| Literature DB >> 3713863 |
J Flint, A V Hill, D K Bowden, S J Oppenheimer, P R Sill, S W Serjeantson, J Bana-Koiri, K Bhatia, M P Alpers, A J Boyce.
Abstract
The frequency of alpha+-thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high frequencies of haemoglobinopathies in many parts of the world.Entities:
Mesh：
Year: 1986 PMID： 3713863 DOI： 10.1038/321744a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962