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Literature DB >> 28947943

Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates.

Gaia Fumagalli¹, Barbara Stella², Ievgenia Pastushenko³, Francesca Ricci⁴, Michael S Christodoulou¹, Giovanna Damia⁴, Davide Mazza^5,6, Silvia Arpicco², Clelia Giannini¹, Lavinia Morosi⁷, Franco Dosio², Panagiota A Sotiropoulou³, Daniele Passarella¹.

Abstract

The preparation of heteronanoparticles (NPs) with doxorubicin (DOXO) and cyclopamine (CYP) conjugates is presented. Biological evaluation on A431 cell lines confirms the maintenance of the activity of the parental drugs. The in vivo study shows that self-assembled NPs reduce tumor growth and toxicity of chemotherapy.

Entities: Chemical Disease

Keywords: Self-assembled-nanoparticles; cancer; cyclopamine; doxorubicin; drug toxicity

Year: 2017 PMID： 28947943 PMCID： PMC5601370 DOI： 10.1021/acsmedchemlett.7b00262

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

9 in total

1. Mutations in the human homologue of the Drosophila segment polarity gene patched in oral squamous cell carcinoma cell lines.

Authors: E Michimukai; N Kitamura; Y Zhang; H Wang; Y Hiraishi; K Sumi; Y Hayashido; S Toratani; T Okamoto
Journal: In Vitro Cell Dev Biol Anim Date: 2001 Jul-Aug Impact factor: 2.416

Review 2. Natural Products and Cancer Stem Cells.

Authors: Cristina Marucci; Gaia Fumagalli; Francesco Calogero; Alessandra Silvani; Michael S Christodoulou; Nadine Martinet; Daniele Passarella
Journal: Curr Pharm Des Date: 2015 Impact factor: 3.116

3. Multifunctional Nanoparticles Self-Assembled from Small Organic Building Blocks for Biomedicine.

Authors: Pengyao Xing; Yanli Zhao
Journal: Adv Mater Date: 2016-06-06 Impact factor: 30.849

4. Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks.

Authors: Gaia Fumagalli; Michael S Christodoulou; Benedetta Riva; Inigo Revuelta; Cristina Marucci; Veronica Collico; Davide Prosperi; Sergio Riva; Dario Perdicchia; Ivan Bassanini; Aida García-Argáez; Lisa Dalla Via; Daniele Passarella
Journal: Org Biomol Chem Date: 2017-02-01 Impact factor: 3.876

Review 5. Self-assembly drug conjugates for anticancer treatment.

Authors: Gaia Fumagalli; Cristina Marucci; Michael S Christodoulou; Barbara Stella; Franco Dosio; Daniele Passarella
Journal: Drug Discov Today Date: 2016-06-18 Impact factor: 7.851

Review 6. Chemical approaches to targeting drug resistance in cancer stem cells.

Authors: Panagiota A Sotiropoulou; Michael S Christodoulou; Alessandra Silvani; Christel Herold-Mende; Daniele Passarella
Journal: Drug Discov Today Date: 2014-05-10 Impact factor: 7.851

7. New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.

Authors: Stella Borrelli; Michael S Christodoulou; Ilaria Ficarra; Alessandra Silvani; Graziella Cappelletti; Daniele Cartelli; Giovanna Damia; Francesca Ricci; Massimo Zucchetti; Franco Dosio; Daniele Passarella
Journal: Eur J Med Chem Date: 2014-07-27 Impact factor: 6.514

8. Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics.

Authors: José L Arias; L Harivardhan Reddy; Mohammad Othman; Brigitte Gillet; Didier Desmaële; Fatima Zouhiri; Franco Dosio; Ruxandra Gref; Patrick Couvreur
Journal: ACS Nano Date: 2011-01-28 Impact factor: 15.881

9. A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity.

Authors: Andrei Maksimenko; Franco Dosio; Julie Mougin; Annalisa Ferrero; Severine Wack; L Harivardhan Reddy; Andrée-Anne Weyn; Elise Lepeltier; Claudie Bourgaux; Barbara Stella; Luigi Cattel; Patrick Couvreur
Journal: Proc Natl Acad Sci U S A Date: 2014-01-02 Impact factor: 11.205

9 in total

6 in total

1. Heteronanoparticles by Self-Assembly of Ecdysteroid and Doxorubicin Conjugates To Overcome Cancer Resistance.

Authors: Gaia Fumagalli; Giulia Giorgi; Máté Vágvölgyi; Eleonora Colombo; Michael S Christodoulou; Veronica Collico; Davide Prosperi; Franco Dosio; Attila Hunyadi; Monica Montopoli; Mariafrancesca Hyeraci; Alessandra Silvani; Giordano Lesma; Lisa Dalla Via; Daniele Passarella
Journal: ACS Med Chem Lett Date: 2018-04-17 Impact factor: 4.345

2. New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine.

Authors: Eleonora Colombo; Laura Polito; Michele Biocotino; Paola Marzullo; Mariafrancesca Hyeraci; Lisa Dalla Via; Daniele Passarella
Journal: ACS Med Chem Lett Date: 2020-02-28 Impact factor: 4.345

3. Self-assembling Releasable Thiocolchicine-Diphenylbutenylaniline Conjugates.

Authors: Gaia Fumagalli; Laura Polito; Eleonora Colombo; Francesca Foschi; Michael S Christodoulou; Francesco Galeotti; Dario Perdicchia; Ivan Bassanini; Sergio Riva; Pierfausto Seneci; Aída García-Argáez; Lisa Dalla Via; Daniele Passarella
Journal: ACS Med Chem Lett Date: 2019-01-04 Impact factor: 4.345