Tristan Langlais1,2, Claudio Vergari3, Raphael Pietton4,3, Jean Dubousset3, Wafa Skalli3, Raphael Vialle4. 1. Department for Innovative Therapies in Musculoskeletal Diseases, DHU MAMUTH - Department of Pediatric Orthopaedic, Armand Trousseau Hospital, Université Pierre et Marie Curie Paris 6 - 26 avenue du Dr Arnold Netter, 75571, Paris Cedex 12, France. tristanlanglais@yahoo.fr. 2. Arts et Metiers ParisTech, LBM/Institut de Biomécanique Humaine Georges Charpak, 151 boulevard de l'hôpital, 75013, Paris, France. tristanlanglais@yahoo.fr. 3. Arts et Metiers ParisTech, LBM/Institut de Biomécanique Humaine Georges Charpak, 151 boulevard de l'hôpital, 75013, Paris, France. 4. Department for Innovative Therapies in Musculoskeletal Diseases, DHU MAMUTH - Department of Pediatric Orthopaedic, Armand Trousseau Hospital, Université Pierre et Marie Curie Paris 6 - 26 avenue du Dr Arnold Netter, 75571, Paris Cedex 12, France.
Abstract
OBJECTIVES: In vitro studies showed that annulus fibrosus lose its integrity in idiopathic scoliosis. Shear-wave ultrasound elastography can be used for non-invasive measurement of shear-wave speed (SWS) in vivo in the annulus fibrosus, a parameter related to its mechanical properties. The main aim was to assess SWS in lumbar annulus fibrosus of scoliotic adolescents and compare it to healthy subjects. METHODS: SWS was measured in 180 lumbar IVDs (L3L4, L4L5, L5S1) of 30 healthy adolescents (13 ± 1.9 years old) and 30 adolescent idiopathic scoliosis patients (13 ± 2 years old, Cobb angle: 28.8° ± 10.4°). SWS was compared between the scoliosis and healthy control groups. RESULTS: In healthy subjects, average SWS (all disc levels pooled) was 3.0 ± 0.3 m/s, whereas in scoliotic patients it was significantly higher at 3.5 ± 0.3 m/s (p = 0.0004; Mann-Whitney test). Differences were also significant at all disc levels. No difference was observed between males and females. No correlation was found with age, weight and height. CONCLUSION: Non-invasive shear-wave ultrasound is a novel method of assessment to quantitative alteration of annulus fibrosus. These preliminary results are promising for considering shear-wave elastography as a biomechanical marker for assessment of idiopathic scoliosis. KEY POINTS: • Adolescent idiopathic scoliosis may have an altered lumbar annulus fibrosus. • Shear-wave elastography can quantify lumbar annulus fibrosus mechanical properties. • Shear-wave speed was higher in scoliotic annulus than in healthy subjects. • Elastography showed potential as a biomechanical marker for characterizing disc alteration.
OBJECTIVES: In vitro studies showed that annulus fibrosus lose its integrity in idiopathic scoliosis. Shear-wave ultrasound elastography can be used for non-invasive measurement of shear-wave speed (SWS) in vivo in the annulus fibrosus, a parameter related to its mechanical properties. The main aim was to assess SWS in lumbar annulus fibrosus of scoliotic adolescents and compare it to healthy subjects. METHODS:SWS was measured in 180 lumbar IVDs (L3L4, L4L5, L5S1) of 30 healthy adolescents (13 ± 1.9 years old) and 30 adolescent idiopathic scoliosispatients (13 ± 2 years old, Cobb angle: 28.8° ± 10.4°). SWS was compared between the scoliosis and healthy control groups. RESULTS: In healthy subjects, average SWS (all disc levels pooled) was 3.0 ± 0.3 m/s, whereas in scoliotic patients it was significantly higher at 3.5 ± 0.3 m/s (p = 0.0004; Mann-Whitney test). Differences were also significant at all disc levels. No difference was observed between males and females. No correlation was found with age, weight and height. CONCLUSION: Non-invasive shear-wave ultrasound is a novel method of assessment to quantitative alteration of annulus fibrosus. These preliminary results are promising for considering shear-wave elastography as a biomechanical marker for assessment of idiopathic scoliosis. KEY POINTS: • Adolescent idiopathic scoliosis may have an altered lumbar annulus fibrosus. • Shear-wave elastography can quantify lumbar annulus fibrosus mechanical properties. • Shear-wave speed was higher in scoliotic annulus than in healthy subjects. • Elastography showed potential as a biomechanical marker for characterizing disc alteration.
Authors: Tristan Langlais; Pierre Desprairies; Raphael Pietton; Pierre-Yves Rohan; Jean Dubousset; Judith R Meakin; Peter C Winlove; Raphael Vialle; Wafa Skalli; Claudio Vergari Journal: Biomech Model Mechanobiol Date: 2019-06-20
Authors: Isabel N Tromp; Jasper Foolen; Marina van Doeselaar; Ying Zhang; Danny Chan; Moyo C Kruyt; Laura B Creemers; Rene M Castelein; Keita Ito Journal: J Orthop Res Date: 2020-12-01 Impact factor: 3.102