Literature DB >> 29795761

Heteronanoparticles by Self-Assembly of Ecdysteroid and Doxorubicin Conjugates To Overcome Cancer Resistance.

Gaia Fumagalli1, Giulia Giorgi1, Máté Vágvölgyi2, Eleonora Colombo1, Michael S Christodoulou3, Veronica Collico4, Davide Prosperi4, Franco Dosio5, Attila Hunyadi2, Monica Montopoli6, Mariafrancesca Hyeraci6, Alessandra Silvani1, Giordano Lesma1, Lisa Dalla Via6, Daniele Passarella1.   

Abstract

Heteronanoparticles (H-NPs) consisting of conjugates characterized by a squalene tail linked to doxorubicin and ecdysteroid derivatives are presented. Biological evaluation on A2780ADR cell line confirms not only the maintenance of the activity of the parental drug but also the ability to overcome cancer resistance. The in vitro cell uptake was demonstrated, and the involvement of an endosomal-mediated pathway was suggested.

Entities:  

Year:  2018        PMID： 29795761      PMCID： PMC5949839          DOI： 10.1021/acsmedchemlett.8b00078

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  13 in total

1.  Multifunctional Nanoparticles Self-Assembled from Small Organic Building Blocks for Biomedicine.

Authors:  Pengyao Xing; Yanli Zhao
Journal:  Adv Mater       Date:  2016-06-06       Impact factor: 30.849

2.  Pair correlation microscopy reveals the role of nanoparticle shape in intracellular transport and site of drug release.

Authors:  Elizabeth Hinde; Kitiphume Thammasiraphop; Hien T T Duong; Jonathan Yeow; Bunyamin Karagoz; Cyrille Boyer; J Justin Gooding; Katharina Gaus
Journal:  Nat Nanotechnol       Date:  2016-09-12       Impact factor: 39.213

Review 3.  Self-assembly drug conjugates for anticancer treatment.

Authors:  Gaia Fumagalli; Cristina Marucci; Michael S Christodoulou; Barbara Stella; Franco Dosio; Daniele Passarella
Journal:  Drug Discov Today       Date:  2016-06-18       Impact factor: 7.851

4.  Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates.

Authors:  Gaia Fumagalli; Barbara Stella; Ievgenia Pastushenko; Francesca Ricci; Michael S Christodoulou; Giovanna Damia; Davide Mazza; Silvia Arpicco; Clelia Giannini; Lavinia Morosi; Franco Dosio; Panagiota A Sotiropoulou; Daniele Passarella
Journal:  ACS Med Chem Lett       Date:  2017-08-01       Impact factor: 4.345

5.  Transport of anthracyclines and mitoxantrone across membranes by a flip-flop mechanism.

Authors:  Ronit Regev; Daniella Yeheskely-Hayon; Hagar Katzir; Gera D Eytan
Journal:  Biochem Pharmacol       Date:  2005-07-01       Impact factor: 5.858

6.  New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.

Authors:  Stella Borrelli; Michael S Christodoulou; Ilaria Ficarra; Alessandra Silvani; Graziella Cappelletti; Daniele Cartelli; Giovanna Damia; Francesca Ricci; Massimo Zucchetti; Franco Dosio; Daniele Passarella
Journal:  Eur J Med Chem       Date:  2014-07-27       Impact factor: 6.514

7.  Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter.

Authors:  Ana Martins; Noémi Tóth; Attila Ványolós; Zoltán Béni; István Zupkó; József Molnár; Mária Báthori; Attila Hunyadi
Journal:  J Med Chem       Date:  2012-05-30       Impact factor: 7.446

8.  Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics.

Authors:  José L Arias; L Harivardhan Reddy; Mohammad Othman; Brigitte Gillet; Didier Desmaële; Fatima Zouhiri; Franco Dosio; Ruxandra Gref; Patrick Couvreur
Journal:  ACS Nano       Date:  2011-01-28       Impact factor: 15.881

9.  A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity.

Authors:  Andrei Maksimenko; Franco Dosio; Julie Mougin; Annalisa Ferrero; Severine Wack; L Harivardhan Reddy; Andrée-Anne Weyn; Elise Lepeltier; Claudie Bourgaux; Barbara Stella; Luigi Cattel; Patrick Couvreur
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-02       Impact factor: 11.205

10.  Interaction of tamoxifen with the multidrug resistance P-glycoprotein.

Authors:  R Callaghan; C F Higgins
Journal:  Br J Cancer       Date:  1995-02       Impact factor: 7.640
View more
  5 in total

1.  New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine.

Authors:  Eleonora Colombo; Laura Polito; Michele Biocotino; Paola Marzullo; Mariafrancesca Hyeraci; Lisa Dalla Via; Daniele Passarella
Journal:  ACS Med Chem Lett       Date:  2020-02-28       Impact factor: 4.345

2.  Self-assembling Releasable Thiocolchicine-Diphenylbutenylaniline Conjugates.

Authors:  Gaia Fumagalli; Laura Polito; Eleonora Colombo; Francesca Foschi; Michael S Christodoulou; Francesco Galeotti; Dario Perdicchia; Ivan Bassanini; Sergio Riva; Pierfausto Seneci; Aída García-Argáez; Lisa Dalla Via; Daniele Passarella
Journal:  ACS Med Chem Lett       Date:  2019-01-04       Impact factor: 4.345

3.  Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers.

Authors:  Eleonora Colombo; Michele Biocotino; Giulia Frapporti; Pietro Randazzo; Michael S Christodoulou; Giovanni Piccoli; Laura Polito; Pierfausto Seneci; Daniele Passarella
Journal:  Pharmaceutics       Date:  2019-08-20       Impact factor: 6.321

4.  Ecdysteroid Derivatives that Reverse P-Glycoprotein-Mediated Drug Resistance.

Authors:  Roberta Bortolozzi; Andrea Luraghi; Elena Mattiuzzo; Alessandro Sacchetti; Alessandra Silvani; Giampietro Viola
Journal:  J Nat Prod       Date:  2020-08-13       Impact factor: 4.050

5.  BK002 Induces miR-192-5p-Mediated Apoptosis in Castration-Resistant Prostate Cancer Cells via Modulation of PI3K/CHOP.

Authors:  Moon Nyeo Park; Hyunmin Park; Md Ataur Rahman; Jeong Woo Kim; Se Sun Park; Yongmin Cho; Jinwon Choi; So-Ri Son; Dae Sik Jang; Bum-Sang Shim; Sung-Hoon Kim; Seong-Gyu Ko; Chunhoo Cheon; Bonglee Kim
Journal:  Front Oncol       Date:  2022-03-07       Impact factor: 6.244
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.