowles; Julien Lagarde; Lavanya Veeravalli; Xiaoan Ruan; Yijun Ruan; Timo Lassmann; Piero Carninci; James B Brown; Leonard Lipovich; Jose M Gonzalez; Mark Thomas; Carrie A Davis; Ramin Shiekhattar; Thomas R Gingeras; Tim J Hubbard; Cedric Notredame; Jennifer Harrow; Roderic Guigó
Journal: Genome Res Date: 2012-09 Impact factor: 9.043

10. Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms.

Authors: Elsayed E Ibrahim; Roya Babaei-Jadidi; Anas Saadeddin; Bradley Spencer-Dene; Sina Hossaini; Mohammed Abuzinadah; Ningning Li; Wakkas Fadhil; Mohammad Ilyas; Dominique Bonnet; Abdolrahman S Nateri
Journal: Stem Cells Date: 2012-10 Impact factor: 6.277

23 in total

1. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.

Authors: Buqing Ye; Liuliu Yang; Guomin Qian; Benyu Liu; Xiaoxiao Zhu; Pingping Zhu; Jing Ma; Wei Xie; Huimu Li; Tianku Lu; Yanying Wang; Shuo Wang; Ying Du; Zhimin Wang; Jing Jiang; Jinsong Li; Dongdong Fan; Shu Meng; Jiayi Wu; Yong Tian; Zusen Fan
Journal: EMBO J Date: 2020-05-25 Impact factor: 11.598

10. Long noncoding RNA AFAP1‑AS1 enhances cell proliferation and invasion in osteosarcoma through regulating miR‑4695‑5p/TCF4‑β‑catenin signaling.

Authors: Rongrui Li; Shichen Liu; Yao Li; Qingxi Tang; Yunchuan Xie; Raosheng Zhai
Journal: Mol Med Rep Date: 2018-06-05 Impact factor: 2.952

LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3.

Review 1. POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function.

2. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses.

3. Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.

4. Functional Divergence of the Nuclear Receptor NR2C1 as a Modulator of Pluripotentiality During Hominid Evolution.

Review 5. lincRNAs: genomics, evolution, and mechanisms.

6. Local regulation of gene expression by lncRNA promoters, transcription and splicing.

Review 7. Long noncoding RNAs: cellular address codes in development and disease.

8. Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.

9. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.

10. Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms.

1. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.

2. SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.

3. Long non-coding RNA LINC01410 promotes colon cancer cell proliferation and invasion by inhibiting miR-3128.

4. lncRNA PART1 Promotes Breast Cancer Cell Progression by Directly Targeting miR-4516.

5. LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3.

6. The long non-coding RNA Snhg3 is essential for mouse embryonic stem cell self-renewal and pluripotency.

Review 7. Non-Coding RNAs and Nucleosome Remodeling Complexes: An Intricate Regulatory Relationship.

8. LINC00210 as a miR-328-5p sponge promotes nasopharyngeal carcinoma tumorigenesis by activating NOTCH3 pathway.

9. Long noncoding RNA EZR-AS1 promotes tumor growth and metastasis by modulating Wnt/β-catenin pathway in breast cancer.

10. Long noncoding RNA AFAP1‑AS1 enhances cell proliferation and invasion in osteosarcoma through regulating miR‑4695‑5p/TCF4‑β‑catenin signaling.