Literature DB >> 22945394

DNA methylation profiling in the clinic: applications and challenges.

Holger Heyn1, Manel Esteller.   

Abstract

Knowledge of epigenetic alterations in disease is rapidly increasing owing to the development of genome-wide techniques for their identification. The ever-growing number of genes that show epigenetic alterations in disease emphasizes the crucial role of these epigenetic alterations - particularly DNA methylation - for future diagnosis, prognosis and prediction of response to therapies. This Review focuses on epigenetic profiling, which has started to be of clinical value in cancer and may in the future be extended to other diseases, such as neurological and autoimmune disorders.

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Year:  2012        PMID： 22945394     DOI： 10.1038/nrg3270

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  138 in total

Review 1.  A decade of exploring the cancer epigenome - biological and translational implications.

Authors:  Stephen B Baylin; Peter A Jones
Journal:  Nat Rev Cancer       Date:  2011-09-23       Impact factor: 60.716

2.  A gene hypermethylation profile of human cancer.

Authors:  M Esteller; P G Corn; S B Baylin; J G Herman
Journal:  Cancer Res       Date:  2001-04-15       Impact factor: 12.701

3.  Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.

Authors:  M Esteller; J M Silva; G Dominguez; F Bonilla; X Matias-Guiu; E Lerma; E Bussaglia; J Prat; I C Harkes; E A Repasky; E Gabrielson; M Schutte; S B Baylin; J G Herman
Journal:  J Natl Cancer Inst       Date:  2000-04-05       Impact factor: 13.506

4.  Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2.

Authors:  Hengmi Cui; Patrick Onyango; Sheri Brandenburg; Yiqian Wu; Chih-Lin Hsieh; Andrew P Feinberg
Journal:  Cancer Res       Date:  2002-11-15       Impact factor: 12.701

5.  Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients.

Authors:  S L Rosas; W Koch; M G da Costa Carvalho; L Wu; J Califano; W Westra; J Jen; D Sidransky
Journal:  Cancer Res       Date:  2001-02-01       Impact factor: 12.701

6.  Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

Authors:  M Esteller; S R Hamilton; P C Burger; S B Baylin; J G Herman
Journal:  Cancer Res       Date:  1999-02-15       Impact factor: 12.701

7.  Aberrant methylation in the promoter region of the reduced folate carrier gene is a potential mechanism of resistance to methotrexate in primary central nervous system lymphomas.

Authors:  Andrés J M Ferreri; Stefania Dell'Oro; Daniela Capello; Maurilio Ponzoni; Paolo Iuzzolino; Davide Rossi; Felice Pasini; Achille Ambrosetti; Enrico Orvieto; Fabio Ferrarese; Gianluigi Arrigoni; Marco Foppoli; Michele Reni; Gianluca Gaidano
Journal:  Br J Haematol       Date:  2004-09       Impact factor: 6.998

8.  Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection.

Authors:  Masashi Nakayama; Christina J Bennett; Jessica L Hicks; Jonathan I Epstein; Elizabeth A Platz; William G Nelson; Angelo M De Marzo
Journal:  Am J Pathol       Date:  2003-09       Impact factor: 4.307

9.  Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

Authors:  W H Lee; R A Morton; J I Epstein; J D Brooks; P A Campbell; G S Bova; W S Hsieh; W B Isaacs; W G Nelson
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205

10.  BLUEPRINT to decode the epigenetic signature written in blood.

Authors:  David Adams; Lucia Altucci; Stylianos E Antonarakis; Juan Ballesteros; Stephan Beck; Adrian Bird; Christoph Bock; Bernhard Boehm; Elias Campo; Andrea Caricasole; Fredrik Dahl; Emmanouil T Dermitzakis; Tariq Enver; Manel Esteller; Xavier Estivill; Anne Ferguson-Smith; Jude Fitzgibbon; Paul Flicek; Claudia Giehl; Thomas Graf; Frank Grosveld; Roderic Guigo; Ivo Gut; Kristian Helin; Jonas Jarvius; Ralf Küppers; Hans Lehrach; Thomas Lengauer; Åke Lernmark; David Leslie; Markus Loeffler; Elizabeth Macintyre; Antonello Mai; Joost H A Martens; Saverio Minucci; Willem H Ouwehand; Pier Giuseppe Pelicci; Hèléne Pendeville; Bo Porse; Vardhman Rakyan; Wolf Reik; Martin Schrappe; Dirk Schübeler; Martin Seifert; Reiner Siebert; David Simmons; Nicole Soranzo; Salvatore Spicuglia; Michael Stratton; Hendrik G Stunnenberg; Amos Tanay; David Torrents; Alfonso Valencia; Edo Vellenga; Martin Vingron; Jörn Walter; Spike Willcocks
Journal:  Nat Biotechnol       Date:  2012-03-07       Impact factor: 54.908
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  313 in total

