Literature DB >> 31351091

Promoter DNA hypermethylation - Implications for Alzheimer's disease.

Yiyuan Liu1, Minghui Wang2, Edoardo M Marcora1, Bin Zhang3, Alison M Goate1.   

Abstract

Recent methylome-wide association studies (MWAS) in humans have solidified the concept that aberrant DNA methylation is associated with Alzheimer's disease (AD). We summarize these findings to improve the understanding of mechanisms governing DNA methylation pertinent to transcriptional regulation, with an emphasis of AD-associated promoter DNA hypermethylation, which establishes an epigenetic barrier for transcriptional activation. By considering brain cell type specific expression profiles that have been published only for non-demented individuals, we detail functional activities of selected neuron, microglia, and astrocyte-enriched genes (AGAP2, DUSP6 and GPR37L1, respectively), which are DNA hypermethylated at promoters in AD. We highlight future directions in MWAS including experimental confirmation, functional relevance to AD, cell type-specific temporal characterization, and mechanism investigation.
Copyright © 2019 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; DNA methylation; Promoter DNA hypermethylation

Year:  2019        PMID： 31351091      PMCID： PMC6759378          DOI： 10.1016/j.neulet.2019.134403

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  146 in total

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