Literature DB >> 28938120

Prion-like Domains Program Ewing's Sarcoma.

James Shorter1.   

Abstract

Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcriptional programs underlying Ewing's sarcoma.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28938120      PMCID： PMC5639709          DOI： 10.1016/j.cell.2017.09.010

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

Review 1.  The TET family of proteins: functions and roles in disease.

Authors:  Adelene Y Tan; James L Manley
Journal:  J Mol Cell Biol       Date:  2009-09-24       Impact factor: 6.216

2.  EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.

Authors:  Nicolò Riggi; Birgit Knoechel; Shawn M Gillespie; Bradley E Bernstein; Miguel N Rivera; Esther Rheinbay; Gaylor Boulay; Mario L Suvà; Nikki E Rossetti; Wannaporn E Boonseng; Ozgur Oksuz; Edward B Cook; Aurélie Formey; Anoop Patel; Melissa Gymrek; Vishal Thapar; Vikram Deshpande; David T Ting; Francis J Hornicek; G Petur Nielsen; Ivan Stamenkovic; Martin J Aryee
Journal:  Cancer Cell       Date:  2014-10-30       Impact factor: 31.743

3.  Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain.

Authors:  Gaylor Boulay; Gabriel J Sandoval; Nicolo Riggi; Sowmya Iyer; Rémi Buisson; Beverly Naigles; Mary E Awad; Shruthi Rengarajan; Angela Volorio; Matthew J McBride; Liliane C Broye; Lee Zou; Ivan Stamenkovic; Cigall Kadoch; Miguel N Rivera
Journal:  Cell       Date:  2017-08-24       Impact factor: 41.582

4.  Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

Authors:  Julien Couthouis; Michael P Hart; Renske Erion; Oliver D King; Zamia Diaz; Tadashi Nakaya; Fadia Ibrahim; Hyung-Jun Kim; Jelena Mojsilovic-Petrovic; Saarene Panossian; Cecilia E Kim; Edward C Frackelton; Jennifer A Solski; Kelly L Williams; Dana Clay-Falcone; Lauren Elman; Leo McCluskey; Robert Greene; Hakon Hakonarson; Robert G Kalb; Virginia M Y Lee; John Q Trojanowski; Garth A Nicholson; Ian P Blair; Nancy M Bonini; Vivianna M Van Deerlin; Zissimos Mourelatos; James Shorter; Aaron D Gitler
Journal:  Hum Mol Genet       Date:  2012-03-27       Impact factor: 6.150

5.  Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains.

Authors:  Ilmin Kwon; Masato Kato; Siheng Xiang; Leeju Wu; Pano Theodoropoulos; Hamid Mirzaei; Tina Han; Shanhai Xie; Jeffry L Corden; Steven L McKnight
Journal:  Cell       Date:  2013-11-21       Impact factor: 41.582

6.  Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.

Authors:  Masato Kato; Tina W Han; Shanhai Xie; Kevin Shi; Xinlin Du; Leeju C Wu; Hamid Mirzaei; Elizabeth J Goldsmith; Jamie Longgood; Jimin Pei; Nick V Grishin; Douglas E Frantz; Jay W Schneider; She Chen; Lin Li; Michael R Sawaya; David Eisenberg; Robert Tycko; Steven L McKnight
Journal:  Cell       Date:  2012-05-11       Impact factor: 41.582

7.  Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.

Authors:  Zachary Monahan; Veronica H Ryan; Abigail M Janke; Kathleen A Burke; Shannon N Rhoads; Gül H Zerze; Robert O'Meally; Gregory L Dignon; Alexander E Conicella; Wenwei Zheng; Robert B Best; Robert N Cole; Jeetain Mittal; Frank Shewmaker; Nicolas L Fawzi
Journal:  EMBO J       Date:  2017-08-08       Impact factor: 11.598

8.  Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.

Authors:  Yuan Lin; David S W Protter; Michael K Rosen; Roy Parker
Journal:  Mol Cell       Date:  2015-09-24       Impact factor: 17.970

Review 9.  Assemblages: functional units formed by cellular phase separation.

Authors:  Jeffrey A Toretsky; Peter E Wright
Journal:  J Cell Biol       Date:  2014-09-01       Impact factor: 10.539

Review 10.  Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease.

Authors:  Zachary M March; Oliver D King; James Shorter
Journal:  Brain Res       Date:  2016-03-18       Impact factor: 3.252
  10 in total
  7 in total

1.  Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma.

Authors:  Jeremy J Ryan; Macy L Sprunger; Kayla Holthaus; James Shorter; Meredith E Jackrel
Journal:  J Biol Chem       Date:  2019-06-05       Impact factor: 5.157

Review 2.  The molecular language of membraneless organelles.

Authors:  Edward Gomes; James Shorter
Journal:  J Biol Chem       Date:  2018-07-25       Impact factor: 5.157

3.  Microfluidic characterization of macromolecular liquid-liquid phase separation.

Authors:  Anne Bremer; Tanja Mittag; Michael Heymann
Journal:  Lab Chip       Date:  2020-11-10       Impact factor: 6.799

4.  Modulating gene regulation function by chemically controlled transcription factor clustering.

Authors:  Jiegen Wu; Baoqiang Chen; Yadi Liu; Liang Ma; Wen Huang; Yihan Lin
Journal:  Nat Commun       Date:  2022-05-13       Impact factor: 17.694

5.  FUS oncofusion protein condensates recruit mSWI/SNF chromatin remodeler via heterotypic interactions between prion-like domains.

Authors:  Richoo B Davis; Taranpreet Kaur; Mahdi Muhammad Moosa; Priya R Banerjee
Journal:  Protein Sci       Date:  2021-06-04       Impact factor: 6.993

Review 6.  Biochemical Timekeeping Via Reentrant Phase Transitions.

Authors:  Bede Portz; James Shorter
Journal:  J Mol Biol       Date:  2020-12-31       Impact factor: 6.151

7.  FGviewer: an online visualization tool for functional features of human fusion genes.

Authors:  Pora Kim; Ke Yiya; Xiaobo Zhou
Journal:  Nucleic Acids Res       Date:  2020-07-02       Impact factor: 16.971
  7 in total

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