1.  IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus.

Authors:  Ming Zhao; Yin Zhou; Bochen Zhu; Mengjie Wan; Tingting Jiang; Qiqun Tan; Yan Liu; Juqing Jiang; Shuaihantian Luo; Yixin Tan; Haijing Wu; Paul Renauer; Maria Del Mar Ayala Gutiérrez; Maria Jesús Castillo Palma; Rafaela Ortega Castro; Concepción Fernández-Roldán; Enrique Raya; Raquel Faria; Claudia Carvalho; Marta E Alarcón-Riquelme; Zhongyuan Xiang; Jinwei Chen; Fen Li; Guanghui Ling; Hongjun Zhao; Xiangping Liao; Youkun Lin; Amr H Sawalha; Qianjin Lu
Journal:  Ann Rheum Dis       Date:  2016-01-19       Impact factor: 19.103

2.  A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact.

Authors:  A C Queirós; N Villamor; G Clot; A Martinez-Trillos; M Kulis; A Navarro; E M M Penas; S Jayne; A Majid; J Richter; A K Bergmann; J Kolarova; C Royo; N Russiñol; G Castellano; M Pinyol; S Bea; I Salaverria; M López-Guerra; D Colomer; M Aymerich; M Rozman; J Delgado; E Giné; M González-Díaz; X S Puente; R Siebert; M J S Dyer; C López-Otín; C Rozman; E Campo; A López-Guillermo; J I Martín-Subero
Journal:  Leukemia       Date:  2014-08-25       Impact factor: 11.528

3.  Epigenome-wide association study for 28-day survival of acute respiratory distress syndrome.

Authors:  Yichen Guo; Ruyang Zhang; Zhaozhong Zhu; Sipeng Shen; Li Su; David C Christiani
Journal:  Intensive Care Med       Date:  2018-03-06       Impact factor: 17.440

Review 4.  From promises to practical strategies in epigenetic epidemiology.

Authors:  Jonathan Mill; Bastiaan T Heijmans
Journal:  Nat Rev Genet       Date:  2013-07-02       Impact factor: 53.242

5.  Aberrant DNA methylation profile of chronic and transformed classic Philadelphia-negative myeloproliferative neoplasms.

Authors:  Cristina Pérez; Marien Pascual; José Ignacio Martín-Subero; Beatriz Bellosillo; Victor Segura; Eric Delabesse; Sara Álvarez; María José Larrayoz; José Rifón; Juan Cruz Cigudosa; Carles Besses; María José Calasanz; Nicholas C P Cross; Felipe Prósper; Xabier Agirre
Journal:  Haematologica       Date:  2013-05-28       Impact factor: 9.941

Review 6.  DNA methylation and childhood maltreatment: from animal models to human studies.

Authors:  P-E Lutz; G Turecki
Journal:  Neuroscience       Date:  2013-08-08       Impact factor: 3.590

7.  Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA.

Authors:  Andrew H Laszlo; Ian M Derrington; Henry Brinkerhoff; Kyle W Langford; Ian C Nova; Jenny Mae Samson; Joshua J Bartlett; Mikhail Pavlenok; Jens H Gundlach
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-28       Impact factor: 11.205

8.  A suite of DNA methylation markers that can detect most common human cancers.

Authors:  Lukas Vrba; Bernard W Futscher
Journal:  Epigenetics       Date:  2018-02-19       Impact factor: 4.528

9.  Dual epigenetic modifiers for cancer therapy.

Authors:  Edurne San José-Enériz; Obdulia Rabal; Xabier Agirre; Julen Oyarzabal; Felipe Prosper
Journal:  Mol Cell Oncol       Date:  2017-06-20

10.  Characterization and directed evolution of a methyl-binding domain protein for high-sensitivity DNA methylation analysis.

Authors:  Brandon W Heimer; Brooke E Tam; Hadley D Sikes
Journal:  Protein Eng Des Sel       Date:  2015-09-18       Impact factor: 1.650
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