Alessia Gimelli1, Riccardo Liga2, Serena Magro1,3, Salvatore Novo3, Roberto Pedrinelli4, Anna Sonia Petronio4, Paolo Marzullo1,5, Alessia Pepe1. 1. Fondazione Toscana/CNR G. Monasterio, Via Moruzzi, 1, 56124, Pisa, Italy. 2. Dipartimento di Patologia Chirurgica, Molecolare e dell'Area Critica, Università di Pisa, Pisa, Italy. riccardo.liga@gmail.com. 3. Department of Cardiology, University of Palermo, Palermo, Italy. 4. Dipartimento di Patologia Chirurgica, Molecolare e dell'Area Critica, Università di Pisa, Pisa, Italy. 5. Institute of Clinical Physiology, CNR, Pisa, Italy.
Abstract
BACKGROUND: Single-photon emission computed tomography has shown relevant limitations in the quantification of left ventricular (LV) mass. We sought to compare the estimates of LV mass on Cadmium-Zinc-Telluride (CZT) myocardial perfusion imaging (MPI) as compared to cardiac magnetic resonance (CMR). METHODS AND RESULTS: Twenty-five patients underwent MPI on a CZT camera and CMR on a 1.5 T scanner within 12 ± 3 weeks. LV mass was quantified on CZT images using two softwares: 4D-MSPECT (4DM) and Emory Cardiac Toolbox (ECTb). LV mass by CMR was quantified using MASS software (Medis, Leiden, The Netherlands). LV mass values obtained with 4DM and ECTb were highly reproducible [intraclass correlation coefficients .98 (95% CI .97-.99), and .98 (95% CI 0.97-.99), respectively]. The mean LVM mass values were 151 ± 44 g on CMR, 151 ± 43 g with 4DM (P = NS vs CMR), and 157 ± 42 g with ECTb (P < .001 vs CMR; P = .007 vs 4DM) CZT images. There was an excellent correlation between LV mass values between CMR and both 4DM (R2 = .95; P < .001) and ECTb (R2 = .98; P < .001) with narrow limits of agreement (- 13.6% to + 13.4% for 4DM, and - 5.6% to + 14.1% for ECTb). CONCLUSIONS: The evaluation of LV mass is feasible on CZT images, showing excellent agreement with CMR.
BACKGROUND: Single-photon emission computed tomography has shown relevant limitations in the quantification of left ventricular (LV) mass. We sought to compare the estimates of LV mass on Cadmium-Zinc-Telluride (CZT) myocardial perfusion imaging (MPI) as compared to cardiac magnetic resonance (CMR). METHODS AND RESULTS: Twenty-five patients underwent MPI on a CZT camera and CMR on a 1.5 T scanner within 12 ± 3 weeks. LV mass was quantified on CZT images using two softwares: 4D-MSPECT (4DM) and Emory Cardiac Toolbox (ECTb). LV mass by CMR was quantified using MASS software (Medis, Leiden, The Netherlands). LV mass values obtained with 4DM and ECTb were highly reproducible [intraclass correlation coefficients .98 (95% CI .97-.99), and .98 (95% CI 0.97-.99), respectively]. The mean LVM mass values were 151 ± 44 g on CMR, 151 ± 43 g with 4DM (P = NS vs CMR), and 157 ± 42 g with ECTb (P < .001 vs CMR; P = .007 vs 4DM) CZT images. There was an excellent correlation between LV mass values between CMR and both 4DM (R2 = .95; P < .001) and ECTb (R2 = .98; P < .001) with narrow limits of agreement (- 13.6% to + 13.4% for 4DM, and - 5.6% to + 14.1% for ECTb). CONCLUSIONS: The evaluation of LV mass is feasible on CZT images, showing excellent agreement with CMR.
Entities:
Keywords:
Cadmium-Zinc-Telluride; SPECT; cardiac magnetic resonance; left ventricular mass
Authors: Michael L Chuang; Philimon Gona; Gilion L T F Hautvast; Carol J Salton; Susan J Blease; Susan B Yeon; Marcel Breeuwer; Christopher J O'Donnell; Warren J Manning Journal: JACC Cardiovasc Imaging Date: 2012-11
Authors: A-C Pouleur; J-B le Polain de Waroux; A Pasquet; B L Gerber; O Gérard; P Allain; J-L J Vanoverschelde Journal: Heart Date: 2007-11-01 Impact factor: 5.994