PURPOSE: The aim of this study was to verify whether the distribution of a treatment diary by a pharmacist could influence the adherence to oral treatment with imatinib, nilotinib, and dasatinib in patients with chronic myeloid leukaemia. METHODS: The level of adherence was calculated using the received daily dose/prescribed daily dose ratio and compared between patients who used a diary and those who did not. RESULTS: Forty-four (35.8%) of 123 patients with chronic myeloid leukaemia completed the diary: 20 (45.4%) receiving imatinib, 17 (38.6%) receiving nilotinib, and seven (15.9%) receiving dasatinib. Treatment adherence with the diary calculated using received daily dose/prescribed daily dose method was 93.6% (imatinib 94.9%, nilotinib 91.1%, and dasatinib 95.8%). Adherence during the period without a diary was 86.5% (84.9, 87.4, and 90%). Adherence was significantly greater with than without a diary (p < 0.0001). CONCLUSIONS: The findings of this study that, in the case of chronic diseases, direct pharmacist-patient contact is important in order to maintain high levels of adherence, and a treatment diary is a valid means of doing this. According to these data, it is necessary to support similar patient-oriented programmes in order to ensure high levels of adherence and optimize drug management.
PURPOSE: The aim of this study was to verify whether the distribution of a treatment diary by a pharmacist could influence the adherence to oral treatment with imatinib, nilotinib, and dasatinib in patients with chronic myeloid leukaemia. METHODS: The level of adherence was calculated using the received daily dose/prescribed daily dose ratio and compared between patients who used a diary and those who did not. RESULTS: Forty-four (35.8%) of 123 patients with chronic myeloid leukaemia completed the diary: 20 (45.4%) receiving imatinib, 17 (38.6%) receiving nilotinib, and seven (15.9%) receiving dasatinib. Treatment adherence with the diary calculated using received daily dose/prescribed daily dose method was 93.6% (imatinib 94.9%, nilotinib 91.1%, and dasatinib 95.8%). Adherence during the period without a diary was 86.5% (84.9, 87.4, and 90%). Adherence was significantly greater with than without a diary (p < 0.0001). CONCLUSIONS: The findings of this study that, in the case of chronic diseases, direct pharmacist-patient contact is important in order to maintain high levels of adherence, and a treatment diary is a valid means of doing this. According to these data, it is necessary to support similar patient-oriented programmes in order to ensure high levels of adherence and optimize drug management.
Authors: Shoshana M Rosenberg; Keith J Petrie; Annette L Stanton; Lan Ngo; Emma Finnerty; Ann H Partridge Journal: J Natl Cancer Inst Date: 2020-05-01 Impact factor: 13.506
Authors: Terry C Davis; Connie L Arnold; Glenn Mills; Glenn J Lesser; W Mark Brown; Richard Schulz; Kathryn E Weaver; Pamala A Pawloski Journal: Int J Environ Res Public Health Date: 2021-10-21 Impact factor: 4.614
Authors: Irene D Lin; Matthew B Shotts; Ahmad Al-Hader; Kellie Jones Weddle; Richard J Holden; Emily L Mueller; Monica R Macik; Mirian Ramirez; Ephrem Abebe Journal: PLoS One Date: 2022-09-22 Impact factor: 3.752
Authors: Christel C L M Boons; Lonneke Timmers; Jeroen J W M Janssen; Peter E Westerweel; Nicole M A Blijlevens; Willem M Smit; Imke H Bartelink; Janneke A Wilschut; Eleonora L Swart; N Harry Hendrikse; Jacqueline G Hugtenburg Journal: Eur J Clin Pharmacol Date: 2020-06-02 Impact factor: 2.953