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Literature DB >> 32435402

New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine.

Eleonora Colombo¹, Laura Polito², Michele Biocotino¹, Paola Marzullo¹, Mariafrancesca Hyeraci³, Lisa Dalla Via³, Daniele Passarella¹.

Abstract

Betulinic acid is validated as a new self-assembly inducer for the formation of nanoparticles (NPs) in combination with different drugs. The target compounds are characterized by the presence of anticancer drugs acting on tubulin dynamics and of a linker that could be a carbon chain or a triazole-based one. Nanoparticles formed are characterized and their biological activity is evaluated.

Entities: Chemical

Year: 2020 PMID： 32435402 PMCID： PMC7236225 DOI： 10.1021/acsmedchemlett.9b00668

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

11 in total

1. Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks.

Authors: Gaia Fumagalli; Michael S Christodoulou; Benedetta Riva; Inigo Revuelta; Cristina Marucci; Veronica Collico; Davide Prosperi; Sergio Riva; Dario Perdicchia; Ivan Bassanini; Aida García-Argáez; Lisa Dalla Via; Daniele Passarella
Journal: Org Biomol Chem Date: 2017-02-01 Impact factor: 3.876

Review 2. Self-assembly drug conjugates for anticancer treatment.

Authors: Gaia Fumagalli; Cristina Marucci; Michael S Christodoulou; Barbara Stella; Franco Dosio; Daniele Passarella
Journal: Drug Discov Today Date: 2016-06-18 Impact factor: 7.851

3. Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates.

Authors: Gaia Fumagalli; Barbara Stella; Ievgenia Pastushenko; Francesca Ricci; Michael S Christodoulou; Giovanna Damia; Davide Mazza; Silvia Arpicco; Clelia Giannini; Lavinia Morosi; Franco Dosio; Panagiota A Sotiropoulou; Daniele Passarella
Journal: ACS Med Chem Lett Date: 2017-08-01 Impact factor: 4.345

4. Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells.

Authors: Valentina Zuco; Rosanna Supino; Sabina C Righetti; Loredana Cleris; Edoardo Marchesi; Carlo Gambacorti-Passerini; Franca Formelli
Journal: Cancer Lett Date: 2002-01-10 Impact factor: 8.679

Review 5. Therapeutic applications of betulinic acid nanoformulations.

Authors: Ankit Saneja; Divya Arora; Robin Kumar; Ravindra Dhar Dubey; Amulya K Panda; Prem N Gupta
Journal: Ann N Y Acad Sci Date: 2018-01-29 Impact factor: 5.691

6. New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.

Authors: Stella Borrelli; Michael S Christodoulou; Ilaria Ficarra; Alessandra Silvani; Graziella Cappelletti; Daniele Cartelli; Giovanna Damia; Francesca Ricci; Massimo Zucchetti; Franco Dosio; Daniele Passarella
Journal: Eur J Med Chem Date: 2014-07-27 Impact factor: 6.514

7. Cyclopamine-Paclitaxel-Containing Nanoparticles: Internalization in Cells Detected by Confocal and Super-Resolution Microscopy.

Authors: Gaia Fumagalli; Davide Mazza; Michael S Christodoulou; Giovanna Damia; Francesca Ricci; Dario Perdicchia; Barbara Stella; Franco Dosio; Panagiota A Sotiropoulou; Daniele Passarella
Journal: Chempluschem Date: 2015-06-10 Impact factor: 2.863

New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine.

1. Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks.

Review 2. Self-assembly drug conjugates for anticancer treatment.

3. Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates.

4. Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells.

Review 5. Therapeutic applications of betulinic acid nanoformulations.

6. New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.

7. Cyclopamine-Paclitaxel-Containing Nanoparticles: Internalization in Cells Detected by Confocal and Super-Resolution Microscopy.

Review 8. The 1,2,3-triazole ring as a bioisostere in medicinal chemistry.

9. A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.

10. Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers.

1. Bioactive small-molecule constituents of Lao plants.