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Literature DB >> 21920438

Brain aging, Alzheimer's disease, and mitochondria.

Abstract

The relationship between brain aging and Alzheimer's disease (AD) is contentious. One view holds AD results when brain aging surpasses a threshold. The other view postulates AD is not a consequence of brain aging. This review discusses this conundrum from the perspective of different investigative lines that have tried to address it, as well as from the perspective of the mitochondrion, an organelle that appears to play a role in both AD and brain aging. Specific issues addressed include the question of whether AD and brain aging should be conceptually lumped or split, the extent to which AD and brain aging potentially share common molecular mechanisms, whether beta amyloid should be primarily considered a marker of AD or simply brain aging, and the definition of AD itself. Copyright Â

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Amyloid beta-Peptides

Year: 2011 PMID： 21920438 PMCID： PMC3210037 DOI： 10.1016/j.bbadis.2011.08.012

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

146 in total

Review 1. Abnormalities of mitochondrial enzymes in Alzheimer disease.

Authors: G E Gibson; K F Sheu; J P Blass
Journal: J Neural Transm (Vienna) Date: 1998 Impact factor: 3.575

2. The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells.

Authors: M T Webster; B R Pearce; D M Bowen; P T Francis
Journal: J Neural Transm (Vienna) Date: 1998 Impact factor: 3.575

Review 3. Aging and mitochondria.

Authors: M N Gadaleta; A Cormio; V Pesce; A M Lezza; P Cantatore
Journal: Biochimie Date: 1998-10 Impact factor: 4.079

Brain aging, Alzheimer's disease, and mitochondria.

Review 1. Abnormalities of mitochondrial enzymes in Alzheimer disease.

2. The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells.

Review 3. Aging and mitochondria.

4. Prevalence, incidence and duration of Braak's stages in the general population: can we know?

Review 5. Genetic and functional changes in mitochondria associated with aging.

6. Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells.

7. Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients.

8. Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging.

Review 9. History of dementia and dementia in history: an overview.

10. Secondary inhibition of 2-ketoglutarate dehydrogenase complex by MPTP.

Review 1. Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes.

2. A novel bi-level meta-analysis approach: applied to biological pathway analysis.

Review 3. Mitochondrial function in ageing: coordination with signalling and transcriptional pathways.

Review 4. The Proteasome and Oxidative Stress in Alzheimer's Disease.

Review 5. Estrogen: a master regulator of bioenergetic systems in the brain and body.

Review 6. The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives.

Review 7. Mitochondrial dysfunction and NAD(+) metabolism alterations in the pathophysiology of acute brain injury.

8. Human platelets as a platform to monitor metabolic biomarkers using stable isotopes and LC-MS.

Review 9. Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer's Disease.

Review 10. Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention.