Greg Stortz1, Jonathan D Thiessen2,3, Daryl Bishop4, Muhammad Salman Khan5, Piotr Kozlowski6, Fabrice Retière4, Graham Schellenberg7, Ehsan Shams8, Xuezhu Zhang9,10, Christopher J Thompson11, Andrew L Goertzen9,7, Vesna Sossi12. 1. Department of Physics and Astronomy at the University of British Columbia, Vancouver, British Columbia, Canada greg.stortz@alumni.ubc.ca. 2. Department of Medical Biophysics, Western University, London, Ontario, Canada. 3. Graduate Program in Biomedical Engineering, University of Manitoba, Winnipeg, Manitoba, Canada. 4. Detector Development Group, TRIUMF, Vancouver, British Columbia, Canada. 5. Department of Electrical Computer Engineering, University of Manitoba, Winnipeg, Manitoba, Canada. 6. Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada. 7. Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada. 8. Biomedical Engineering Graduate Program, University of Manitoba, Winnipeg, Manitoba, Canada. 9. Department of Radiology, University of Manitoba, Winnipeg, Manitoba, Canada. 10. Department of Biomedical Engineering, University of California, Davis, Davis, California; and. 11. Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. 12. Department of Physics and Astronomy at the University of British Columbia, Vancouver, British Columbia, Canada.
Abstract
We characterize a compact MR-compatible PET insert for simultaneous preclinical PET/MRI. Although specifically designed with the strict size constraint to fit inside the 114-mm inner diameter of the BGA-12S gradient coil used in the BioSpec 70/20 and 94/20 series of small-animal MRI systems, the insert can easily be installed in any appropriate MRI scanner or used as a stand-alone PET system. Methods: The insert consists of a ring of 16 detector-blocks each made from depth-of-interaction-capable dual-layer-offset arrays of cerium-doped lutetium-yttrium oxyorthosilicate crystals read out by silicon photomultiplier arrays. Scintillator crystal arrays are made from 22 × 10 and 21 × 9 crystals in the bottom and top layers, respectively, with respective layer thicknesses of 6 and 4 mm, arranged with a 1.27-mm pitch, resulting in a useable field of view 28 mm long and about 55 mm wide. Results: Spatial resolution ranged from 1.17 to 1.86 mm full width at half maximum in the radial direction from a radial offset of 0-15 mm. With a 300- to 800-keV energy window, peak sensitivity was 2.2% and noise-equivalent count rate from a mouse-sized phantom at 3.7 MBq was 11.1 kcps and peaked at 20.8 kcps at 14.5 MBq. Phantom imaging showed that features as small as 0.7 mm could be resolved. 18F-FDG PET/MR images of mouse and rat brains showed no signs of intermodality interference and could excellently resolve substructures within the brain. Conclusion: Because of excellent spatial resolvability and lack of intermodality interference, this PET insert will serve as a useful tool for preclinical PET/MR.
We characterize a compact MR-compatible PET insert for simultaneous preclinical PET/MRI. Although specifically designed with the strict size constraint to fit inside the 114-mm inner diameter of the BGA-12S gradient coil used in the BioSpec 70/20 and 94/20 series of small-animal MRI systems, the insert can easily be installed in any appropriate MRI scanner or used as a stand-alone PET system. Methods: The insert consists of a ring of 16 detector-blocks each made from depth-of-interaction-capable dual-layer-offset arrays of cerium-doped lutetium-yttrium oxyorthosilicate crystals read out by silicon photomultiplier arrays. Scintillator crystal arrays are made from 22 × 10 and 21 × 9 crystals in the bottom and top layers, respectively, with respective layer thicknesses of 6 and 4 mm, arranged with a 1.27-mm pitch, resulting in a useable field of view 28 mm long and about 55 mm wide. Results: Spatial resolution ranged from 1.17 to 1.86 mm full width at half maximum in the radial direction from a radial offset of 0-15 mm. With a 300- to 800-keV energy window, peak sensitivity was 2.2% and noise-equivalent count rate from a mouse-sized phantom at 3.7 MBq was 11.1 kcps and peaked at 20.8 kcps at 14.5 MBq. Phantom imaging showed that features as small as 0.7 mm could be resolved. 18F-FDG PET/MR images of mouse and rat brains showed no signs of intermodality interference and could excellently resolve substructures within the brain. Conclusion: Because of excellent spatial resolvability and lack of intermodality interference, this PET insert will serve as a useful tool for preclinical PET/MR.
Authors: Raymond R Raylman; Patrick Ledden; Alexander V Stolin; Bob Hou; Ganghadar Jaliparthi; Peter F Martone Journal: J Med Imaging (Bellingham) Date: 2018-09-08
Authors: Émilie Gaudin; Christian Thibaudeau; Louis Arpin; Jean-Daniel Leroux; Maxime Toussaint; Jean-Francois Beaudoin; Jules Cadorette; Maxime Paillé; Catherine M Pepin; Konin Koua; Jonathan Bouchard; Nicolas Viscogliosi; Caroline Paulin; Réjean Fontaine; Roger Lecomte Journal: Phys Med Biol Date: 2021-03-09 Impact factor: 3.609