| Literature DB >> 28877457 |
Megan N Roberts1, Marita A Wallace2, Alexey A Tomilov1, Zeyu Zhou1, George R Marcotte2, Dianna Tran1, Gabriella Perez1, Elena Gutierrez-Casado3, Shinichiro Koike4, Trina A Knotts1, Denise M Imai5, Stephen M Griffey5, Kyoungmi Kim6, Kevork Hagopian1, Marissa Z McMackin1, Fawaz G Haj4, Keith Baar7, Gino A Cortopassi1, Jon J Ramsey8, Jose Alberto Lopez-Dominguez9.
Abstract
Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physiological function after 1 or 14 months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.Entities:
Keywords: aging; beta-hydroxybutyrate; healthspan; ketogenic diet; ketone bodies; ketones; lifespan; longevity; low-carbohydrate diet; memory
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Year: 2017 PMID： 28877457 PMCID： PMC5609489 DOI： 10.1016/j.cmet.2017.08.005
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287