Literature DB >> 3309680

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.

J A Todd1, J I Bell, H O McDevitt.   

Abstract

Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.

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Year:  1987        PMID： 3309680     DOI： 10.1038/329599a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  476 in total

Review 1.  Immune mechanisms that regulate susceptibility to autoimmune type I diabetes.

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Review 2.  DR, DQ, and you: MHC alleles and autoimmunity.

Authors:  G Sønderstrup; H O McDevitt
Journal:  J Clin Invest       Date:  2001-04       Impact factor: 14.808

3.  The HLA component of type I diabetes.

Authors:  F Clerget-Darpoux
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Review 4.  Early induction of type 1 diabetes.

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Journal:  Clin Exp Immunol       Date:  2001-11       Impact factor: 4.330

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6.  Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.

Authors:  N J Cox; B Wapelhorst; V A Morrison; L Johnson; L Pinchuk; R S Spielman; J A Todd; P Concannon
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7.  Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition.

Authors:  Anish Suri; James J Walters; Osami Kanagawa; Michael L Gross; Emil R Unanue
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8.  Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.

Authors:  S D Patel; A P Cope; M Congia; T T Chen; E Kim; L Fugger; D Wherrett; G Sonderstrup-McDevitt
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

9.  Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclonal antibodies: transfer of protection by splenic T cells.

Authors:  C Boitard; A Bendelac; M F Richard; C Carnaud; J F Bach
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

Review 10.  Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime".

Authors:  Sally C Kent; Stuart I Mannering; Aaron W Michels; Jenny Aurielle B Babon
Journal:  Curr Diab Rep       Date:  2017-09-02       Impact factor: 4.810
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