Literature DB >> 2909659

Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.

L M Sollid1, G Markussen, J Ek, H Gjerde, F Vartdal, E Thorsby.   

Abstract

Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.

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Year:  1989        PMID： 2909659      PMCID： PMC2189170          DOI： 10.1084/jem.169.1.345

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  17 in total

1.  Recombination between DQ alpha and DQ beta genes generates human histocompatibility leukocyte antigen class II haplotype diversity.

Authors:  Q L Song; P K Gregersen; R W Karr; J Silver
Journal:  J Immunol       Date:  1987-11-01       Impact factor: 5.422

2.  A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules.

Authors:  J H Brown; T Jardetzky; M A Saper; B Samraoui; P J Bjorkman; D C Wiley
Journal:  Nature       Date:  1988-04-28       Impact factor: 49.962

3.  HLA-DQw3.1 and DQw3.2 associated exon polymorphisms detected by oligonucleotide probes.

Authors:  G Markussen; K S Rønningen; G Paulsen; G Gaudernack; L M Sollid; E Thorsby
Journal:  Tissue Antigens       Date:  1988-04

4.  HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.

Authors:  J A Todd; J I Bell; H O McDevitt
Journal:  Nature       Date:  1987 Oct 15-21       Impact factor: 49.962

5.  Evidence that celiac disease is primarily associated with a DC locus allelic specificity.

Authors:  R Tosi; D Vismara; N Tanigaki; G B Ferrara; F Cicimarra; W Buffolano; D Follo; S Auricchio
Journal:  Clin Immunol Immunopathol       Date:  1983-09

6.  HLA-DR phenotypes in Spanish coeliac children: their contribution to the understanding of the genetics of the disease.

Authors:  M L Mearin; I Biemond; A S Peña; I Polanco; C Vazquez; G T Schreuder; R R de Vries; J J van Rood
Journal:  Gut       Date:  1983-06       Impact factor: 23.059

7.  DR and non-DR Ia allotypes are associated with susceptibility to coeliac disease.

Authors:  G R Corazza; P Tabacchi; M Frisoni; C Prati; G Gasbarrini
Journal:  Gut       Date:  1985-11       Impact factor: 23.059

8.  Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta.

Authors:  J M Boss; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

9.  Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains.

Authors:  L Schenning; D Larhammar; P Bill; K Wiman; A K Jonsson; L Rask; P A Peterson
Journal:  EMBO J       Date:  1984-02       Impact factor: 11.598

10.  Multiple discrete encephalitogenic epitopes of the autoantigen myelin basic protein include a determinant for I-E class II-restricted T cells.

Authors:  S S Zamvil; D J Mitchell; M B Powell; K Sakai; J B Rothbard; L Steinman
Journal:  J Exp Med       Date:  1988-09-01       Impact factor: 14.307
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  196 in total

1.  Serological markers and HLA-DQ2 haplotype among first-degree relatives of celiac patients. Catalonian Coeliac Disease Study Group.

Authors:  C Farré; P Humbert; P Vilar; V Varea; X Aldeguer; J Carnicer; M Carballo; M A Gassull
Journal:  Dig Dis Sci       Date:  1999-11       Impact factor: 3.199

2.  Use of closely related affected individuals for the genetic study of complex diseases in founder populations.

Authors:  C Bourgain; E Génin; P Holopainen; K Mustalahti; M Mäki; J Partanen; F Clerget-Darpoux
Journal:  Am J Hum Genet       Date:  2000-11-30       Impact factor: 11.025

Review 3.  Pathogenesis of coeliac disease: implications for treatment.

Authors:  J S Fraser; P J Ciclitira
Journal:  World J Gastroenterol       Date:  2001-12       Impact factor: 5.742

4.  A possible association between basic amino acids of position 13 of DRB1 chains and autoimmune hepatitis.

Authors:  M Ota; T Seki; K Kiyosawa; S Furuta; K Hino; T Kondo; H Fukushima; K Tsuji; H Inoko
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

Review 5.  HLA-linked susceptibility and resistance to Takayasu arteritis.

Authors:  R P Dong; A Kimura; F Numano; Y Nishimura; T Sasazuki
Journal:  Heart Vessels Suppl       Date:  1992

6.  The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses.

Authors:  Willemijn Vader; Dariusz Stepniak; Yvonne Kooy; Luisa Mearin; Allan Thompson; Jon J van Rood; Liesbeth Spaenij; Frits Koning
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-06       Impact factor: 11.205

7.  A novel and sensitive method for the detection of T cell stimulatory epitopes of alpha/beta- and gamma-gliadin.

Authors:  E H A Spaenij-Dekking; E M C Kooy-Winkelaar; W F Nieuwenhuizen; J W Drijfhout; F Koning
Journal:  Gut       Date:  2004-09       Impact factor: 23.059

8.  Increase of lymphocytes bearing the gamma/delta T cell receptor in the jejunum of patients with dermatitis herpetiformis.

Authors:  E Savilahti; T Reunala; M Mäki
Journal:  Gut       Date:  1992-02       Impact factor: 23.059

9.  Analysis of complex genetic systems by ARMS-SSCP: application to HLA genotyping.

Authors:  Y M Lo; P Patel; W Z Mehal; K A Fleming; J I Bell; J S Wainscoat
Journal:  Nucleic Acids Res       Date:  1992-03-11       Impact factor: 16.971

10.  Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis.

Authors:  Marie-Claude Babron; Hervé Perdry; Adam E Handel; Sreeram V Ramagopalan; Vincent Damotte; Bertrand Fontaine; Bertram Müller-Myhsok; George C Ebers; Françoise Clerget-Darpoux
Journal:  Eur J Hum Genet       Date:  2011-11-16       Impact factor: 4.246
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