Raşit Cevizci1, Mehmet Düzlü2, Pınar Göçün Uyar3, Recep Karamert2, Selin Üstün Bezgin4, Hakan Tutar2, Nebil Göksu2, Yıldırım Ahmet Bayazıt1. 1. Department of Otorhinolaryngology, İstanbul Medipol University School of Medicine, İstanbul, Turkey. 2. Department of Otorhinolaryngology, Gazi University School of Medicine, Ankara, Turkey. 3. Department of Pathology, Gazi University School of Medicine, Ankara, Turkey. 4. Department of Otorhinolaryngology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.
Abstract
OBJECTIVE: To assess the histopathological effects of parylene C (PC) (poly-chloro-p-xylylene) in the inner ear. METHODS: Nine adult Dunkin Hartley guinea pigs (500-600 g) were included in the study. PC pieces were inserted into the cochlea in the right ear of the animals (study group). The round windows were punctured in the left ears comprised the control group. After three months, the animals were sacrificed, and the dissected temporal bones were examined under a light microscope. RESULTS: No significant difference was revealed between the study and control groups regarding histopathological findings such as perineural congestion, perineural inflammation, neural fibrosis, number of ganglion cells, edema, and degeneration of ganglion cells (p>0.05). CONCLUSION: PC did not cause any additional histopathologic damage in the cochlea. This finding may be promising regarding the use of PC in cochlear implant electrodes as an alternative to silicon materials in the future.
OBJECTIVE: To assess the histopathological effects of parylene C (PC) (poly-chloro-p-xylylene) in the inner ear. METHODS: Nine adult Dunkin Hartley guinea pigs (500-600 g) were included in the study. PC pieces were inserted into the cochlea in the right ear of the animals (study group). The round windows were punctured in the left ears comprised the control group. After three months, the animals were sacrificed, and the dissected temporal bones were examined under a light microscope. RESULTS: No significant difference was revealed between the study and control groups regarding histopathological findings such as perineural congestion, perineural inflammation, neural fibrosis, number of ganglion cells, edema, and degeneration of ganglion cells (p>0.05). CONCLUSION: PC did not cause any additional histopathologic damage in the cochlea. This finding may be promising regarding the use of PC in cochlear implant electrodes as an alternative to silicon materials in the future.
Authors: Larisa D Kunda; Katrina R Stidham; Michelle M Inserra; Peter S Roland; Daniel Franklin; Joseph B Roberson Journal: Otol Neurotol Date: 2006-12 Impact factor: 2.311
Authors: Tracy Y Chang; Vikramaditya G Yadav; Sarah De Leo; Agustin Mohedas; Bimal Rajalingam; Chia-Ling Chen; Selvapraba Selvarasah; Mehmet R Dokmeci; Ali Khademhosseini Journal: Langmuir Date: 2007-10-04 Impact factor: 3.882
Authors: Paulin N Wahjudi; Jin H Oh; Salam O Salman; Jason A Seabold; Damien C Rodger; Yu-Chong Tai; Mark E Thompson Journal: J Biomed Mater Res A Date: 2009-04 Impact factor: 4.396