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Literature DB >> 29033456

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation.

Abstract

The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying enzymes that have a central role in epigenetic gene regulation. Recent studies have shown that the functions of the canonical DNMT enzymes - DNMT1, DNMT3A and DNMT3B - go beyond their traditional roles of establishing and maintaining DNA methylation patterns. This Review analyses how molecular interactions and changes in gene copy numbers modulate the activity of DNMTs in diverse gene regulatory functions, including transcriptional silencing, transcriptional activation and post-transcriptional regulation by DNMT2-dependent tRNA methylation. This mechanistic diversity enables the DNMT family to function as a versatile toolkit for epigenetic regulation.

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Year: 2017 PMID： 29033456 DOI： 10.1038/nrg.2017.80

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

156 in total

1. MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome.

Authors: Lin Chen; Kaifu Chen; Laura A Lavery; Steven Andrew Baker; Chad A Shaw; Wei Li; Huda Y Zoghbi
Journal: Proc Natl Acad Sci U S A Date: 2015-04-13 Impact factor: 11.205

Review 2. Two substrates are better than one: dual specificities for Dnmt2 methyltransferases.

Authors: Albert Jeltsch; Wolfgang Nellen; Frank Lyko
Journal: Trends Biochem Sci Date: 2006-05-06 Impact factor: 13.807

3. The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.

Authors: David A Russler-Germain; David H Spencer; Margaret A Young; Tamara L Lamprecht; Christopher A Miller; Robert Fulton; Matthew R Meyer; Petra Erdmann-Gilmore; R Reid Townsend; Richard K Wilson; Timothy J Ley
Journal: Cancer Cell Date: 2014-03-20 Impact factor: 31.743

4. Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

Authors: B H Ramsahoye; D Biniszkiewicz; F Lyko; V Clark; A P Bird; R Jaenisch
Journal: Proc Natl Acad Sci U S A Date: 2000-05-09 Impact factor: 11.205

5. DNMT3A mutations in acute myeloid leukemia.

Authors: Timothy J Ley; Li Ding; Matthew J Walter; Michael D McLellan; Tamara Lamprecht; David E Larson; Cyriac Kandoth; Jacqueline E Payton; Jack Baty; John Welch; Christopher C Harris; Cheryl F Lichti; R Reid Townsend; Robert S Fulton; David J Dooling; Daniel C Koboldt; Heather Schmidt; Qunyuan Zhang; John R Osborne; Ling Lin; Michelle O'Laughlin; Joshua F McMichael; Kim D Delehaunty; Sean D McGrath; Lucinda A Fulton; Vincent J Magrini; Tammi L Vickery; Jasreet Hundal; Lisa L Cook; Joshua J Conyers; Gary W Swift; Jerry P Reed; Patricia A Alldredge; Todd Wylie; Jason Walker; Joelle Kalicki; Mark A Watson; Sharon Heath; William D Shannon; Nobish Varghese; Rakesh Nagarajan; Peter Westervelt; Michael H Tomasson; Daniel C Link; Timothy A Graubert; John F DiPersio; Elaine R Mardis; Richard K Wilson
Journal: N Engl J Med Date: 2010-11-10 Impact factor: 91.245

6. Cellular differentiation, cytidine analogs and DNA methylation.

Authors: P A Jones; S M Taylor
Journal: Cell Date: 1980-05 Impact factor: 41.582

Review 7. DNA methylation profiling in the clinic: applications and challenges.

Authors: Holger Heyn; Manel Esteller
Journal: Nat Rev Genet Date: 2012-09-04 Impact factor: 53.242

8. Repurposing the CRISPR-Cas9 system for targeted DNA methylation.

Authors: Aleksandar Vojta; Paula Dobrinić; Vanja Tadić; Luka Bočkor; Petra Korać; Boris Julg; Marija Klasić; Vlatka Zoldoš
Journal: Nucleic Acids Res Date: 2016-03-11 Impact factor: 16.971

9. Role of Tet proteins in enhancer activity and telomere elongation.

Authors: Falong Lu; Yuting Liu; Lan Jiang; Shinpei Yamaguchi; Yi Zhang
Journal: Genes Dev Date: 2014-09-15 Impact factor: 11.361

10. Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences.

Authors: Raghuvaran Shanmugam; Jacob Fierer; Steffen Kaiser; Mark Helm; Tomasz P Jurkowski; Albert Jeltsch
Journal: Cell Discov Date: 2015-06-09 Impact factor: 10.849

307 in total

Review 1. Transcriptional and Epigenomic Regulation of Adipogenesis.

Authors: Ji-Eun Lee; Hannah Schmidt; Binbin Lai; Kai Ge
Journal: Mol Cell Biol Date: 2019-05-14 Impact factor: 4.272

Review 2. SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation.

Authors: Kouminin Kanwore; Xiao-Xiao Guo; Ayanlaja Abiola Abdulrahman; Piniel Alphayo Kambey; Iqra Nadeem; Dianshuai Gao
Journal: Mol Neurobiol Date: 2021-01-22 Impact factor: 5.590

Review 3. Epigenetic Mechanisms and Hypertension.

Authors: Mingyu Liang
Journal: Hypertension Date: 2018-12 Impact factor: 10.190

4. DNA 5-Methylcytosine-Specific Amplification and Sequencing.

Authors: Chang Liu; Xiaolong Cui; Boxuan Simen Zhao; Pradnya Narkhede; Yawei Gao; Jun Liu; Xiaoyang Dou; Qing Dai; Li-Sheng Zhang; Chuan He
Journal: J Am Chem Soc Date: 2020-02-25 Impact factor: 15.419

Review 5. Epidrugs: targeting epigenetic marks in cancer treatment.

Authors: Cristiana Libardi Miranda Furtado; Maria Claudia Dos Santos Luciano; Renan Da Silva Santos; Gilvan Pessoa Furtado; Manoel Odorico Moraes; Claudia Pessoa
Journal: Epigenetics Date: 2019-07-13 Impact factor: 4.528

Review 6. Promoter DNA hypermethylation - Implications for Alzheimer's disease.

Authors: Yiyuan Liu; Minghui Wang; Edoardo M Marcora; Bin Zhang; Alison M Goate
Journal: Neurosci Lett Date: 2019-07-24 Impact factor: 3.046

7. Gaussian mixture model-based unsupervised nucleotide modification number detection using nanopore-sequencing readouts.

Authors: Hongxu Ding; Andrew D Bailey; Miten Jain; Hugh Olsen; Benedict Paten
Journal: Bioinformatics Date: 2020-12-08 Impact factor: 6.937