| Literature DB >> 28892062 |
Masato Akiyama1, Yukinori Okada1,2,3, Masahiro Kanai1, Atsushi Takahashi1,4, Yukihide Momozawa5, Masashi Ikeda6, Nakao Iwata6, Shiro Ikegawa7, Makoto Hirata8, Koichi Matsuda9, Motoki Iwasaki10, Taiki Yamaji10, Norie Sawada10, Tsuyoshi Hachiya11, Kozo Tanno11,12, Atsushi Shimizu11, Atsushi Hozawa13,14, Naoko Minegishi13,14, Shoichiro Tsugane15, Masayuki Yamamoto13,14, Michiaki Kubo16, Yoichiro Kamatani1,17.
Abstract
Obesity is a risk factor for a wide variety of health problems. In a genome-wide association study (GWAS) of body mass index (BMI) in Japanese people (n = 173,430), we found 85 loci significantly associated with obesity (P < 5.0 × 10-8), of which 51 were previously unknown. We conducted trans-ancestral meta-analyses by integrating these results with the results from a GWAS of Europeans and identified 61 additional new loci. In total, this study identifies 112 novel loci, doubling the number of previously known BMI-associated loci. By annotating associated variants with cell-type-specific regulatory marks, we found enrichment of variants in CD19+ cells. We also found significant genetic correlations between BMI and lymphocyte count (P = 6.46 × 10-5, rg = 0.18) and between BMI and multiple complex diseases. These findings provide genetic evidence that lymphocytes are relevant to body weight regulation and offer insights into the pathogenesis of obesity.Entities:
Mesh：
Year: 2017 PMID： 28892062 DOI： 10.1038/ng.3951
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330