Literature DB >> 28983934

Free dug concentrations in pregnancy: Bound to measure unbound?

Stein Schalkwijk1,2, Rick Greupink2, David Burger1.   

Abstract

Keywords:  albumin; antiretrovirals; pharmacokinetics; pregnancy; protein binding

Mesh:

Substances:

Year:  2017        PMID: 28983934      PMCID: PMC5698572          DOI: 10.1111/bcp.13432

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


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2.  Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based pharmacokinetic modelling.

Authors:  Khaled Abduljalil; Penny Furness; Trevor N Johnson; Amin Rostami-Hodjegan; Hora Soltani
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Review 3.  Monitoring free drug concentrations: challenges.

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4.  Antiretroviral unbound concentration during pregnancy: piece of interest in the puzzle?

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Journal:  J Antimicrob Chemother       Date:  2017-09-01       Impact factor: 5.790

5.  Free and total plasma concentrations of elvitegravir/cobicistat during pregnancy and postpartum: a case report.

Authors:  Catia Marzolini; Laurent Decosterd; Ursula Winterfeld; Frédéric Tissot; Katyuska Francini; Thierry Buclin; Françoise Livio
Journal:  Br J Clin Pharmacol       Date:  2017-05-16       Impact factor: 4.335

Review 6.  Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach.

Authors:  Gail D Anderson
Journal:  Clin Pharmacokinet       Date:  2005       Impact factor: 6.447

7.  Pharmacokinetics of Total and Unbound Etravirine in HIV-1-Infected Pregnant Women.

Authors:  Moti Ramgopal; Olayemi Osiyemi; Carmen Zorrilla; Herta M Crauwels; Robert Ryan; Kimberley Brown; Vera Hillewaert; Bryan Baugh
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8.  Pharmacokinetics of total and unbound darunavir in HIV-1-infected pregnant women.

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1.  Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling.

Authors:  Stein Schalkwijk; Rob Ter Heine; Angela Colbers; Edmund Capparelli; Brookie M Best; Tim R Cressey; Rick Greupink; Frans G M Russel; José Moltó; Mark Mirochnick; Mats O Karlsson; David M Burger
Journal:  J Antimicrob Chemother       Date:  2019-05-01       Impact factor: 5.790

2.  Free dug concentrations in pregnancy: Bound to measure unbound?

Authors:  Stein Schalkwijk; Rick Greupink; David Burger
Journal:  Br J Clin Pharmacol       Date:  2017-10-06       Impact factor: 4.335

Review 3.  An update on the physiologic changes during pregnancy and their impact on drug pharmacokinetics and pharmacogenomics.

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Review 5.  Drug-Drug Interactions with Antiretroviral Drugs in Pregnant Women Living with HIV: Are They Different from Non-Pregnant Individuals?

Authors:  Vera E Bukkems; Angela Colbers; Catia Marzolini; Jose Molto; David M Burger
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6.  Bedaquiline exposure in pregnancy and breastfeeding in women with rifampicin-resistant tuberculosis.

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7.  A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women.

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Review 8.  Pharmacokinetics of HIV-Integrase Inhibitors During Pregnancy: Mechanisms, Clinical Implications and Knowledge Gaps.

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Review 9.  Review article: direct-acting antivirals for the treatment of HCV during pregnancy and lactation - implications for maternal dosing, foetal exposure, and safety for mother and child.

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10.  A population pharmacokinetics analysis assessing the exposure of raltegravir once-daily 1200 mg in pregnant women living with HIV.

Authors:  Vera E Bukkems; Teun M Post; Angela P Colbers; David M Burger; Elin M Svensson
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