Giovanni Donato Aquaro1, Giovanni Camastra2, Lorenzo Monti3, Massimo Lombardi4, Alessia Pepe1, Silvia Castelletti5, Viviana Maestrini6, Giancarlo Todiere1, Piergiorgio Masci7, Gabriella di Giovine3, Andrea Barison1, Santo Dellegrottaglie8, Martina Perazzolo Marra9, Gianluca Pontone10, Gianluca Di Bella11. 1. Gabriele Monasterio Foundation-CNR Region Toscana, Pisa, Italy. 2. U.O Cardiologia, Ospedale Vannini, Roma, Italy. 3. U.O Radiologia Diagnostica, Humanitas Hospital, Rozzano (MI), Italy. 4. Multimodality Cardiac Imaging Section, I.R.C.C.S. Policlinico San Donato, San Donato Milanese (MI), Italy. 5. Istituto Auxologico Italiano, Milano, Italy. 6. Università La Sapienza, Roma, Italy. 7. Centre Hospitalier Universitaire Vadois (CHUV) - University Hospital Lausanne, Lausanne, Switzerland. 8. Laboratorio di RM Cardiovascolare Divisione di Cardiologia Clinica Villa dei Fiori, Acerra, Italy. 9. U.O. Cardiologia, Azienda Ospedaliera Universitaria Padova, Italy. 10. U.O. Cardiologia, Centro Cardiologico Monzino, Milano, Italy. 11. U.O. Cardiologia, Università di Messina, Italy.
Abstract
PURPOSE: To define reference values of cardiac volumes, dimensions, and new morpho-functional parameters normalized for age, gender, and body surface area by cine-bSSFP (balanced steady-state free-precession) magnetic resonance (MR). MATERIALS AND METHODS: We enrolled 308 healthy subjects subdivided by gender and by six age classes: class I, >15-20 years; class II, >20-30 years; class III, >30-40 years; class IV, >40-50 years; class V, >50-60 years; and class VI >60 years. Dimensional, volumetric and morpho-functional parameters of the left (LV) and right (RV) ventricles were measured using cine-bSSFP MRI at 1.5T. RESULTS: The LV and RV end-diastolic volume indexes (EDVi) were inversely related to age (P < 0.0001 r = -0.34 and P < 0.0001 r = -0.37, respectively). In addition, the LV mass index decreased with age (P = 0.0004, r = -0.21). The LV longitudinal shortening was not significantly different among groups: ≥15% in all populations (95% confidence interval [CI]: 16-31). The sphericity index measured in end-diastole was higher in females than in males (P < 0.03): the upper limit was 40% for males and 42% for females. The normality cutoff of LV global function index was ≥33% in males and ≥35% in females. The end-diastolic volume (EDV) of RV and LV was balanced (RV/LV ratio 0.85-1.15) without differences in the population. The LV EDV/mass was 1.0-1.8 in males and 1.0-2.1 in females. CONCLUSION: This study provides potential age- and gender-specific reference. LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:1055-1067.
PURPOSE: To define reference values of cardiac volumes, dimensions, and new morpho-functional parameters normalized for age, gender, and body surface area by cine-bSSFP (balanced steady-state free-precession) magnetic resonance (MR). MATERIALS AND METHODS: We enrolled 308 healthy subjects subdivided by gender and by six age classes: class I, >15-20 years; class II, >20-30 years; class III, >30-40 years; class IV, >40-50 years; class V, >50-60 years; and class VI >60 years. Dimensional, volumetric and morpho-functional parameters of the left (LV) and right (RV) ventricles were measured using cine-bSSFP MRI at 1.5T. RESULTS: The LV and RV end-diastolic volume indexes (EDVi) were inversely related to age (P < 0.0001 r = -0.34 and P < 0.0001 r = -0.37, respectively). In addition, the LV mass index decreased with age (P = 0.0004, r = -0.21). The LV longitudinal shortening was not significantly different among groups: ≥15% in all populations (95% confidence interval [CI]: 16-31). The sphericity index measured in end-diastole was higher in females than in males (P < 0.03): the upper limit was 40% for males and 42% for females. The normality cutoff of LV global function index was ≥33% in males and ≥35% in females. The end-diastolic volume (EDV) of RV and LV was balanced (RV/LV ratio 0.85-1.15) without differences in the population. The LV EDV/mass was 1.0-1.8 in males and 1.0-2.1 in females. CONCLUSION: This study provides potential age- and gender-specific reference. LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:1055-1067.
Keywords:
RV/LV EDV ratio; cardiac magnetic resonance imaging; left ventricular global function index; longitudinal shortening; reference values; sphericity index
Authors: Carlo De Innocentiis; Fabrizio Ricci; Mohammed Y Khanji; Nay Aung; Claudio Tana; Elvira Verrengia; Steffen E Petersen; Sabina Gallina Journal: Sports Med Date: 2018-11 Impact factor: 11.136