| Literature DB >> 24861553 |
Wanqing Wen1, Wei Zheng1, Yukinori Okada2, Fumihiko Takeuchi3, Yasuharu Tabara4, Joo-Yeon Hwang5, Rajkumar Dorajoo6, Huaixing Li7, Fuu-Jen Tsai8, Xiaobo Yang9, Jiang He10, Ying Wu11, Meian He12, Yi Zhang13, Jun Liang14, Xiuqing Guo15, Wayne Huey-Herng Sheu16, Ryan Delahanty1, Xingyi Guo1, Michiaki Kubo17, Ken Yamamoto18, Takayoshi Ohkubo19, Min Jin Go5, Jian Jun Liu20, Wei Gan7, Ching-Chu Chen21, Yong Gao22, Shengxu Li10, Nanette R Lee23, Chen Wu24, Xueya Zhou25, Huaidong Song26, Jie Yao15, I-Te Lee27, Jirong Long1, Tatsuhiko Tsunoda28, Koichi Akiyama3, Naoyuki Takashima29, Yoon Shin Cho30, Rick Th Ong31, Ling Lu7, Chien-Hsiun Chen32, Aihua Tan33, Treva K Rice34, Linda S Adair35, Lixuan Gui12, Matthew Allison36, Wen-Jane Lee37, Qiuyin Cai1, Minoru Isomura38, Satoshi Umemura39, Young Jin Kim5, Mark Seielstad40, James Hixson41, Yong-Bing Xiang42, Masato Isono3, Bong-Jo Kim5, Xueling Sim43, Wei Lu44, Toru Nabika38, Juyoung Lee5, Wei-Yen Lim45, Yu-Tang Gao46, Ryoichi Takayanagi47, Dae-Hee Kang48, Tien Yin Wong49, Chao Agnes Hsiung50, I-Chien Wu50, Jyh-Ming Jimmy Juang51, Jiajun Shi1, Bo Youl Choi52, Tin Aung49, Frank Hu53, Mi Kyung Kim52, Wei Yen Lim45, Tzung-Dao Wang51, Min-Ho Shin54, Jeannette Lee45, Bu-Tian Ji55, Young-Hoon Lee56, Terri L Young57, Dong Hoon Shin58, Byung-Yeol Chun59, Myeong-Chan Cho60, Bok-Ghee Han5, Chii-Min Hwu61, Themistocles L Assimes62, Devin Absher63, Xiaofei Yan15, Eric Kim15, Jane Z Kuo64, Soonil Kwon15, Kent D Taylor15, Yii-Der I Chen15, Jerome I Rotter15, Lu Qi65, Dingliang Zhu13, Tangchun Wu12, Karen L Mohlke11, Dongfeng Gu66, Zengnan Mo67, Jer-Yuarn Wu32, Xu Lin7, Tetsuro Miki68, E Shyong Tai69, Jong-Young Lee5, Norihiro Kato3, Xiao-Ou Shu70, Toshihiro Tanaka71.
Abstract
Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.Entities:
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Year: 2014 PMID： 24861553 PMCID： PMC4168820 DOI： 10.1093/hmg/ddu248
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150