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Literature DB >> 2890297

Linkage of DNA probe B79a (D7S13) to cystic fibrosis.

B J Wainwright¹, L C Tsui, M Leppert, M Buchwald, X Estivill, P O'Connell, M Lathrop, J M Lalouel, R White, R Williamson.

Abstract

We have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at theta = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.

Entities: Disease

Mesh：

Substances：
Genetic Markers
DNA

Year: 1987 PMID： 2890297 PMCID： PMC1684343

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

13 in total

1. Linkage disequilibrium among multiple neutral alleles produced by mutation in finite population.

Authors: W G Hill
Journal: Theor Popul Biol Date: 1975-10 Impact factor: 1.570

2. Regional mapping of six cloned DNA sequences on human chromosome 7.

Authors: I Bartels; K H Grzeschik; D N Cooper; J Schmidtke
Journal: Am J Hum Genet Date: 1986-03 Impact factor: 11.025

3. Localisation of a sequence, 7C22, showing close linkage to the cystic fibrosis locus.

Authors: V J Buckle; P J Scambler; B J Wainwright
Journal: Cytogenet Cell Genet Date: 1987

4. Isolation of a further anonymous informative DNA sequence from chromosome seven closely linked to cystic fibrosis.

Authors: P J Scambler; B J Wainwright; E Watson; G Bates; G Bell; R Williamson; M Farrall
Journal: Nucleic Acids Res Date: 1986-03-11 Impact factor: 16.971

5. Linkage of COL1A2 collagen gene to cystic fibrosis, and its clinical implications.

Authors: P J Scambler; B J Wainwright; M Farrall; J Bell; P Stanier; N J Lench; G Bell; H Kruyer; F Ramirez; R Williamson
Journal: Lancet Date: 1985-11-30 Impact factor: 79.321

6. The human met oncogene is related to the tyrosine kinase oncogenes.

Authors: M Dean; M Park; M M Le Beau; T S Robins; M O Diaz; J D Rowley; D G Blair; G F Vande Woude
Journal: Nature Date: 1985 Nov 28-Dec 4 Impact factor: 49.962

7. A closely linked genetic marker for cystic fibrosis.

Authors: R White; S Woodward; M Leppert; P O'Connell; M Hoff; J Herbst; J M Lalouel; M Dean; G Vande Woude
Journal: Nature Date: 1985 Nov 28-Dec 4 Impact factor: 49.962

8. Strategies for multilocus linkage analysis in humans.

Authors: G M Lathrop; J M Lalouel; C Julier; J Ott
Journal: Proc Natl Acad Sci U S A Date: 1984-06 Impact factor: 11.205

Review 9. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

Authors: D Botstein; R L White; M Skolnick; R W Davis
Journal: Am J Hum Genet Date: 1980-05 Impact factor: 11.025

10. Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker.

Authors: L C Tsui; M Buchwald; D Barker; J C Braman; R Knowlton; J W Schumm; H Eiberg; J Mohr; D Kennedy; N Plavsic
Journal: Science Date: 1985-11-29 Impact factor: 47.728

5 in total

1. Identification and regional localization of DNA markers on chromosome 7 for the cloning of the cystic fibrosis gene.

Authors: J M Rommens; S Zengerling; J Burns; G Melmer; B S Kerem; N Plavsic; M Zsiga; D Kennedy; D Markiewicz; R Rozmahel
Journal: Am J Hum Genet Date: 1988-11 Impact factor: 11.025

2. Localization of DNA probes with tight linkage to the cystic fibrosis locus by in situ hybridization using fibroblasts with a 7q22 deletion.

Authors: A H van der Hout; A Y van der Veen; J A Aten; C H Buys
Journal: Hum Genet Date: 1988-10 Impact factor: 4.132