Mohamed Mutalib1, David Rawat2, Keith Lindley3, Osvaldo Borrelli3, Steve Perring4, Marcus K H Auth5, Nikhil Thapar3. 1. Paediatric Gastroenterology Department, Evelina London Children's Hospital, London, UK. 2. Paediatric Gastroenterology Department, Royal London Hospital, London, UK. 3. Paediatric Gastroenterology Department, Great Ormond Street Hospital, London, UK. 4. Department of Medical Physics, Poole Hospital, Poole, UK. 5. Department of Paediatric Gastroenterology, Hepatology and Nutrition, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Abstract
BACKGROUND: Combined pH-impedance monitoring has been suggested as the investigation of choice for diagnosing gastro-oesophageal reflux in children. Although it is superior to oesophageal pH monitoring in detecting all types of reflux episodes (acid, weakly acidic and alkaline) with the ability to evaluate symptom association with reflux events, it is still limited by the lack of true paediatric normal value and the high cost involved (equipment and personnel). OBJECTIVE: To produce a position statement on behalf of the Motility Working Group of the British Society of Paediatric Gastroenterology, Hepatology and Nutrition on the indications and practical application of combined oesophageal pH-impedance monitoring in children. METHODS: Up-to-date review of available evidence. RESULTS: This document provides a practical guide to clinician on indications, methods and results interpretation of paediatric multichannel intraluminal impedance pH (MII-pH). CONCLUSIONS: MII-pH is increasingly used by paediatricians as the diagnostic tool for assessing gastro-oesophageal reflux disease and symptom association. There is wide variation in paediatric practice and a need for standardised practice.
BACKGROUND: Combined pH-impedance monitoring has been suggested as the investigation of choice for diagnosing gastro-oesophageal reflux in children. Although it is superior to oesophageal pH monitoring in detecting all types of reflux episodes (acid, weakly acidic and alkaline) with the ability to evaluate symptom association with reflux events, it is still limited by the lack of true paediatric normal value and the high cost involved (equipment and personnel). OBJECTIVE: To produce a position statement on behalf of the Motility Working Group of the British Society of Paediatric Gastroenterology, Hepatology and Nutrition on the indications and practical application of combined oesophageal pH-impedance monitoring in children. METHODS: Up-to-date review of available evidence. RESULTS: This document provides a practical guide to clinician on indications, methods and results interpretation of paediatric multichannel intraluminal impedance pH (MII-pH). CONCLUSIONS: MII-pH is increasingly used by paediatricians as the diagnostic tool for assessing gastro-oesophageal reflux disease and symptom association. There is wide variation in paediatric practice and a need for standardised practice.
Authors: Hayat Mousa; Rodrigo Machado; Marina Orsi; Catherine S Chao; Tala Alhajj; Mark Alhajj; Courtney Port; Beth Skaggs; Frederick W Woodley Journal: Curr Gastroenterol Rep Date: 2014-08
Authors: O Borrelli; S Salvatore; V Mancini; M Ribolsi; M Gentile; B Bizzarri; M Cicala; K J Lindley; G L De'angelis Journal: Neurogastroenterol Motil Date: 2012-06-11 Impact factor: 3.598