Jordan P Lewis1, Astrid M Suchy-Dicey2,3, Carolyn Noonan2,3, Valarie Blue Bird Jernigan4, Jason G Umans5,6, Kimiko Domoto-Reilly7, Dedra S Buchwald2,3, Spero M Manson8. 1. WWAMI School of Medical Education, College of Health, 3291University of Alaska Anchorage, Anchorage, AK, USA. 2. Institute for Research and Education to Advance Community Health, 6760Washington State University, Seattle, WA, USA. 3. Elson S Floyd College of Medicine, 445950Washington State University, Seattle, WA, USA. 4. College of Public Health, 33264Oklahoma State University Center for Health Sciences, Tulsa, OK, USA. 5. 121577MedStar Health Research Institute, Hyattsville, MD, USA. 6. 553614Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC, USA. 7. Department of Neurology, 312772University of Washington, Seattle, WA, USA. 8. Centers for American Indian and Alaska Native Health, 129263University of Colorado Anschutz Medical Campus, Auraro, CO, USA.
Abstract
Objectives: American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). Methods: We used linear and Poisson regression to examine the association of self-reported binge drinking with VBI, measured via magnetic resonance imaging (MRI), in 817 older AIs who participated in the Strong Heart and Cerebrovascular Disease and Its Consequences in American Indians studies. Results: Any binge drinking at multiple time-points was associated with increased sulcal (β = 0.360, 95% CI [0.079, 0.641]) and ventricle dilatation (β = 0.512, 95% CI [0.174, 0.850]) compared to no binge drinking. Discussion: These observed associations are consistent with previous findings. Identifying how binge drinking may contribute to VBI in older AIs may suggest modifiable health behaviors for neurological risk reduction and disease prevention.
Objectives: American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). Methods: We used linear and Poisson regression to examine the association of self-reported binge drinking with VBI, measured via magnetic resonance imaging (MRI), in 817 older AIs who participated in the Strong Heart and Cerebrovascular Disease and Its Consequences in American Indians studies. Results: Any binge drinking at multiple time-points was associated with increased sulcal (β = 0.360, 95% CI [0.079, 0.641]) and ventricle dilatation (β = 0.512, 95% CI [0.174, 0.850]) compared to no binge drinking. Discussion: These observed associations are consistent with previous findings. Identifying how binge drinking may contribute to VBI in older AIs may suggest modifiable health behaviors for neurological risk reduction and disease prevention.
Entities:
Keywords:
American Indian; binge drinking; older adults
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