Casia Wardzala1, Charles Murchison2, Jennifer M Loftis3,4, Katie J Schenning5, Nora Mattek2, Randall Woltjer6, Jeff Kaye2,7, Joseph F Quinn2,7, Clare J Wilhelm8,9. 1. Department of Bioengineering, Oregon State University, Corvallis, OR, USA. 2. Department of Neurology, Oregon Health & Science University, Portland, OR, USA. 3. Research & Development Service, VA Portland Health Care System, 3710 SW US Veterans Hospital Rd. (R&D 17), Portland, OR, 97239, USA. 4. Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA. 5. Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA. 6. Department of Pathology, Oregon Health & Science University, Portland, OR, USA. 7. Department of Neurology, VA Portland Health Care System, Portland, OR, USA. 8. Research & Development Service, VA Portland Health Care System, 3710 SW US Veterans Hospital Rd. (R&D 17), Portland, OR, 97239, USA. wilhelmc@ohsu.edu. 9. Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA. wilhelmc@ohsu.edu.
Abstract
RATIONALE: The beneficial effects of moderate alcohol may differ in aging men versus women. OBJECTIVES: Cognitive and functional decline and neuropathology were investigated in a cohort of aging men and women with diverse alcohol histories. METHODS: Non-demented (Clinical Dementia Rating (CDR) of ≤ 0.5 and a Mini-Mental State Examination (MMSE) score of > 24), autonomously living participants were tracked in longitudinal aging studies to examine self-report and objective tests of rates of decline in a cohort (n = 486) of octogenarians. Neurofibrillary tangles (NFTs; Braak stage) and neuritic plaques (NPs) were staged at autopsy in a subset of participants (n = 149) using current standard neuropathologic diagnostic criteria. RESULTS: Moderate drinking men had an attenuated rate of decline compared to rare/never drinkers and women on the MMSE and CDR sum of boxes. In contrast, moderate drinking women had a reduced rate of decline only in the Logical Memory Delayed Recall Test (LMDR) compared to rare/never drinkers and men. Moderate alcohol consumption was associated with a reduction in the incidence of advanced (stages 5-6) Braak NFT stage in men (p < 0.05), with no effect in women. CONCLUSIONS: In this cohort, men experienced a broader range of beneficial effects associated with alcohol. Alcohol's effects may differ in men and women in important ways that suggest a narrower beneficial window.
RATIONALE: The beneficial effects of moderate alcohol may differ in aging men versus women. OBJECTIVES: Cognitive and functional decline and neuropathology were investigated in a cohort of aging men and women with diverse alcohol histories. METHODS:Non-demented (Clinical Dementia Rating (CDR) of ≤ 0.5 and a Mini-Mental State Examination (MMSE) score of > 24), autonomously living participants were tracked in longitudinal aging studies to examine self-report and objective tests of rates of decline in a cohort (n = 486) of octogenarians. Neurofibrillary tangles (NFTs; Braak stage) and neuritic plaques (NPs) were staged at autopsy in a subset of participants (n = 149) using current standard neuropathologic diagnostic criteria. RESULTS: Moderate drinking men had an attenuated rate of decline compared to rare/never drinkers and women on the MMSE and CDR sum of boxes. In contrast, moderate drinking women had a reduced rate of decline only in the Logical Memory Delayed Recall Test (LMDR) compared to rare/never drinkers and men. Moderate alcohol consumption was associated with a reduction in the incidence of advanced (stages 5-6) Braak NFT stage in men (p < 0.05), with no effect in women. CONCLUSIONS: In this cohort, men experienced a broader range of beneficial effects associated with alcohol. Alcohol's effects may differ in men and women in important ways that suggest a narrower beneficial window.
Entities:
Keywords:
Alcohol; Alzheimer’s disease; Cognitive aging; Dementia; Neuropathology; Sex differences
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