Literature DB >> 29411841

Real-time monitoring of the aggregation of Alzheimer's amyloid-β via1H magic angle spinning NMR spectroscopy.

Jian Wang1, Tomoya Yamamoto, Jia Bai, Sarah J Cox, Kyle J Korshavn, Martine Monette, Ayyalusamy Ramamoorthy.   

Abstract

Proton magic-angle-spinning NMR used for real-time analysis of amyloid aggregation reveals that mechanical rotation of Aβ1-40 monomers increases the rate of formation of aggregates, and that the increasing lag-time with peptide concentration suggests the formation of growth-incompetent species. EGCG's ability to shift off-pathway aggregation is also demonstrated.

Entities:  

Year:  2018        PMID： 29411841      PMCID： PMC5820189          DOI： 10.1039/c8cc00167g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  30 in total

Review 1.  The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.

Authors:  Iryna Benilova; Eric Karran; Bart De Strooper
Journal:  Nat Neurosci       Date:  2012-01-29       Impact factor: 24.884

2.  Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at critical concentrations of IAPP.

Authors:  Jeffrey R Brender; Janarthanan Krishnamoorthy; Michele F M Sciacca; Subramanian Vivekanandan; Luisa D'Urso; Jennifer Chen; Carmelo La Rosa; Ayyalusamy Ramamoorthy
Journal:  J Phys Chem B       Date:  2015-02-03       Impact factor: 2.991

3.  High-Sensitivity Rheo-NMR Spectroscopy for Protein Studies.

Authors:  Daichi Morimoto; Erik Walinda; Naoto Iwakawa; Mayu Nishizawa; Yasushi Kawata; Akihiko Yamamoto; Masahiro Shirakawa; Ulrich Scheler; Kenji Sugase
Journal:  Anal Chem       Date:  2017-07-05       Impact factor: 6.986

4.  Molecular Mechanism for the (-)-Epigallocatechin Gallate-Induced Toxic to Nontoxic Remodeling of Aβ Oligomers.

Authors:  Rashik Ahmed; Bryan VanSchouwen; Naeimeh Jafari; Xiaodan Ni; Joaquin Ortega; Giuseppe Melacini
Journal:  J Am Chem Soc       Date:  2017-08-25       Impact factor: 15.419

5.  Following protein folding in real time using NMR spectroscopy.

Authors:  J Balbach; V Forge; N A van Nuland; S L Winder; P J Hore; C M Dobson
Journal:  Nat Struct Biol       Date:  1995-10

6.  Real-time NMR studies on a transient folding intermediate of barstar.

Authors:  T R Killick; S M Freund; A R Fersht
Journal:  Protein Sci       Date:  1999-06       Impact factor: 6.725

7.  Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives.

Authors:  Tomer Cohen; Anat Frydman-Marom; Meirav Rechter; Ehud Gazit
Journal:  Biochemistry       Date:  2006-04-18       Impact factor: 3.162

Review 8.  The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

Authors:  John Hardy; Dennis J Selkoe
Journal:  Science       Date:  2002-07-19       Impact factor: 47.728

9.  Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution.

Authors:  H LeVine
Journal:  Protein Sci       Date:  1993-03       Impact factor: 6.725

10.  High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification.

Authors:  Samuel A Kotler; Jeffrey R Brender; Subramanian Vivekanandan; Yuta Suzuki; Kazutoshi Yamamoto; Martine Monette; Janarthanan Krishnamoorthy; Patrick Walsh; Meagan Cauble; Mark M Banaszak Holl; E Neil G Marsh; Ayyalusamy Ramamoorthy
Journal:  Sci Rep       Date:  2015-07-03       Impact factor: 4.379
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  8 in total

1.  Zinc boosts EGCG's hIAPP amyloid Inhibition both in solution and membrane.

Authors:  Young-Ho Lee; Yuxi Lin; Sarah J Cox; Misaki Kinoshita; Bikash R Sahoo; Magdalena Ivanova; Ayyalusamy Ramamoorthy
Journal:  Biochim Biophys Acta Proteins Proteom       Date:  2018-11-22       Impact factor: 3.036

2.  Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation.

Authors:  Bikash Ranjan Sahoo; Takuya Genjo; Sarah J Cox; Andrea K Stoddard; G M Anantharamaiah; Carol Fierke; Ayyalusamy Ramamoorthy
Journal:  J Mol Biol       Date:  2018-08-28       Impact factor: 5.469

Review 3.  High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease.

Authors:  Bikash R Sahoo; Sarah J Cox; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2020-04-17       Impact factor: 6.222

4.  Sulfonated Compounds Bind with Prostatic Acid Phosphatase (PAP248-286) to Inhibit the Formation of Amyloid Fibrils.

Authors:  Tingting Zhang; Haikui Yang; Zichao Yang; Suiyi Tan; Jiabin Jin; Shuwen Liu; Jiajie Zhang
Journal:  ChemistryOpen       Date:  2018-06-11       Impact factor: 2.911

Review 5.  High-Speed Atomic Force Microscopy Reveals the Structural Dynamics of the Amyloid-β and Amylin Aggregation Pathways.

Authors:  Takahiro Watanabe-Nakayama; Bikash R Sahoo; Ayyalusamy Ramamoorthy; Kenjiro Ono
Journal:  Int J Mol Sci       Date:  2020-06-16       Impact factor: 5.923

6.  Biophysical Investigation of the Interplay between the Conformational Species of Domain-Swapped GB1 Amyloid Mutant through Real-Time Monitoring of Amyloid Fibrillation.

Authors:  Renuka Ranjan; Nidhi Tiwari; Arvind M Kayastha; Neeraj Sinha
Journal:  ACS Omega       Date:  2021-12-07

7.  Molecular insights into the primary nucleation of polymorphic amyloid β dimers in DOPC lipid bilayer membrane.

Authors:  Olga Press-Sandler; Yifat Miller
Journal:  Protein Sci       Date:  2022-05       Impact factor: 6.725

8.  Site specific NMR characterization of abeta-40 oligomers cross seeded by abeta-42 oligomers.

Authors:  Han-Wen Chang; Ho-I Ma; Yi-Shan Wu; Ming-Che Lee; Eric Chung-Yueh Yuan; Shing-Jong Huang; Yu-Sheng Cheng; Meng-Hsin Wu; Ling-Hsien Tu; Jerry Chun Chung Chan
Journal:  Chem Sci       Date:  2022-06-22       Impact factor: 9.969
  8 in total

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