Juliana Larocca de Geus1, Letícia Maíra Wambier2, Marcelo Carlos Bortoluzzi3, Alessandro D Loguercio2, Stella Kossatz2, Alessandra Reis4,5. 1. Department of Dentistry, School of Dentistry, Paulo Picanço Faculty, Fortaleza, CE, Brazil. 2. Department of Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil. 3. Department of Stomatology, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil. 4. Department of Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil. reis_ale@hotmail.com. 5. Department of Dentistry, State University of Ponta Grossa, Carlos Cavalcanti street, 4748, Block M., 84030-900, Ponta Grossa, Paraná, Brazil. reis_ale@hotmail.com.
Abstract
OBJECTIVES: A systematic review of clinical studies to evaluate the frequency of micronuclei in the oral mucosa of smokers and non-smokers in adult patients was performed. MATERIALS AND METHODS: A comprehensive search was carried out on MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO, and Cochrane Library and SIGLE without restrictions. Dissertations and thesis were searched using the ProQuest Dissertations and Periodicos Capes Thesis Databases. We included only cross-sectional clinical trials that compared the frequency of micronuclei in the oral mucosa of smokers and non-smokers in adult patients. DATA: After the removal of duplicates, 1338 articles were identified. After title and abstract screening, 35 studies remained. Eighteen studies were further excluded, whereas 17 studies remained for qualitative analysis and 16 for the meta-analysis of the primary and secondary outcomes. A significant difference in the frequency of micronuclei in smokers when compared to non-smokers was observed in the present study. CONCLUSIONS: Despite the high variation in the methodology of the assessed studies, this study showed a higher frequency of micronuclei in exfoliated cells of smokers compared to non-smokers. CLINICAL SIGNIFICANCE: The use of tobacco is associated with cytotoxic and genotoxic effects because a higher frequency of micronuclei in exfoliated cells of smokers was observed.
OBJECTIVES: A systematic review of clinical studies to evaluate the frequency of micronuclei in the oral mucosa of smokers and non-smokers in adult patients was performed. MATERIALS AND METHODS: A comprehensive search was carried out on MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO, and Cochrane Library and SIGLE without restrictions. Dissertations and thesis were searched using the ProQuest Dissertations and Periodicos Capes Thesis Databases. We included only cross-sectional clinical trials that compared the frequency of micronuclei in the oral mucosa of smokers and non-smokers in adult patients. DATA: After the removal of duplicates, 1338 articles were identified. After title and abstract screening, 35 studies remained. Eighteen studies were further excluded, whereas 17 studies remained for qualitative analysis and 16 for the meta-analysis of the primary and secondary outcomes. A significant difference in the frequency of micronuclei in smokers when compared to non-smokers was observed in the present study. CONCLUSIONS: Despite the high variation in the methodology of the assessed studies, this study showed a higher frequency of micronuclei in exfoliated cells of smokers compared to non-smokers. CLINICAL SIGNIFICANCE: The use of tobacco is associated with cytotoxic and genotoxic effects because a higher frequency of micronuclei in exfoliated cells of smokers was observed.
Entities:
Keywords:
Meta-analysis; Micronucleus tests; Systematic review; Tobacco use
Authors: Juliana Larocca de Geus; Luiza Foltran de Azevedo Koch; Cibele Kintopp; Paula Porto Spada; Samantha Pugsley Baratto; Allan Fernando Giovanini; Eduardo Pizzatto; Letícia Maíra Wambier Journal: Int J Health Sci (Qassim) Date: 2021 Jan-Feb
Authors: Anca Maria Pop; Raluca Coroș; Alexandra Mihaela Stoica; Monica Monea Journal: Int J Environ Res Public Health Date: 2021-12-16 Impact factor: 3.390