Literature DB >> 29367858

Proton tracking for medical imaging and dosimetry.

J T Taylor1, P P Allport1, G L Casse1, N A Smith1, I Tsurin1, N M Allinson2, M Esposito2, A Kacperek3, J Nieto-Camero4, T Price5, C Waltham2.   

Abstract

For many years, silicon micro-strip detectors have been successfully used as tracking detectors for particle and nuclear physics experiments. A new application of this technology is to the field of particle therapy, where radiotherapy is carried out by use of charged particles such as protons or carbon ions. Such a treatment has been shown to have advantages over standard x-ray radiotherapy and as a result of this, many new centres offering particle therapy are currently under construction - including two in the U.K.. The characteristics of a new silicon micro-strip detector based system for this application will be presented. The array uses specifically designed large area sensors in several stations in an x-u-v co-ordinate configuration suitable for very fast proton tracking with minimal ambiguities. The sensors will form a tracker capable of giving information on the path of high energy protons entering and exiting a patient. This will allow proton computed tomography (pCT) to aid the accurate delivery of treatment dose with tuned beam profile and energy. The tracker will also be capable of proton counting and position measurement at the higher fluences and full range of energies used during treatment allowing monitoring of the beam profile and total dose. Results and initial characterisation of sensors will be presented along with details of the proposed readout electronics. Radiation tests and studies with different electronics at the Clatterbridge Cancer Centre and the higher energy proton therapy facility of iThemba LABS in South Africa will also be shown.

Entities:  

Keywords:  Dosimetry concepts and apparatus; Instrumentation for hadron therapy; Particle tracking detectors (Solid-state detectors)

Year:  2015        PMID: 29367858      PMCID: PMC5777586          DOI: 10.1088/1748-0221/10/02/C02015

Source DB:  PubMed          Journal:  J Instrum        ISSN: 1748-0221            Impact factor:   1.415


  8 in total

Review 1.  Particle radiation therapy using proton and heavier ion beams.

Authors:  Daniela Schulz-Ertner; Hirohiko Tsujii
Journal:  J Clin Oncol       Date:  2007-03-10       Impact factor: 44.544

2.  The impact of uncertainties in the CT conversion algorithm when predicting proton beam ranges in patients from dose and PET-activity distributions.

Authors:  Samuel España; Harald Paganetti
Journal:  Phys Med Biol       Date:  2010-11-19       Impact factor: 3.609

3.  Proton radiography as a tool for quality control in proton therapy.

Authors:  U Schneider; E Pedroni
Journal:  Med Phys       Date:  1995-04       Impact factor: 4.071

4.  The 62 MeV proton beam for the treatment of ocular melanoma at Clatterbridge.

Authors:  D E Bonnett; A Kacperek; M A Sheen; R Goodall; T E Saxton
Journal:  Br J Radiol       Date:  1993-10       Impact factor: 3.039

5.  The precision of proton range calculations in proton radiotherapy treatment planning: experimental verification of the relation between CT-HU and proton stopping power.

Authors:  B Schaffner; E Pedroni
Journal:  Phys Med Biol       Date:  1998-06       Impact factor: 3.609

6.  On the clinical spatial resolution achievable with protons and heavier charged particle radiotherapy beams.

Authors:  Pedro Andreo
Journal:  Phys Med Biol       Date:  2009-05-13       Impact factor: 3.609

7.  Development of a Head Scanner for Proton CT.

Authors:  H F-W Sadrozinski; R P Johnson; S Macafee; A Plumb; D Steinberg; A Zatserklyaniy; V Bashkirov F Hurley; R Schulte
Journal:  Nucl Instrum Methods Phys Res A       Date:  2012-04-13       Impact factor: 1.455

Review 8.  Range uncertainties in proton therapy and the role of Monte Carlo simulations.

Authors:  Harald Paganetti
Journal:  Phys Med Biol       Date:  2012-05-09       Impact factor: 3.609

  8 in total
  2 in total

1.  CMOS Active Pixel Sensors as energy-range detectors for proton Computed Tomography.

Authors:  M Esposito; T Anaxagoras; P M Evans; S Green; S Manolopoulos; J Nieto-Camero; D J Parker; G Poludniowski; T Price; C Waltham; N M Allinson
Journal:  J Instrum       Date:  2015-06-03       Impact factor: 1.415

2.  PRaVDA: The first solid-state system for proton computed tomography.

Authors:  Michela Esposito; Chris Waltham; Jonathan T Taylor; Sam Manger; Ben Phoenix; Tony Price; Gavin Poludniowski; Stuart Green; Philip M Evans; Philip P Allport; Spyros Manolopulos; Jaime Nieto-Camero; Julyan Symons; Nigel M Allinson
Journal:  Phys Med       Date:  2018-11-09       Impact factor: 2.685

  2 in total

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