| Literature DB >> 26094889 |
Sebastian Brandhorst1, In Young Choi1, Min Wei1, Chia Wei Cheng1, Sargis Sedrakyan2, Gerardo Navarrete1, Louis Dubeau3, Li Peng Yap4, Ryan Park4, Manlio Vinciguerra5, Stefano Di Biase1, Hamed Mirzaei1, Mario G Mirisola6, Patra Childress7, Lingyun Ji8, Susan Groshen8, Fabio Penna9, Patrizio Odetti10, Laura Perin2, Peter S Conti4, Yuji Ikeno11, Brian K Kennedy12, Pinchas Cohen1, Todd E Morgan1, Tanya B Dorff13, Valter D Longo14.
Abstract
Prolonged fasting (PF) promotes stress resistance, but its effects on longevity are poorly understood. We show that alternating PF and nutrient-rich medium extended yeast lifespan independently of established pro-longevity genes. In mice, 4 days of a diet that mimics fasting (FMD), developed to minimize the burden of PF, decreased the size of multiple organs/systems, an effect followed upon re-feeding by an elevated number of progenitor and stem cells and regeneration. Bi-monthly FMD cycles started at middle age extended longevity, lowered visceral fat, reduced cancer incidence and skin lesions, rejuvenated the immune system, and retarded bone mineral density loss. In old mice, FMD cycles promoted hippocampal neurogenesis, lowered IGF-1 levels and PKA activity, elevated NeuroD1, and improved cognitive performance. In a pilot clinical trial, three FMD cycles decreased risk factors/biomarkers for aging, diabetes, cardiovascular disease, and cancer without major adverse effects, providing support for the use of FMDs to promote healthspan.Entities:
Mesh：
Year: 2015 PMID： 26094889 PMCID： PMC4509734 DOI： 10.1016/j.cmet.2015.05.012
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287